A5079365401- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Cardiomyopathy and Myosin Studies
- Viral Infections and Immunology Research
- Cardiovascular Effects of Exercise
- Heart Failure Treatment and Management
- Cardiovascular Disease and Adiposity
- Atrial Fibrillation Management and Outcomes
- Bariatric Surgery and Outcomes
- Cardiac Fibrosis and Remodeling
- Cardiac, Anesthesia and Surgical Outcomes
- Venous Thromboembolism Diagnosis and Management
- COVID-19 and healthcare impacts
- Pulmonary Hypertension Research and Treatments
- Vascular Procedures and Complications
- Takotsubo Cardiomyopathy and Associated Phenomena
- Sepsis Diagnosis and Treatment
- Peripheral Artery Disease Management
- Cardiac Health and Mental Health
- Cardiovascular Issues in Pregnancy
King's College London
2015-2024
St Thomas' Hospital
2015-2024
Guy's and St Thomas' NHS Foundation Trust
2023-2024
National Health Service
2024
British Heart Foundation
2018-2023
Heart Foundation
2018
St. Thomas Hospital
2017-2018
GTx (United States)
2018
Aarhus University Hospital
2018
Royal Free London NHS Foundation Trust
2017
Abstract BACKGROUND Myocardial infarction is diagnosed when biomarkers of cardiac necrosis exceed the 99th centile, although guidelines advocate even lower concentrations for early rule-out. We examined how many myocytes and much myocardium these represent. also if dietary troponin can confound rule-out algorithm. METHODS Individual rat myocytes, myocardium, ovine or human were spiked into 400-μL aliquots serum. Blood was drawn from a volunteer after ingestion myocardium. High-sensitivity...
Cardiac myosin-binding protein C (cMyC) is a cardiac-restricted that more abundant than cardiac troponins (cTn) and released rapidly after acute myocardial infarction (AMI). We evaluated cMyC as an adjunct or alternative to cTn in the early diagnosis of AMI.
The aim of the study was to examine ventricular remodelling in patients free cardiac risk factors, before, and 6 months post-bariatric surgery with new imaging modality three-dimensional (3D) strain comparison two surgical techniques: sleeve gastrectomy vs. gastric bypass.Fifty-two consecutive referred Bariatric Services Imperial College NHS Trust were examined conventional 2D 3D echocardiography, prior after bariatric surgery. They all from disease. cohort's mean age 44.2 ± 8.7 years body...
Rapid and accurate noninvasive discrimination of type 2 myocardial infarction (T2MI), which is because a supply-demand mismatch, from 1 (T1MI), arises via plaque rupture, essential, treatment differs substantially. Unfortunately, this major unmet clinical need, even high-sensitivity cardiac troponin (hs-cTn) measurement provides only modest accuracy.
Cardiac troponins (cTns) are released and cleared slowly after myocardial injury. myosin-binding protein C (cMyC) is a similar cardiac-restricted that has more rapid release clearance kinetics. Direct comparisons hampered by the lack of an assay for cMyC matches sensitivity contemporary assays cTnI cTnT. Using novel pair monoclonal antibodies, we generated sensitive MyC on Erenna platform (Singulex) compared serum concentrations with those (Abbott) cTnT (Roche) in stable ambulatory cardiac...
Background Early triage is essential to improve outcomes in patients with suspected acute myocardial infarction ( AMI ). This study investigated whether cMyC (cardiac myosin‐binding protein), a novel biomarker of necrosis, can aid early diagnosis and risk stratification. Methods Results high‐sensitivity cardiac troponin T were retrospectively quantified blood samples obtained by ambulance‐based paramedics prospective, diagnostic cohort study. Patients ongoing or prolonged periods chest...
Objective Takotsubo syndrome (TTS) is an acute heart failure which resembles coronary (ACS) at presentation. Differentiation requires angiography, but where this does not occur immediately, cardiac biomarkers may provide additional utility. We performed a meta-analysis to compare troponin and natriuretic peptides (NPs) in TTS ACS determine if differences biomarker profile can aid diagnosis. Methods searched five literature databases for studies reporting NPs (Brain NP (BNP)/NT-pro-BNP) or...
Objective Cardiac myosin-binding protein C (cMyC) is an abundant sarcomeric and novel highly specific marker of myocardial injury. Myocyte death characterises the transition from hypertrophy to replacement fibrosis in advanced aortic stenosis. We hypothesised that serum cMyC concentrations would be associated with cardiac structure outcomes patients Methods was measured two cohorts which had previously been prospectively collected: a mechanism cohort stenosis (n=161) healthy controls (n=46)...
To evaluate the clinical feasibility of implementing 2020 ESC 0/1 hr algorithm for rapid rule-out/rule-in acute coronary syndrome (ACS).Data were collected retrospectively from 5496 patients in and 7363 2021 who received cardiac troponin measurements through ACS care settings within a large tertiary centre United Kingdom. This period overlapped introduction algorithm. After exclusion haemolysis, 1905 underwent repeat measurement study 2658 2021. Median time to was significantly reduced 3 h...
There has been a gradual upward creep of revascularization thresholds for both fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR), before the clinical outcome trials indices. The increase in that potentially resulted is at odds with increasing evidence questioning benefits revascularizing stable coronary disease. Using an independent invasive reference standard, this study primarily aimed to define optimal FFR iFR also compare performance iFR, FFR, resting distal pressure...
A 77-year-old man presented with exertional chest pain
Aims: In 2015, the European Society of Cardiology introduced new guidelines for diagnosis acute coronary syndromes in patients presenting without persistent ST-segment elevation. These included use high-sensitivity troponin assays ‘rule-in’ and ‘rule-out’ myocardial injury at presentation (using a ‘0 hour’ blood test). Whilst these algorithms have been extensively validated prospective diagnostic studies, outcome their implementation routine clinical practice has not described. The present...
Abstract Objectives Cardiac myosin-binding protein C (cMyC) is a novel biomarker of myocardial injury, with promising role in the triage and risk stratification patients presenting acute cardiac disease. In this study, we assess weekly biological variation cMyC, to examine its potential monitoring chronic suggest analytical quality specification for routine use test clinical practice. Methods Thirty healthy volunteers were included. Non-fasting samples obtained once week ten consecutive...
Our current understanding of the pathophysiology pulmonary vascular disease is incomplete, since information about alterations vasculature in arterial hypertension (PAH) primarily provided by autopsy or tissue specimens. The aim this study was to compare distal <2 mm diameter Systemic Sclerosis (SSc) patients with (n = 17) and without 5) associated PAH using Optical Coherence Tomography during Right Heart catheterization. SSc-PAH showed significant thickening Intima Media Thickening Area...
Abstract Aims Cardiac myosin-binding protein C (cMyC) demonstrated high diagnostic accuracy for the early detection of non-ST-elevation myocardial infarction (NSTEMI). Its dynamic release kinetics may enable a 0/1h-decision algorithm that is even more effective than ESC hs-cTnT/I 0/1 h rule-in/rule-out algorithm. Methods and results In prospective international study enrolling patients presenting with suspected NSTEMI to emergency department, cMyC was measured at presentation after 1 in...
Cardiac myosin-binding protein C (cMyC) seems to be even more sensitive in the quantification of cardiomyocyte injury vs. high-sensitivity cardiac troponin, and may therefore have diagnostic prognostic utility.In a prospective multicentre study, cMyC, troponin T (hs-cTnT), N-terminal pro-B-type natriuretic peptide (NT-proBNP) plasma concentrations were measured blinded fashion patients presenting emergency department with acute dyspnoea. Two independent cardiologists centrally adjudicated...