A5019482120- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Epigenetics and DNA Methylation
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Fuel Cells and Related Materials
- Genetic and Kidney Cyst Diseases
- Machine Learning in Materials Science
- Cancer Immunotherapy and Biomarkers
Innsbruck Medical University
2022-2024
Universität Innsbruck
2022-2024
MRC Centre for Regenerative Medicine
2024
University of Edinburgh
2024
Biliary complications are a major cause of morbidity and mortality in liver transplantation. Up to 25% patients that develop biliary require additional surgical procedures, re-transplantation or die the absence suitable regraft. Here, we investigate role primary cilium, highly-specialised sensory organelle, injury leading post-transplant complications. Human biopsies were used study structure function cilia transplant recipients (N=7) comparison with without (N=12). To biological effects...
Liver retransplantation (reLT) yields poorer outcomes than primary liver transplantation, necessitating careful patient selection to avoid futile reLT. We conducted a retrospective analysis assess reLT and identify associated risk factors. All adult patients who underwent first at the Medical University of Innsbruck from 2000 2021 (N = 111) were included. Graft- survival assessed via Kaplan-Meier plots log-rank tests. Uni- multivariate analyses performed independent predictors graft loss....
Organ quality can be assessed prior to transplantation, during normothermic machine perfusion (NMP) of the liver. Evaluation mitochondrial function by high-resolution respirometry (HRR) may serve as a viability assessment concept in this setting. Freshly collected tissue is considered optimal sample for HRR, but due technical and personnel requirements, more flexible schedulable measurements are needed. However, impact cold storage following NMP before processing biopsy samples analysis...
The majority of organs used for liver transplantation come from brain-dead donors (DBD). In order to overcome the organ shortage, increasingly donation after circulatory death (DCD) are also considered. Since normothermic machine perfusion (NMP) restores metabolic activity and allows in-depth assessment quality function prior transplantation, such may benefit NMP. We herein compare bioenergetic performance through a comprehensive evaluation mitochondria by high-resolution respirometry in...