Monika Oberhuber
A5037711934- Cancer, Hypoxia, and Metabolism
- Cytokine Signaling Pathways and Interactions
- Cancer-related Molecular Pathways
- Glioma Diagnosis and Treatment
- interferon and immune responses
- Cancer-related gene regulation
- Cancer Research and Treatments
- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- PI3K/AKT/mTOR signaling in cancer
- Ubiquitin and proteasome pathways
- Tryptophan and brain disorders
- Dialysis and Renal Disease Management
- Historical Gender and Feminism Studies
- Metabolomics and Mass Spectrometry Studies
- Advanced Proteomics Techniques and Applications
- Gastrointestinal disorders and treatments
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- Bipolar Disorder and Treatment
- Liver Disease Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Gender Studies in Language
- Immune cells in cancer
- Mitochondrial Function and Pathology
Center For Biomarker Research In Medicine
2019-2024
Medical University of Vienna
2019-2023
Universitätszahnklinik Wien
2019
Abstract Prostate cancer (PCa) is a common and fatal type of in men. Metastatic PCa (mPCa) major factor contributing to its lethality, although the mechanisms remain poorly understood. PTEN one most frequently deleted genes mPCa. Here we show frequent genomic co-deletion STAT3 liquid biopsies patients with Loss Stat3 Pten -null mouse prostate model leads reduction LKB1/pAMPK simultaneous activation mTOR/CREB, resulting metastatic disease. However, constitutive led high levels suppressed...
Frequent truncation mutations of the histone lysine N-methyltransferase KMT2C have been detected by whole exome sequencing studies in various cancers, including malignancies prostate. However, biological consequences these alterations prostate cancer not yet elucidated.To investigate functional effects mutations, we deleted C-terminal catalytic core motif Kmt2c specifically mouse epithelium. We analysed effect SET domain deletion a Pten-deficient PCa model vivo and large number patients.We...
Abstract Background Prostate cancer develops through malignant transformation of the prostate epithelium in a stepwise, mutation-driven process. Although activator protein-1 transcription factors such as JUN have been implicated potential oncogenic drivers, molecular programs contributing to progression are not fully understood. Methods We analyzed expression clinical samples across different stages and investigated its functional role Pten -deficient mouse model. performed histopathological...
Prostate cancer (PCa) has a broad spectrum of clinical behavior; hence, biomarkers are urgently needed for risk stratification. Here, we aim to find potential stratification, by utilizing gene co-expression network transcriptomics data in addition laser-microdissected proteomics from human and murine prostate FFPE samples. We show up-regulation oxidative phosphorylation (OXPHOS) PCa on the transcriptomic level TCA cycle/OXPHOS proteomic level, which is inversely correlated STAT3 expression....
Abstract Background Novel approaches to guide personalized treatment in glioblastoma are urgently needed. Given the poor predictive value of genetic biomarkers glioblastoma, we conducting a prospective clinical trial investigate novel approach cultivated patient-derived tumor cells (PDCs) for ex vivo drug screening. Methods In this randomized phase 2 study, testing ability PDC-based screening formulate recommendation maintenance patients with newly diagnosed unmethylated MGMT promoter after...
Prostate cancer ranks as the second most frequently diagnosed in men worldwide. Recent research highlights crucial roles IL6ST-mediated signaling pathways play development and progression of various cancers, particularly through hyperactivated STAT3 signaling. However, molecular programs mediated by IL6ST/STAT3 prostate are poorly understood.
Coronavirus disease 2019 (COVID-19)-induced metabolic alterations have been proposed as a source for prognostic biomarkers and may harbor potential therapeutic exploitation. However, the impact of COVID-19 in hemodialysis (HD), setting profound priori alterations, remains unstudied. To evaluate end-stage kidney (CKD G5), we analyzed plasma metabolites different stages patients with or without HD. We recruited 18 9 asymptomatic mild, 11 moderate, 2 13 severely affected, 10 6 uninfected HD...
Abstract Prostate cancer ranks as the second most frequently diagnosed in men worldwide. Recent research highlights crucial roles GP130-mediated signaling pathways play development and progression of various cancers, particularly through hyperactivated STAT3 signaling. Here, we find that genetic cell-autonomous activation GP130 receptor prostate epithelial cells triggers active significantly reduces tumor growth vivo . Mechanistically, mediates senescence via STAT3/ARF/p53 axis anti-tumor...
Introduction & Objective: Metabolic reprogramming has a critical role in the differentiation and function of PBMCs autoimmune diseases. Here, comparative cellular immune-metabolomics was applied to multiple sclerosis (MS), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) T1D. Methods: were isolated from healthy individuals (CTRLs, n=10), patients with T1D (n=11), MS (n=8), RA (n=14) SLE (n=10). Obtained either T cell-stimulated using anti-CD3/CD28 dynabeads or treated...
Abstract Background Prostate cancer develops through malignant transformation of the prostate epithelium in a stepwise, mutation-driven process. Although activator protein-1 transcription factors such as JUN have been implicated potential oncogenic drivers, molecular programs contributing to progression are not fully understood. Methods We analyzed expression clinical samples across different stages and investigated its functional role Pten -deficient mouse model. performed histopathological...
Abstract Prostate cancer (PCa) has a broad spectrum of clinical behaviour, hence biomarkers are urgently needed for risk stratification. We previously described the protective effect STAT3 in prostate mouse model. By utilizing gene co-expression network addition to laser microdissected proteomics from human and murine FFPE samples, we describe STAT3-induced downregulation TCA cycle/OXPHOS PCa on transcriptomic proteomic level. identify pyruvate dehydrogenase kinase 4 (PDK4), key regulator...
Abstract BACKGROUND AND AIMS The ongoing coronavirus disease 2019 (COVID-19) pandemic presents a major health and economical challenge. Chronic kidney (CKD) patients on haemodialysis (HDp) are at particularly high risk of severe fatal courses [1]. COVID-19 metabolome is distinct [2] may harbour potential prognostic markers therapeutic targets. However, the in SARS-CoV-2 infected HDp remains unstudied. METHOD Untargeted targeted metabolomics via high-performance liquid chromatography tandem...
Abstract Prostate cancer (PCa) lethality is driven by its progression to a metastatic castration-resistant state, yet the signaling mechanisms underlying spread remain unknown. Here we show that STAT3 converges with LKB1/mTORC1 and CREB control disease in PCa mouse models. Unexpectedly, was found be upregulated diabetic patients undergoing metformin therapy concomitant reduction mTORC1 expression. In preclinical models of PCa, genetic ablation or activation had opposing effects on...
Abstract Background Precision oncology aims to provide individual treatment options for each patient. In this regard, ex vivo drug screening systems have the potential improve clinical outcomes. Traditionally, cancer drugs are tested on long-term cultured cell line models, but lines cannot represent an patient from a clinic and biologically too distinct be informative purposes. Drug of tumor cells usually rely viability assays correlations genomic alterations. Beside alterations, cellular...
Abstract BACKGROUND In precision oncology ex vivo drug screening systems have the potential to improve clinical outcomes. Traditionally, cancer drugs are tested on cell line models, but these cannot represent an individual patient and biologically too distinct. Drug usually rely viability assays correlations genomic alterations. Beside alterations, cellular metabolism is significantly altered which may lead resistance. Here we aim establish a platform using tumor cells derived directly from...