A5038414691- Cytokine Signaling Pathways and Interactions
- Cancer-related gene regulation
- interferon and immune responses
- Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Radiopharmaceutical Chemistry and Applications
- Epigenetics and DNA Methylation
- Prostate Cancer Treatment and Research
- Microplastics and Plastic Pollution
- Immune Cell Function and Interaction
- Biosensors and Analytical Detection
- RNA modifications and cancer
- PI3K/AKT/mTOR signaling in cancer
- Dental materials and restorations
- Chemical Reactions and Isotopes
- Immune cells in cancer
- Machine Learning in Materials Science
- Recycling and Waste Management Techniques
- Viral-associated cancers and disorders
- Estrogen and related hormone effects
- Cancer, Lipids, and Metabolism
- PARP inhibition in cancer therapy
- Effects and risks of endocrine disrupting chemicals
Center For Biomarker Research In Medicine
2022-2025
Medical University of Vienna
2018-2024
Ludwig Boltzmann Institute for Cancer Research
2018
Frequent truncation mutations of the histone lysine N-methyltransferase KMT2C have been detected by whole exome sequencing studies in various cancers, including malignancies prostate. However, biological consequences these alterations prostate cancer not yet elucidated.To investigate functional effects mutations, we deleted C-terminal catalytic core motif Kmt2c specifically mouse epithelium. We analysed effect SET domain deletion a Pten-deficient PCa model vivo and large number patients.We...
Abstract Background Prostate cancer develops through malignant transformation of the prostate epithelium in a stepwise, mutation-driven process. Although activator protein-1 transcription factors such as JUN have been implicated potential oncogenic drivers, molecular programs contributing to progression are not fully understood. Methods We analyzed expression clinical samples across different stages and investigated its functional role Pten -deficient mouse model. performed histopathological...
Prostate cancer (PCa) has a broad spectrum of clinical behavior; hence, biomarkers are urgently needed for risk stratification. Here, we aim to find potential stratification, by utilizing gene co-expression network transcriptomics data in addition laser-microdissected proteomics from human and murine prostate FFPE samples. We show up-regulation oxidative phosphorylation (OXPHOS) PCa on the transcriptomic level TCA cycle/OXPHOS proteomic level, which is inversely correlated STAT3 expression....
TYK2 is a member of the JAK family tyrosine kinases that involved in chromosomal translocation-induced fusion proteins found anaplastic large cell lymphomas (ALCL) lack rearrangements activating lymphoma kinase (ALK). Here we demonstrate highly expressed all cases human ALCL, and mouse model NPM-ALK-induced lymphoma, genetic disruption Tyk2 delays onset tumors prolongs survival mice. Lymphomas this lacking have reduced STAT1 STAT3 phosphorylation expression Mcl1, pro-survival BCL2 family....
Abstract Background Anaplastic large cell lymphoma (ALCL) is an aggressive non-Hodgkin T commonly driven by NPM-ALK. AP-1 transcription factors, cJUN and JUNb, act as downstream effectors of NPM-ALK transcriptionally regulate PDGFRβ. Blocking PDGFRβ kinase activity with imatinib effectively reduces tumor burden prolongs survival, although the molecular mechanisms remain elusive. Methods results In a transgenic mouse model that mimics PDGFRβ-driven human ALCL in vivo, we identify driver...
Prostate cancer ranks as the second most frequently diagnosed in men worldwide. Recent research highlights crucial roles IL6ST-mediated signaling pathways play development and progression of various cancers, particularly through hyperactivated STAT3 signaling. However, molecular programs mediated by IL6ST/STAT3 prostate are poorly understood.
ABSTRACT Microplastic (MP) pollution has emerged as a significant environmental and health concern. This study aimed at developing novel method for detecting MP particles in deparaffinized formalin-fixed paraffin-embedded (FFPE) routine tissue sections of human colon samples. By utilizing mid-infrared photothermal (MIP) microscopy, also known optical infrared (OPTIR) spectroscopy, we here to establish work-flow representing non-destructive spectroscopic approach distinct identification...
Prostate cancer (PCa) is the second most common in men and shows high inter- intra-patient heterogeneity. Consequently, treatment options are limited there a lack of representative preclinical models. Here we establish comprehensive biobank murine organoids tumoroids that reflect patient mutations. We demonstrate deletion Pten alone, or combination with Stat3, Tp53, drives activation cancer-related pathways both prostate tumour-derived tumoroids. A medium-throughput drug screen identified...
A substantial portion of patients do not benefit from programmed cell death protein 1/programmed 1 ligand (PD-1/PD-L1) checkpoint inhibition therapies, necessitating a deeper understanding predictive biomarkers. Immunohistochemistry (IHC) has played pivotal role in assessing PD-L1 expression, but small-molecule positron emission tomography (PET) tracers could offer promising avenue to address IHC-associated limitations, i.e., invasiveness and expression heterogeneity. PET would allow for...
Abstract Prostate cancer ranks as the second most frequently diagnosed in men worldwide. Recent research highlights crucial roles GP130-mediated signaling pathways play development and progression of various cancers, particularly through hyperactivated STAT3 signaling. Here, we find that genetic cell-autonomous activation GP130 receptor prostate epithelial cells triggers active significantly reduces tumor growth vivo . Mechanistically, mediates senescence via STAT3/ARF/p53 axis anti-tumor...
ABSTRACT In this study, we investigate the efficacy of Optical Photothermal Infrared (O-PTIR) spectroscopy, also known as mid-infrared photothermal (MIP) microscopy, for detection micro- and nano plastics (MNPs) down to diameters 250 nm in mammalian tissues. Experiments with both vitro 3D cell cultures derived from HTC116 colorectal cancer line vivo mouse tissue models were conducted evaluate spatial resolution limits quality spectra that formed basis label-free non- destructive...
Abstract Background Prostate cancer develops through malignant transformation of the prostate epithelium in a stepwise, mutation-driven process. Although activator protein-1 transcription factors such as JUN have been implicated potential oncogenic drivers, molecular programs contributing to progression are not fully understood. Methods We analyzed expression clinical samples across different stages and investigated its functional role Pten -deficient mouse model. performed histopathological...
Introduction Prostate cancer (PCa) is the most frequently diagnosed malignancy in men and ranks as third leading cause of cancer-related death Western civilization. There an urgent need to provide diagnostic tools able reliably stratify aggressive from slow progressing tumours. As a result, over-diagnosis PCa remains prevalent issue patients suffer severe side effects following therapeutic intervention. Recently, whole-exome sequencing has identified MLL family member KMT2C amongst mutated...