Charlotte Zerna
A5025499620- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Dementia and Cognitive Impairment Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Clinical practice guidelines implementation
- Neurological Disease Mechanisms and Treatments
- Peripheral Artery Disease Management
- Neurological Disorders and Treatments
- Neurological and metabolic disorders
- Medical Imaging and Analysis
- Healthcare Systems and Practices
- Antiplatelet Therapy and Cardiovascular Diseases
- Intracranial Aneurysms: Treatment and Complications
- Blood Pressure and Hypertension Studies
- Advanced X-ray and CT Imaging
- Cardiac Imaging and Diagnostics
- Blood properties and coagulation
- Cardiovascular and Diving-Related Complications
- Heparin-Induced Thrombocytopenia and Thrombosis
- Health, Environment, Cognitive Aging
- Brain Metastases and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
Städtisches Klinikum Dresden
2022-2025
University of Calgary
2015-2024
Foothills Medical Centre
2016-2021
Centre Hospitalier de l’Université de Montréal
2021
University of Toronto
2016-2020
Calgary Laboratory Services
2019-2020
Ontario Brain Institute
2019
Medanta The Medicity
2016-2018
Novartis (Canada)
2018
Laboratoire de Chimie
2018
Autopsy studies suggest that cerebral amyloid angiopathy (CAA) is associated with cognitive impairment and risk for dementia. We analyzed neuropsychological test data from a prospective cohort study of patients CAA to identify the prevalence its associations brain magnetic resonance imaging features apolipoprotein E genotype.Data were 34 CAA, 16 Alzheimer's disease, 69 mild impairment, 27 ischemic stroke participants. Neuropsychological results expressed as z scores in relation normative...
Background In this subanalysis of the TEMPO‐2 (Tenecteplase Versus Standard Care for Minor Ischaemic Stroke With Proven Occlusion) trial, a randomized clinical trial comparing tenecteplase and nonthrombolytic control in patients with minor stroke symptomatic intracranial occlusion, we investigated sex differences efficacy safety tenecteplase. Methods We compared outcomes after versus control, stratified by sex. also female male treated The primary outcome was “responder” outcome, defined as...
To evaluate whether the use of multiphase CT angiography (CTA) improves interrater agreement for intracranial occlusion detection between stroke neurology trainees and an expert neuroradiologist.A neuroradiologist 2 fellows independently reviewed 100 prospectively collected single-phase CTA scans from acute ischemic patients with mild symptoms (NIH Stroke Scale score ≤5). The presence location a vascular occlusion(s) were documented. Interrater single- was quantified using unweighted κ...
The effectiveness of specific systems changes to reduce DTN (door-to-needle) time has not been fully evaluated. We analyzed the impact 4 reduction strategies implemented prospectively in a staggered fashion.The HASTE (Hurry Acute Stroke Treatment and Evaluation) project was 3 phases at single academic medical center. In I (June 6, 2012 June 5, 2013), baseline performance analyzed. II 2013 January 24, 2015), were implemented: (1) STAT stroke protocol prenotify team about incoming patients;...
Sex differences have been described in the presentation, care, and outcomes among people with acute ischemic strokes, but these are less understood for minor cerebrovascular events. The present study hypothesized that, compared men, women more likely to report nonfocal symptoms receive a stroke mimic diagnosis.To evaluate sex symptoms, diagnoses, of patients transient or neurologic events.This prospective cohort events mimics enrolled at multicenter academic emergency departments Canada...
Background Five randomized controlled trials recently demonstrated efficacy of endovascular treatment in acute ischemic stroke. Telestroke networks can improve stroke care rural areas but their role patients undergoing is unknown. Aim We compared clinical outcomes between anterior circulation transferred after teleconsultation and those directly admitted to a tertiary center. Methods Data derived from consecutive with intracranial large vessel occlusion who underwent January 2010 December...
Background and Purpose— White matter lesions (WML) are associated with cognitive decline, increased stroke risk, disability in old age. We hypothesized that superimposed acute cerebrovascular occlusion on chronic preexisting injury (leukoaraiosis) leads to worse outcome after minor event, both using quantitative (volumetric) qualitative (Fazekas scale) assessment, as well relative total brain volume. Methods— WML volume assessment was performed 425 patients high-risk transient ischemic...
To undertake an effectiveness and safety analysis of EVT in patients with LVO NIH Stroke Scale (NIHSS) score ≤6 using datasets multicenter multinational nature.We pooled anterior circulation occlusion from 3 prospective international cohorts. Patients were eligible if presentation occurred within 12 hours last known well baseline NIHSS ≤6. Primary outcome was modified Rankin (mRS) 0-1 at 90 days. Secondary outcomes included neurologic deterioration 24 (change ≥2 points), mRS 0-2 days, 90-day...
<h3>BACKGROUND AND PURPOSE:</h3> Infarct volume is an important predictor of clinical outcome in acute stroke. We hypothesized that the association infarct and changes with magnitude size. <h3>MATERIALS METHODS:</h3> Data were derived from Safety Efficacy Nerinetide Subjects Undergoing Endovascular Thrombectomy for Stroke (ESCAPE-NA1) trial, which patients stroke large-vessel occlusion randomized to endovascular treatment plus either nerinetide or a placebo. was manually segmented on 24-hour...
Background Intracranial hemorrhage is a known complication after endovascular treatment in patients with acute ischemic stroke due to large vessel occlusion, but the association between radiologic severity and outcome controversial. Purpose To investigate prevalence impact on of intracranial treatment. Materials Methods The Efficacy Safety Nerinetide for Treatment Acute Ischemic Stroke (ESCAPE-NA1) trial enrolled participants occlusion who underwent from March 1, 2017, August 12, 2019....
Background The effect of infarct pattern on functional outcome in acute ischemic stroke is incompletely understood. Purpose To investigate the association qualitative and quantitative variables at 24-hour follow-up noncontrast CT diffusion-weighted MRI with 90-day clinical outcome. Materials Methods Safety Efficacy Nerinetide Subjects Undergoing Endovascular Thrombectomy for Stroke, or ESCAPE-NA1, randomized controlled trial enrolled patients large-vessel-occlusion undergoing mechanical...
Respiratory infection can be an immediate precursor to stroke and myocardial infarction. Influenza vaccination is associated with reduced risk of infarction hospitalisation for cardiac disease, influenza strongly recommended patients heart disease. Evidence on whether the same protective association exists stroke, this potential effect consistent across age groups, conflicting. We aimed assess after in adults.We obtained administrative data from Alberta Health Care Insurance Plan (which...
The effectiveness and safety of intravenous alteplase given before or concurrently with endovascular thrombectomy (EVT) is uncertain. Randomized clinical trials suggest there little difference in outcomes but only modest precision insufficient power to analyze uncommon including symptomatic intracranial hemorrhage (sICH).To determine whether 8 prespecified are different patients acute ischemic stroke treated routine practice EVT compared alone without alteplase. It was hypothesized that...
Background and Purpose: To compare the benefit of endovascular treatment (EVT) in acute ischemic stroke (AIS) patients with large vessel occlusion (LVO) presenting >6 hours from last known well outside a clinical trial setting to best medical management EVT randomized setting. Methods: Data retrospective multicenter cohort study (ESCAPE LATE) AIS-LVO treated beyond 6 at former ESCAPE sites were pooled historical data late time window patients. Unadjusted adjusted 90-day modified Rankin...
In the ESCAPE-NA1 (Efficacy and Safety of Nerinetide for Treatment Acute Ischaemic Stroke) trial, treatment with nerinetide was associated improved outcomes in patients who did not receive intravenous alteplase. We compared effect on clinical without concurrent alteplase within different patient subgroups. a multicenter randomized trial which acute stroke baseline Alberta Stroke Program Early CT Score (ASPECTS) >4 undergoing endovascular (EVT) were to or placebo. The primary outcome...