A5037812391- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Liver Disease and Transplantation
- Machine Learning in Materials Science
- Adenosine and Purinergic Signaling
- Venous Thromboembolism Diagnosis and Management
- Fuel Cells and Related Materials
- Mast cells and histamine
- Diagnosis and Treatment of Venous Diseases
- Chemical Reactions and Isotopes
Innsbruck Medical University
2020-2024
Universität Innsbruck
2020-2024
The majority of organs used for liver transplantation come from brain-dead donors (DBD). In order to overcome the organ shortage, increasingly donation after circulatory death (DCD) are also considered. Since normothermic machine perfusion (NMP) restores metabolic activity and allows in-depth assessment quality function prior transplantation, such may benefit NMP. We herein compare bioenergetic performance through a comprehensive evaluation mitochondria by high-resolution respirometry in...
<title>Abstract</title> Administration of tetrahydrobiopterin (BH4) has been shown to attenuate acute allograft rejection in a murine heart transplantation model manner similar that cyclosporine A. However, its mechanism action on immune cells remains largely unknown. A fully MHC-mismatched (C3H/He C57BL/6) mouse transplant was used this study. The recipients were treated with BH4 or Cyclosporine six days. degree assessed by histopathological analysis, splenocytes analyzed flow cytometry,...
Background: Tetrahydrobiopterin is a naturally occurring antioxidant and vitamin-like compound which exerts immunomodulatory activities in ischemia-reperfusion injury as well acute chronic graft rejection models. While nitric oxide synthases have been shown to be involved the attenuation of allograft vasculopathy, immunosuppressive mechanisms models are still unknown. Herein, we wanted further dissect its property. Methods/Materials: A fully MHC mismatched (C3H/He C57BL/6) mouse heterotopic...