A5003601808- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Liver Disease and Transplantation
- Transplantation: Methods and Outcomes
- Organ Donation and Transplantation
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cardiac Ischemia and Reperfusion
- Pancreatitis Pathology and Treatment
- Organ and Tissue Transplantation Research
- Immune Cell Function and Interaction
- Gallbladder and Bile Duct Disorders
- T-cell and B-cell Immunology
- Hepatocellular Carcinoma Treatment and Prognosis
- Nitric Oxide and Endothelin Effects
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal and Vascular Pathologies
- Gastric Cancer Management and Outcomes
- Neurological Complications and Syndromes
- Acute Kidney Injury Research
- Xenotransplantation and immune response
- Cytomegalovirus and herpesvirus research
- Reconstructive Surgery and Microvascular Techniques
- Pediatric Hepatobiliary Diseases and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
Innsbruck Medical University
2016-2025
Universität Innsbruck
2016-2025
Brigham and Women's Hospital
2011-2015
Harvard University
2011-2015
Charité - Universitätsmedizin Berlin
2015
University Hospital Innsbruck
2012
Zero to Three
2010
University of Pittsburgh Medical Center
2010
Center for Pediatric Endocrinology Zurich
2009
Background: Heart failure (HF) survival has improved, and nowadays, many patients with HF die of noncardiac causes, including cancer. Our aim was to investigate whether a causal relationship exists between the development Methods: induced by inflicting large anterior myocardial infarction in APC min mice, which are prone developing precancerous intestinal tumors, tumor growth measured. In addition, rule out hemodynamic impairment, heterotopic heart transplantation model used an infarcted or...
Normothermic machine perfusion (NMP) has emerged as an innovative organ preservation technique. Developing understanding for the donor immune cell composition and its dynamic changes during NMP is essential. We aimed a comprehensive characterization of (sub)populations, trafficking cytokine release liver NMP. Single-cell transcriptome profiling human livers prior to, after transplantation shows abundance CXC chemokine receptor 1+/2+ (CXCR1+/CXCR2+) neutrophils, which significantly decreased...
Background. Normothermic machine perfusion (NMP) bears the potential for significant prolongation of liver preservation before transplantation. Although safety and feasibility have been recently published, no data are available describing challenges establishing NMP programs outside clinical studies. We herein present our experience propose a multidisciplinary approach in routine. Methods. In February 2018, was introduced routine use marginal organs, logistic challenges, complex recipients...
Given the susceptibility of organs to ischaemic injury, alternative preservation methods static cold storage (SCS), such as normothermic machine perfusion (NMP) are emerging. The aim this study was perform a comparison between NMP and SCS in liver transplantation with particular attention bile duct lesions.The outcomes 59 consecutive NMP-preserved donor livers were compared 1 : propensity score-matched fashion control livers. Postoperative complications, patient survival, graft survival...
To report outcomes from routine clinical practice of liver transplantation (LT) following normothermic machine perfusion (NLMP) and compare to LT after static cold storage (SCS). NLMP is emerging as a in has recently received renewed attention, however outside trials are lacking. All adult between February 2018 January 2023 were included. Comprehensive viability assessment was applied during NLMP. Outcomes compared SCS recipients, well benchmark non-benchmark cases. Of the 332 included, 174...
Liver transplantation (LT) is potentially curative for patients with cirrhosis and hepatocellular carcinoma (HCC). However, this procedure usually reserved early tumor stages or after successful downstaging local regional therapies. In locally advanced HCC, current guidelines recommend locoregional palliative systemic therapies Barcelona Clinic Cancer (BCLC) B C, respectively.In article, we describe a 63-year-old male patient HCC (BCLC C) hepatitis C-associated cirrhosis. Following treatment...
Costimulatory blockade of CD28-B7 interaction with CTLA4Ig is a well-established strategy to induce transplantation tolerance. Although previous in vitro studies suggest that upregulates expression the immunoregulatory enzyme IDO dendritic cells, relationship and vivo organ remains unclear. In this study, we studied whether concerted immunomodulation by depends on IDO. C57BL/6 recipients receiving fully MHC-mismatched BALB/c heart graft treated + donor-specific transfusion showed indefinite...
Background Simultaneous pancreas-kidney (SPK) transplantation is widely accepted as an optimal therapeutic option for patients with type 1 diabetes mellitus (T1DM) and end-stage renal disease, but the indication 2 (T2DM) still controversially discussed. Methods Twenty-one T2DM recipients of a first combined graft performed at our center during 9-year period were retrospectively analyzed regard to demographic characteristics; cardiovascular risk factors; surgical, immunological, infectious...
Normothermic machine perfusion (NMP) has become a clinically established tool to preserve livers in near-physiological environment. However, little is known about the predictive value of perfusate parameters toward outcomes after transplantation.Fifty-five consecutive NMP between 2018 and 2019 were included. All perfused on OrganOx metra device according an institutional protocol. Transplant data collected prospectively.Forty-five transplanted NMP. Five stem from donors circulatory death 31...
BackgroundThe mixed chimerism approach induces donor-specific tolerance in both pre-clinical models and clinical pilot trials. However, chronic rejection of heart allografts acute skin were observed some chimeric animals despite persistent hematopoietic toward donor antigens vitro. We tested whether additional cell therapy with regulatory T cells (Tregs) is able to induce full immunologic prevent rejection.MethodsWe recently developed a murine "Treg bone marrow (BM) transplantation (BMT)...
Management of benign liver tumours (BLT) is still object discussion. Uncertainty exists about patient selection, details management, indications for surgical intervention and potential surgery-related complications. The up-to-date strategies management the most common solid are recapitulated in this article. In addition, recommendations concerning practical issues presented. Available data from peer-reviewed publications associated with major controversies treatment BLT were selected through...
Organ transplantation has seen an increased use of organs from older donors over the past decades in attempt to meet globally growing shortage donor organs. However, inferior outcomes when are used represent a challenge.
A comparative analysis of inflammation between solid organs following donor brain death (BD) is still lacking and the detailed influence BD accelerating ischaemia–reperfusion injury (IRI) post-transplantation remains to be addressed. Applying a murine model BD, we demonstrated that 4 h after were characterized by distinct inflammatory expression patterns. For instance, lipocalin 2 (LCN2), marker acute kidney injury, was selectively induced in livers but not kidneys. further resulted...
<h2>Summary</h2> Liver transplantation (LT) was originally described by Starzl as a promising strategy to treat primary malignancies of the liver. Confronted with high recurrence rates, indications drifted towards non-oncologic liver diseases LT finally evolving from high-risk surgery an almost routine surgical procedure. Continuously improving outcomes following and oncological treatment strategies have driven renewed interest in transplant oncology. This is not only reflected constant...
Normothermic liver machine perfusion (NLMP) is advancing the field of transplantation (LT). Beyond improved preservation and organ assessment, NLMP helps to increase utilization. We herein address feasibility merit in split (SLT) postpone second graft following day.
Although percutaneous biopsies are considered to be the gold standard in diagnosing pancreas graft rejection, they not performed routinely because of their association with severe complications. On other hand, correct diagnosis rejection is essential but may difficult cases enteric drainage, particularly patients a transplant alone or after kidney transplant.Pancreas recipients who underwent enteroscopy between May 2005 and September 2009 were included this retrospective analysis. Biopsies...
Primary focal segmental glomerulosclerosis (FSGS) recurs in up to 55% of patients after kidney transplantation. Herein we report the successful management recurrent FSGS. A 5-year-old boy with primary FSGS received a deceased donor renal transplant. Immediate and fulminant recurrence caused anuric graft failure that was resistant plasmapheresis rituximab. After exclusion structural or immunologic damage by repeated biopsies, allograft retrieved from first recipient on day 27 transplanted...