A5043321820- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Hormonal and reproductive studies
- Ubiquitin and proteasome pathways
- Bladder and Urothelial Cancer Treatments
- Cancer, Lipids, and Metabolism
- Urologic and reproductive health conditions
- Cytokine Signaling Pathways and Interactions
- Molecular Biology Techniques and Applications
- Estrogen and related hormone effects
- Mitochondrial Function and Pathology
- Chemokine receptors and signaling
- Inflammatory mediators and NSAID effects
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- RNA modifications and cancer
- Ultrasound Imaging and Elastography
- Flexible and Reconfigurable Manufacturing Systems
- Digital Transformation in Industry
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Growth Hormone and Insulin-like Growth Factors
Innsbruck Medical University
2016-2025
Salzburg University of Applied Sciences
2022-2024
Universität Innsbruck
2014-2024
Institute of Automation
2024
Cornell University
2010-2012
German Cancer Research Center
2012
National Center for Tumor Diseases
2012
Heidelberg University
2012
Cancer Research Center
2012
Brigham and Women's Hospital
2010
Docetaxel is a standard chemotherapy for patients with metastatic prostate cancer. However, the response rather limited and not all of benefit from this treatment. To uncover key mechanisms docetaxel insensitivity in cancer, we have established docetaxel-resistant sublines. In study, report that cells underwent an epithelial-to-mesenchymal transition during selection process, leading to diminished E-cadherin levels up-regulation mesenchymal markers. Screening regulators epithelial phenotype...
Abstract Background Crosstalk between neoplastic and stromal cells fosters prostate cancer (PCa) progression dissemination. Insight in cell-to-cell communication networks provides new therapeutic avenues to mold processes that contribute PCa tumor microenvironment (TME) alterations. Here we performed a detailed characterization of endothelial (TEC) delineate intercellular crosstalk TEC the TME. Methods isolated from 67 fresh radical prostatectomy (RP) specimens underwent multi-omic ex vivo...
Although Bacillus Calmette-Guérin (BCG) is the most successful immunotherapy for high-risk non-muscle-invasive bladder cancer, approximately 30% of patients are unresponsive to treatment. New biomarkers important identify who will benefit from BCG during a worldwide shortage. Local immune cell subsets were measured on formalin-fixed, paraffin-embedded tissue sections cancer by immunohistochemistry, using monoclonal antibodies tumor-associated macrophages (TAMs; CD68, CD163), B-lymphocytes...
Prostate cancer (PC) remains the second most common cause of cancer-related death in Western countries. A previous proteomics study suggested that nuclear membrane protein lamin A/C to be a maker discriminate low- and high-Gleason score tumors identify high-risk cancers. To characterize its function PC cells, we performed detailed expression analysis tissue explored consequences down or upregulation cells. Our results confirm an increased cancers show association with tumor cell formations...
To evaluate the feasibility of using real-time sonoelastography (RTE) for differentiation and characterization testicular lesions.Institutional review board approval was obtained this retrospective study, requirement to obtain informed consent waived. Fifty patients (mean age, 42 years; age range, 18-81 years) with lesions detected gray-scale ultrasonography (US) color and/or power Doppler US were evaluated RTE between December 2004 August 2010 assess tissue elasticity testes. Stiff or...
Abstract Rewiring of energy metabolism and adaptation mitochondria are considered to impact on prostate cancer development progression. Here, we report mitochondrial respiration, DNA mutations gene expression in paired benign/malignant human tissue samples. Results reveal reduced respiratory capacities with NADH-pathway substrates glutamate malate malignant a significant metabolic shift towards higher succinate oxidation, particularly high-grade tumors. The load potentially deleterious...
Abstract Prostate cancer (PCa) is a common and fatal type of in men. Metastatic PCa (mPCa) major factor contributing to its lethality, although the mechanisms remain poorly understood. PTEN one most frequently deleted genes mPCa. Here we show frequent genomic co-deletion STAT3 liquid biopsies patients with Loss Stat3 Pten -null mouse prostate model leads reduction LKB1/pAMPK simultaneous activation mTOR/CREB, resulting metastatic disease. However, constitutive led high levels suppressed...
OBJECTIVE To evaluate the effectiveness of a well‐controlled programme early detection and treatment prostate cancer in population Tyrol, Austria, where such was initiated 1988 prostate‐specific antigen (PSA) testing offered for free to all men aged 45–75 years from 1993. SUBJECTS AND METHODS Comparison mortality rates Tyrol rest Austria accomplished through generalized additive model. A piecewise linear change‐point Poisson regression model used compare Austria. Standardized ratios were...
Prostate cancer grading with Gleason score is an important prognostic factor. This prospective randomized study compares ultrasound systematic biopsy vs contrast enhanced color Doppler targeted for the impact on findings.We examined 690 men (mean age 56 years, range 41 to 77) a serum total prostate specific antigen of 1.25 ng/ml or greater, free-to-total ratio less than 18% and/or suspicious digital rectal examination. Contrast biopsies limited number cores (5 less) were performed in...
No AccessJournal of UrologyAdult Urology1 Sep 2010Value Real-Time Elastography Targeted Biopsy for Prostate Cancer Detection in Men With Specific Antigen 1.25 ng/ml or Greater and 4.00 Less Friedrich Aigner, Leo Pallwein, Daniel Junker, Georg Schäfer, Gregor Mikuz, Florian Pedross, Michael Josef Mitterberger, Werner Jaschke, Ethan J. Halpern, Ferdinand Frauscher AignerFriedrich Aigner Department Radiology, Medical University Innsbruck, Austria More articles by this author , PallweinLeo...
Abstract BACKGROUND AGR2 is a member of the endoplasmatic reticulum protein disulphide isomerase gene family implicated in tumor metastasis. Its expression pattern, function, and utility as marker remains to be further investigated. METHODS Using real‐time RT‐PCR immunohistochemistry, changes different stages were explored microdissected samples. transcript level urine sediments was scrutinized for suitability marker. androgen regulation function analyzed cellular prostate cancer models....
Proteomics screening methods for the identification of diagnostic and prognostic biomarkers in cancer are still lagging behind DNA- or RNA-based analysis. We used two-dimensional differential gel electrophoresis (2D-DIGE) combination with laser capture microdissection (LCM) MALDI-TOF/TOF mass spectrometry to determine differentially abundant proteins candidate prostate cancer. Paired (benign tumor) samples were isolated from 23 Gleason Score 6 (GS 6) 8 higher 8+) radical prostatectomy...
Prostate cancer development and progression are associated with alterations in expression function of elements cytokine networks, some which can activate multiple signaling pathways. Protein inhibitor activated signal transducers activators transcription (PIAS)1, a regulator signaling, may be implicated the modulation cellular events during carcinogenesis. This study was designed to investigate functional significance PIAS1 models human prostate cancer. We demonstrate for first time that...
Prostate cancer (PCa) is the most commonly diagnosed and second leading cause of male death in Western nations. Thus, new treatment modalities are urgently needed. Elevated production reactive oxygen species (ROS) by NADPH oxidase (Nox) enzymes implicated tumorigenesis prostate other tissues. However, identity Nox enzyme(s) involved carcinogenesis remains largely unknown. Analysis radical prostatectomy tissue samples benign malignant epithelial cell lines identified Nox5 as an abundantly...
Abstract The normal prostate as well early stages and advanced cancer (PCa) require a functional androgen receptor (AR) for growth survival. recent discovery of microRNAs (miRNAs) novel effector molecules AR disclosed the existence an intricate network between AR, miRNAs downstream target genes. In this study DUCaP cells, characterized by high content wild-type robust transcriptional activity, were chosen main experimental model. By integrative analysis chromatin...
// Pedro Castelo-Branco 1, 2, 3, * , Ricardo Leão 4, 5, Tatiana Lipman 1 Brittany Campbell Donghyun Lee Aryeh Price Cindy Zhang Abolfazl Heidari Derek Stephens Stefan Boerno 6 Hugo Coelho 5 Ana Gomes Celia Domingos 3 Joana D. Apolonio Georg Schäfer 11 Robert G. Bristow 7 Michal R. Schweiger 8, 9 Hamilton 4 Alexandre Zlotta 10 Arnaldo Figueiredo Helmut Klocker Holger Sültmann 12 Uri Tabori Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children,...
Carcinoma‐associated fibroblasts (CAFs) play a key onco‐supportive role during prostate cancer (PCa) development and progression. We previously reported that the reactive oxygen species (ROS)‐producing enzyme NADPH oxidase 4 (Nox4) is essential for TGFβ1‐mediated activation of primary human to CAF‐like phenotype. This study aimed further investigate functional relevance prostatic Nox4 determine whether pharmacological inhibition stromal abrogates paracrine‐mediated PCa‐relevant processes....
Abstract Motivation: Prostate cancer is the most prevalent tumor in males and its incidence expected to increase as population ages. treatable by excision if detected at an early enough stage. The challenges of diagnosis require discovery novel biomarkers tools for prostate management. Results: We developed a feature selection algorithm termed associative voting (AV) identifying biomarker candidates data measured via targeted metabolite profiling MS/MS analysis. benchmarked our against two...
Abstract Background Despite recent progress in the identification of genetic and molecular alterations prostate cancer, markers associated with tumor progression are scarce. Therefore precise diagnosis patients prognosis disease remain difficult. This study investigated novel discriminating between low highly aggressive types cancer. Results Using 52 microdissected cell populations low- high-risk tumors, we identified via global cDNA microarrays analysis almost 1200 genes being...
Background Oral squamous cell carcinoma (OSCC) is mainly caused by smoking and alcohol abuse shows a five-year survival rate of ~50%. We aimed to explore the variation somatic mitochondrial DNA (mtDNA) mutations in primary oral tumors, recurrences metastases. Methods performed an in-depth validation mtDNA next-generation sequencing (NGS) on Illumina HiSeq 2500 platform for its application cancer tissues, with goal detect low-level heteroplasmies avoid artifacts. Therefore we genotyped genome...