Nikola Kozhuharov
A5034750511- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Acute Myocardial Infarction Research
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Emergency and Acute Care Studies
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Structural Anomalies and Repair
- Coronary Interventions and Diagnostics
- Sepsis Diagnosis and Treatment
- Blood Pressure and Hypertension Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac Health and Mental Health
- Cardiovascular and exercise physiology
- Cardiovascular Issues in Pregnancy
- ECG Monitoring and Analysis
- Heart Rate Variability and Autonomic Control
- Electrolyte and hormonal disorders
- Chronic Disease Management Strategies
- Cardiac, Anesthesia and Surgical Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Effects of Exercise
University of Bern
2022-2025
University Hospital of Bern
2022-2025
Liverpool Heart and Chest Hospital
2020-2024
University of Liverpool
2020-2024
University of Basel
2017-2024
University Hospital of Basel
2016-2024
Cardiovascular Institute Hospital
2019-2024
University Hospital of Geneva
2022-2023
University of Freiburg
2018
Martin Luther University Halle-Wittenberg
2017
Perioperative myocardial injury (PMI) seems to be a contributor mortality after noncardiac surgery. Because the vast majority of PMIs are asymptomatic, PMI usually is missed in absence systematic screening. We performed prospective diagnostic study enrolling consecutive patients undergoing surgery who had planned postoperative stay ≥24 hours and were considered at increased cardiovascular risk. All received screening using serial measurements high-sensitivity cardiac troponin T clinical...
Background: Four strategies for very early rule-out of acute myocardial infarction using high-sensitivity cardiac troponin I (hs-cTnI) have been identified. It remains unclear which strategy is most attractive clinical application. Methods: We prospectively enrolled unselected patients presenting to the emergency department with symptoms suggestive infarction. The final diagnosis was adjudicated by 2 independent cardiologists. Hs-cTnI levels were measured at presentation and after 1 hour in...
The European Society of Cardiology recommends a 0/1-hour algorithm for rapid rule-out and rule-in non-ST-segment elevation myocardial infarction using high-sensitivity cardiac troponin (hs-cTn) concentrations irrespective renal function. Because patients with dysfunction (RD) frequently present increased hs-cTn even in the absence infarction, concern has been raised regarding performance RD. In prospective multicenter diagnostic study enrolling unselected presenting suspected to emergency...
Abstract BACKGROUND Clinical performance of the novel high-sensitivity cardiac troponin I (Siemens-hs-cTnI-Centaur) assay is unknown. We aimed to clinically validate Siemens-hs-cTnI-Centaur and develop 0/1-h 0/2-h algorithms. METHODS enrolled patients presenting emergency department with symptoms suggestive acute myocardial infarction (AMI). Final diagnoses were centrally adjudicated by 2 independent cardiologists including all clinical information twice: first, using serial hs-cTnT...
Until now, high-sensitivity cardiac troponin (hs-cTn) assays were mainly developed for large central laboratory platforms. This study aimed to assess the clinical performance of a point-of-care (POC)-hs-cTnI assay in patients with suspected myocardial infarction (MI). enrolled presenting emergency department symptoms suggestive MI. Two cardiologists centrally adjudicated final diagnosis using all data including imaging. The primary objective was directly compare diagnostic accuracy...
<h3>Importance</h3> Short-term infusions of single vasodilators, usually given in a fixed dose, have not improved outcomes patients with acute heart failure (AHF). <h3>Objective</h3> To evaluate the effect strategy that emphasized early intensive and sustained vasodilation using individualized up-titrated doses established vasodilators AHF. <h3>Design, Setting, Participants</h3> Randomized, open-label blinded-end-point trial enrolling 788 hospitalized for AHF dyspnea, increased plasma...
We aimed to evaluate the impact of age on performance European Society Cardiology (ESC) 0/1h-algorithms and derive externally validate alternative cut-offs specific older patients.We prospectively enrolled patients presenting emergency department (ED) with symptoms suggestive acute myocardial infarction in three large diagnostic studies. Final diagnoses were adjudicated by two independent cardiologists. High-sensitivity cardiac troponin (hs-cTn) T I concentrations measured at presentation...
It is currently unknown whether the uniform (universal clinical practice for more than 2 decades) or sex-specific cutoff levels are preferable when using high-sensitivity cardiac troponin T (hs-cTnT) in diagnosis of acute myocardial infarction (AMI).To improve management suspected AMI women by exploring vs hs-cTnT.In an ongoing prospective, diagnostic, multicenter study conducted at 9 emergency departments, present evaluated patients enrolled from April 21, 2006, through June 5, 2013. The...
The aim of this study was to validate the clinical performance Beckman Access high-sensitivity cardiac troponin I (hs-cTnI) assay.We enrolled patients presenting emergency department with symptoms suggestive acute myocardial infarction (AMI). Final diagnoses were centrally adjudicated by 2 independent cardiologists all information including imaging twice: first, using serial hs-cTnT (Elecsys, primary analysis), and second, hs-cTnI (Architect, secondary analysis) measurements in addition...
The left atrial posterior wall is a potential ablation target in patients with recurrent fibrillation despite durable pulmonary vein isolation or roof-dependent tachycardia (AT). Pulsed-field (PFA) offers efficient and safe (PWA), but available data are scarce.
Left bundle branch area pacing (LBBAP) is most often delivered using lumenless leads (LLLs), but may also be performed stylet-driven (SDLs). There are limited reports on the comparison of these tools, mainly to describing initial operator experience or without detailed procedural data. Our aim was perform an in-depth SDLs and LLLs for LBBAP at implantation follow-up in a larger cohort patients with that extends beyond learning curve.A total 306 consecutive (age 77 ± 11 years, 183 males)...
Pulmonary vein isolation (PVI) is increasingly performed in patients with atrial fibrillation (AF). Both AF phenotype and left (LA) volume have been shown to influence ablation outcome. The inter-relationship of the two incompletely understood. We aimed investigate impact vs. LA on outcome after PVI.
Background: Combining 2 signals of cardiomyocyte injury, cardiac troponin I (cTnI) and T (cTnT), might overcome some individual pathophysiological analytical limitations thereby increase diagnostic accuracy for acute myocardial infarction with a single blood draw. We aimed to evaluate the performance combinations high-sensitivity (hs) cTnI hs-cTnT early diagnosis infarction. Methods: The combining hs-cTnI (Architect, Abbott) (Elecsys, Roche) concentrations (sum, product, ratio, combination...
Cardiac myosin-binding protein C (cMyC) is a cardiac-restricted that more abundant than cardiac troponins (cTn) and released rapidly after acute myocardial infarction (AMI). We evaluated cMyC as an adjunct or alternative to cTn in the early diagnosis of AMI.
Objective Assess the relative incidence and compare characteristics outcome of unstable angina (UA) non-ST-elevation myocardial infarction (NSTEMI). Design Two independent prospective multicentre diagnostic studies (Advantageous Predictors Acute Coronary Syndromes Evaluation [APACE] High-Sensitivity Troponin in Patients With Syndrome [High-STEACS]) enrolling patients with acute chest discomfort presenting to emergency department. Central adjudication final diagnosis was done by two...
Abstract Background Pulsed-field ablation (PFA) has shown favourable data in terms of safety and procedural efficiency for pulmonary vein isolation (PVI). We sought to compare 1-year follow-up patients with paroxysmal atrial fibrillation (AF) undergoing PVI using PFA, cryoballoon (CBA) radiofrequency (RFA). Methods Consecutive AF a first PFA at our institution were included. For comparison, CBA RFA selected 1:2:2 propensity score matching. The group followed the standard 32-applications...