A5042454161- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Acute Ischemic Stroke Management
- Ultrasound Imaging and Elastography
- Atrial Fibrillation Management and Outcomes
- Neurological Disease Mechanisms and Treatments
- Cardiac Imaging and Diagnostics
- Takotsubo Cardiomyopathy and Associated Phenomena
- Innovations in Medical Education
- Global Health Workforce Issues
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Structural Anomalies and Repair
- Stroke Rehabilitation and Recovery
- Acute Myocardial Infarction Research
- Advanced Neuroimaging Techniques and Applications
- Neurological Complications and Syndromes
- Hip and Femur Fractures
- Advances in Oncology and Radiotherapy
- Biomedical and Engineering Education
- Infrared Thermography in Medicine
- Healthcare Policy and Management
- Cardiac Arrhythmias and Treatments
- Lung Cancer Treatments and Mutations
- Image Processing Techniques and Applications
- Primary Care and Health Outcomes
Brainomix (United Kingdom)
2024-2025
Oxford University Hospitals NHS Trust
2024
John Radcliffe Hospital
2023-2024
University of Oxford
2019-2024
University of Leicester
2012-2018
University of Southampton
2017-2018
Shear Wave Elastography (SWE) imaging is a novel ultrasound technique for quantifying tissue elasticity. Studies have demonstrated that SWE able to differentiate between diseased and normal in wide range clinical applications. However its applicability atherosclerotic carotid disease has not been established. The aim of this study was assess the feasibility potential benefit using assessment plaques. Eighty-one patients (mean age 76 years, 51 male) underwent greyscale imaging. Elasticity...
<b>Purpose:</b> There is a need to develop methods that reliably quantify characteristics associated with vulnerable carotid plaque. Greyscale median (GSM) and shear wave elastography (SWE) are two techniques may improve individual plaque risk stratification. SWE, which quantifies Young's Modulus (YM) estimate tissue stiffness, has been researched in the liver, breast, thyroid prostate, but its use plaques novel. <b>Materials Methods:</b> The aim of this study was YM GSM compare histology....
Background: Identifying optimal candidates for endovascular treatment (EVT) remains an ongoing priority to maximize efficacy. The recent large core trials have called into question the use of infarct volume alone selecting patients. This study aimed at exploring feasibility using routinely acquired Computed Tomography Perfusion (CTP) capture how lesion location impacts brain connectivity and this in turn affects ability benefit from EVT. Methods: Consecutive patients a multi-centric stroke...
Background: There is an unmet need to better understand the likelihood of a good functional outcome in older and frailer populations undergoing endovascular therapy (EVT) following large-vessel occlusion (LVO) ischemic stroke. One approach improve understanding pre-morbid brain health (“brain frailty”) as predictor outcome. This study explored relationship between spatial pattern atrophy determine whether this outcomes EVT. Methods: Patients with LVO from four hospitals Europe USA were...
Follow-up infarct volume (FIV) is a proposed surrogate endpoint for proof-of-concept clinical studies in acute ischemic stroke (AIS). This study aimed to provide validation of an automated FIV algorithm, demonstrating the association imaging biomarkers with outcomes support use these endpoints trials. Data were gathered adult AIS patients undergoing mechanical thrombectomy follow-up 12-96 h from initial assessment. Non-contrast computed tomography was used quantify volume. Image processing...
The current selection of patients for carotid endarterectomy surgery is heavily reliant on the degree stenosis. However, this a poor individual marker (P Rothwell et al. Lancet 2004; 363: 915–924). This case report utilized novel ultrasound imaging technique called shear-wave elastography, which quantifies Young’s Modulus (YM) tissue. Clinical studies using elastography have focused assessment malignancy (D Cosgrove Ultraschall in Med. 2013; 34: 238–253). its use plaque novel. We consider...
Objective Takotsubo syndrome (TTS) is an acute heart failure which resembles coronary (ACS) at presentation. Differentiation requires angiography, but where this does not occur immediately, cardiac biomarkers may provide additional utility. We performed a meta-analysis to compare troponin and natriuretic peptides (NPs) in TTS ACS determine if differences biomarker profile can aid diagnosis. Methods searched five literature databases for studies reporting NPs (Brain NP (BNP)/NT-pro-BNP) or...
Arterial Spin Labelling (ASL) imaging derives a perfusion image by tracing the accumulation of magnetically labeled blood water in brain. As generated has an intrinsically low signal to noise ratio (SNR), multiple measurements are routinely acquired and averaged, at penalty increased scan duration opportunity for motion artefact. However, this strategy alone might be ineffective clinical settings where time available acquisition is limited patient increased. This study investigates use...
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No country has yet established a national screening programme (NSP) for atrial fibrillation (AF), including the UK.However, there is an increasing body of evidence suggesting may be beneficial, prompting recommendations from prominent expert bodies to screen AF. 1 Despite these data, UK National Screening Committee (NSC) not recommended systematic population screening.The review in 2014 concluded '… it clear that those identified as at risk through would benefit early diagnosis'. 2 The NSC...
Background Identifying eloquent regions associated with poor outcomes based on CT perfusion (CTP) may help inform personalized decisions selection for endovascular therapy (EVT) in patients large vessel occlusion (LVO) ischemic stroke. This study aimed to characterize the relationship between CTP-defined hypoperfusion and National Institutes of Health Stroke Scale (NIHSS) subitem deficits. Methods Patients anterior circulation LVO, baseline CTP, itemized NIHSS at presentation 24 hours were...
Abstract Background Takotsubo syndrome (TTS) is an acute heart failure which resembles coronary (ACS) at presentation. Differentiation requires angiography, but where this does not occur immediately, cardiac biomarkers may provide additional utility. We performed a meta-analysis to compare troponin and natriuretic peptides (NPs) in TTS ACS determine if differences biomarker profile can aid diagnosis. Methods searched five literature databases for studies reporting NPs (BNP/NT-pro-BNP) or I/T...
Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal and information, but is committed maintaining privacy will not share personal information without express consent. For more please refer our Privacy Policy. eTOC Secondary Logo Journal All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Login & Issues Current IssuePrevious IssuesPublished Ahead-of-Print Collections...
Abstract Background Physical motion throughout the cardiac cycle may contribute to rupture of atherosclerotic carotid plaque, resulting in ischaemic stroke. The purpose this study was quantify physiological plaque and investigate any relationship between quantified parameters degree stenosis, greyscale characteristics, presence cerebrovascular symptoms. Methods Displacement, velocity acceleration 81 plaques (51% symptomatic, stenosis range 10%-95%) from 51 patients were measured using an...