A5004836848- Botulinum Toxin and Related Neurological Disorders
- Neurological disorders and treatments
- Stroke Rehabilitation and Recovery
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Advanced Neuroimaging Techniques and Applications
- Acute Ischemic Stroke Management
- Cervical and Thoracic Myelopathy
- Alzheimer's disease research and treatments
- Motor Control and Adaptation
- EEG and Brain-Computer Interfaces
- Genetic Neurodegenerative Diseases
- Cerebrovascular and Carotid Artery Diseases
- Urban Stormwater Management Solutions
- Advanced MRI Techniques and Applications
- Neurological Disorders and Treatments
- Action Observation and Synchronization
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Water Systems and Optimization
- Multiple Sclerosis Research Studies
- Spinal Fractures and Fixation Techniques
- Clusterin in disease pathology
- Spinal Dysraphism and Malformations
- Vestibular and auditory disorders
University Hospital Olomouc
2015-2024
Palacký University Olomouc
2015-2024
Brno University of Technology
2013-2023
Neurology, Inc
2023
University Hospital Brno
2022
Central European Institute of Technology
2022
Ministry of Health
2018
University Hospital Plzen
2015
University Hospital Ostrava
2007-2009
ZZN Pelhřimov (Czechia)
2009
Motor imagery, the 'mental rehearsal of motor acts without overt movements', involves either a visual representation (visual VI) or mental simulation movement, associated with kinesthetic feeling (kinetic KI). Previous brain imaging work suggests that patterns activation differ when comparing execution (E) type imagery but functional connectivity participating networks has not been studied. Using magnetic resonance (fMRI) and structural equation modeling, this study elucidates...
An experimental lesion in the primary motor or sensory cortices monkeys leads to functional reorganization areas surrounding contralateral homologous regions. In humans, task‐dependent brain activation after stroke seems be multifocal and bilateral. Although many active structures are seen stroke, their roles unclear. For instance, uninjured cortex may play a significant role recovery associated with mirror movements. Other areas, particularly those outside affected middle cerebral artery...
High-resolution functional magnetic resonance imaging of healthy volunteers was used to study the anatomy human primary motor (M1) and somatosensory (S1) cortical hand representations during simple movements thumb, little finger wrist a sequential movement middle three fingers. Rest served as control state. The results demonstrated an orderly somatotopy in both M1 S1, even though areas active with individual significantly overlapped. Moreover, activation patterns S1 differed aspects: (i)...
Although functional lateralization in the human brain has been studied intensively, there remains significant controversy over mechanisms that instantiate it. The main objective of present study is to characterize regions associated with generation different movements by fingers both hands right- and left-handed people. Thirteen left-handers were using blood oxygen level dependent (BOLD) magnetic resonance imaging (fMRI) during performance single sequential finger movement tasks. We used...
The objective of this paper was to analyze the temporal and spatial trends in annual seasonal precipitation Slovakia utilizing 487 gauging station data collected statewide period from 1981 2013. nonparametric Mann–Kendall (MK) statistical test, which has been widely used assess significance hydrological time series, applied detect significant trends. Theil–Sen (TS) approach quantify trend magnitude, Sequential (SQMK) test abrupt shifts. In general, study area have not changed during last 33...
The authors studied motor behavior and primary (M1) somatosensory (S1) cortical representations of movement during hand skill acquisition over 3 weeks. During four functional MRI sessions 1 week apart, subjects performed simple movements single fingers wrist, a sequential the middle three fingers, contrasted with rest. Half practiced movement, whereas other half gross task (squeezing sponge). In both groups, performance gradually improved on sequence also unrelated tests general performance....
Botulinum toxin type A (BoNT) is considered an effective therapeutic option in cervical dystonia (CD). The pathophysiology of CD and other focal dystonias has not yet been fully explained. Results from neurophysiological imaging studies suggest a significant involvement the basal ganglia thalamus, functional abnormalities premotor primary sensorimotor cortical areas are crucial factor development dystonias. Twelve BoNT-naïve patients with were examined MRI during skilled hand motor task;...
Neurodegenerative diseases are a broad heterogeneous group affecting the nervous system. They characterized, from pathophysiological perspective, by selective involvement of subpopulation nerve cells with consequent clinical picture disease. Clinical diagnoses neurodegenerative quite challenging and often not completely accurate because their marked heterogeneity frequently overlapping pictures. Efforts being made to define sufficiently specific sensitive markers for individual or groups in...
Converging data on focal dystonias suggest a widespread disorder of somatosensory processing. The aims our study were, first, to assess activation patterns in cervical dystonia (CD) beyond the representation affected body parts and, second, search for task-related changes induced by botulinum toxin type-A (BoNT-A) therapy. Functional magnetic resonance imaging (MRI) during electrical median nerve stimulation was employed seven CD patients and nine controls; examination repeated 4 weeks after...
Abstract The link between dystonia and tremor has been known for decades, but the question of whether they are two separate illnesses or just different manifestations one disease with same pathophysiological background remains unanswered. We distinguish types in dystonia: dystonic (DT), which appears on body part affected by dystonia, associated (TAWD), locations where does not occur. In this study, frequency occurrence forms was determined clinical examination a group adult-onset isolated...
ABSTRACT Substantia nigra (SN) was assessed by transcranial sonography (TCS) in 47 Parkinson's disease (PD) patients and 39 healthy volunteers. A semiquantitative echogenicity scale created with arbitrary values ranging from 1 to 5, zones grade ≥3 larger than 0.19 cm 2 were recorded as hyperechogenic SN. TCS examination of SN a diagnostic test for PD our study showed 87.2% sensitivity 94.9% specificity.
ABSTRACT BACKGROUND AND PURPOSE Botulinum toxin (BTX) treatment can relieve focal arm spasticity after stroke, presumably through dynamic changes at multiple levels of the motor system, including cerebral cortex. However, neuroanatomical correlate BTX relief is not known and should be reflected in cortical activation during tasks assessed using repeated functional magnetic resonance imaging (fMRI). METHODS Four patients (2 males, 2 females, mean age 25.5 years) with hemiplegia distal chronic...