A5047137567- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Peripheral Artery Disease Management
- Neurological Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Health and Disease Prevention
- Trauma and Emergency Care Studies
- Cardiovascular Syncope and Autonomic Disorders
- Intracranial Aneurysms: Treatment and Complications
- Dysphagia Assessment and Management
- Tracheal and airway disorders
- Multiple Sclerosis Research Studies
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disease Mechanisms and Treatments
- Esophageal and GI Pathology
- Climate Change and Health Impacts
- Cellular transport and secretion
- Blood Pressure and Hypertension Studies
- Sympathectomy and Hyperhidrosis Treatments
- Long-Term Effects of COVID-19
University of Ostrava
2018-2025
Městská Nemocnice Ostrava
2025
University Hospital Hradec Králové
2023-2024
University of Calgary
2020-2024
Vitkovice - Research and Development (Czechia)
2008-2024
Charles University
2015-2024
Bayer (Germany)
2024
University Hospital Ostrava
2022-2023
University of Hradec Králové
2022
Hospital de Clínicas de Porto Alegre
2021
<h3>Objective:</h3> To evaluate the effects of oral delayed-release dimethyl fumarate (DMF; also known as gastro-resistant DMF) on MRI lesion activity and load, atrophy, magnetization transfer ratio (MTR) measures from Comparator an Oral Fumarate in Relapsing-Remitting Multiple Sclerosis (CONFIRM) study. <h3>Methods:</h3> CONFIRM was a 2-year, placebo-controlled study efficacy safety DMF 240 mg twice (BID) or 3 times daily (TID) 1,417 patients with relapsing-remitting multiple sclerosis...
Stroke treatment is time-dependent, yet no study has systematically examined response to individual stroke symptoms in the general population. This nationwide identifies which specific factors prompt correct (calling 911) stroke.Between November and December of 2005, a survey using 3-stage random-sampling method including area, household, household member sampling was conducted throughout Czech Republic. Participants >40 years old were personally interviewed via structured standardized...
Little is known about the effect of thrombolysis in patients with preexisting disability. Our aim was to evaluate impact different levels prestroke disability on patients' profile and outcome after intravenous thrombolysis.We analyzed data all stroke admitted between October 2003 December 2011 that were contributed Safe Implementation Treatments Stroke-Eastern Europe (SITS-EAST) registry. Patients no at (modified Rankin Scale [mRS] score, 0) used as a reference multivariable logistic...
To undertake an effectiveness and safety analysis of EVT in patients with LVO NIH Stroke Scale (NIHSS) score ≤6 using datasets multicenter multinational nature.We pooled anterior circulation occlusion from 3 prospective international cohorts. Patients were eligible if presentation occurred within 12 hours last known well baseline NIHSS ≤6. Primary outcome was modified Rankin (mRS) 0-1 at 90 days. Secondary outcomes included neurologic deterioration 24 (change ≥2 points), mRS 0-2 days, 90-day...
Background: Acute stroke lesions become more hypodense on non-contrast CT as the ischemic injury matures. Lesions transition to established infarcts at which time recanalization treatment is thought be futile, if not harmful. As it possible directly quantify degree of progression, eligibility for determined using temporal criteria. In this study we used an AI approach segment and hypoattenuation acute baseline CTs, explored its impact clinical outcome following mechanical thrombectomy....
Follow-up infarct volume (FIV) is a proposed surrogate endpoint for proof-of-concept clinical studies in acute ischemic stroke (AIS). This study aimed to provide validation of an automated FIV algorithm, demonstrating the association imaging biomarkers with outcomes support use these endpoints trials. Data were gathered adult AIS patients undergoing mechanical thrombectomy follow-up 12-96 h from initial assessment. Non-contrast computed tomography was used quantify volume. Image processing...
Abstract Background and Purpose Mechanical thrombectomy ( MT ) is indicated for the treatment of large vessel occlusion LVO stroke. should be provided as quickly possible; therefore, a test identifying suspected in prehospitalization stage needed to ensure direct transport comprehensive stroke center CSC ). We assume that patients with clinically severe hemiparesis have high probability modified FAST into PLUS test: The first part second evaluates presence arm or leg motor deficit. This...
Knowledge of the implementation gap would facilitate use intravenous thrombolysis in stroke, which is still low many countries. The study was conducted to identify national targets for utilisation and logistics thrombolysis.Multicomponent interventions by stakeholders health care optimise prehospital hospital management with goal fast accessible every candidate. Implementation results were documented from prospectively collected cases all 45 stroke centres nationally. thrombolytic rate...
According to the European license, alteplase can be given no sooner than 3 months after previous stroke. However, it is not known whether past history of stroke influences effect treatment. Our aim was evaluate safety and functional outcome intravenous thrombolysis administered in everyday practice patients with stroke≤3 compared those first-ever stroke.We analyzed consecutive cases treated between October 2003 July 2014 contributed Safe Implementation Thrombolysis for Stroke-Eastern Europe...
Cardioembolic stroke (CS) in patients without thrombolytic treatment is associated with a worse clinical outcome and higher mortality compared to other types of stroke. The aim this study was determine the CS treated by intravenous thrombolysis (IVT).Data from SITS-EAST register (Safe Implementation Treatments Stroke) were analyzed who received IVT 2000 April 2014. effect etiology according ICD-10 classification on using univariate multivariate analysis. outcomes assessed as follows:...
This article describes policy processes that have led to the re-organisation of stroke care in Czech Republic since 2011, which has been part a broader process concentration several medical fields. Currently, is provided by 13 Comprehensive and 32 Primary Stroke Centres. The paper explains factors supported reform implementation, reviews implications, discusses future challenges. Mandatory reporting quality indicators, introduction benchmarking system, integration with pre-hospital emergency...
Background and aims Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by disease-associated variants in the alpha-galactosidase A gene ( GLA ). FD known cause of stroke younger patients. There are limited data on prevalence risk unselected Methods prospective nationwide study including 35 (78%) all 45 centers consecutive patients admitted during three months. Clinical were collected RES-Q database. was diagnosed using dried blood spots stepwise manner: males—enzymatic...
The coexistence of underlying causes in patients with transient ischemic attack (TIA) or minor stroke as well their associated 5-year risks are not known.
Background and Purpose: Ischemic stroke is a leading cause of mortality morbidity worldwide. The time from onset to treatment impacts clinical outcome. Here, we examined whether changing triage model “drip ship” “mothership” yielded significant reductions onset-to-groin (OGT) in patients receiving EVT onset-to-needle (ONT) IVT-treated patients, compared before FAST-PLUS test implementation. We also investigated the new improved outcomes. Methods: In before/after multicenter study, evaluated...
Background The benefit of intravenous thrombolysis is time dependent. It remains unclear, however, whether dramatic shortening door-to-needle (DNT) among different types hospitals nationwide does not compromise safety and still improves outcome. Methods Results Multifaceted intervention to shorten DNT was introduced at a national level, prospectively collected data from registry between 2004 2019 were analyzed. Generalized estimating equation used identify the association outcomes...
The safety and efficacy of intravenous thrombolysis (IVT) are well established in anterior circulation stroke (ACS) but much less clear for posterior (PCS). aim this study was to evaluate the occurrence parenchymal hematoma (PH) 3-month clinical outcomes after IVT PCS ACS. In an observational, cohort multicenter study, we analyzed data from ischemic patients treated with prospectively collected SITS (Safe Implementation Treatments Stroke) registry Czech Republic between 2004 2018. Out 10,211...
Background and aim In-stent restenosis (ISR) belongs to an infrequent but potentially serious complication after carotid angioplasty stenting in patients with severe stenosis. Some of these might be contraindicated repeat percutaneous transluminal or without (rePTA/S). The purpose the study is compare safety effectiveness endarterectomy stent removal (CEASR) rePTA/S ISR. Methods Consecutive ISR (≥80%) were randomly allocated CEASR group. incidence intervention, stroke, transient ischaemic...