A5072719730- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- CRISPR and Genetic Engineering
- Stroke Rehabilitation and Recovery
- Crystallization and Solubility Studies
- COVID-19 Clinical Research Studies
- X-ray Diffraction in Crystallography
- COVID-19 and healthcare impacts
- Crystallography and molecular interactions
- Traumatic Brain Injury and Neurovascular Disturbances
- Radiation Dose and Imaging
- Neurological Disorders and Treatments
- Glioma Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Pediatric Urology and Nephrology Studies
- Protein Degradation and Inhibitors
- Cerebral Venous Sinus Thrombosis
- Histone Deacetylase Inhibitors Research
- Forensic Toxicology and Drug Analysis
- Cellular Mechanics and Interactions
- RNA modifications and cancer
- Alcoholism and Thiamine Deficiency
- Intracerebral and Subarachnoid Hemorrhage Research
- Poisoning and overdose treatments
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
University of Calgary
2015-2025
University of California, San Francisco
2023-2025
Neurological Surgery
2025
Vall d'Hebron Hospital Universitari
2024
Amherst College
2024
University of Massachusetts Amherst
2024
Centre Hospitalier de l’Université de Montréal
2023
Foothills Medical Centre
2023
Nationwide Children's Hospital
2019
The Ohio State University
2019
Emerging data suggest that direct oral anticoagulants may be a suitable choice for anticoagulation cerebral venous thrombosis (CVT). However, conducting high-quality trials in CVT is challenging as it rare disease with low rates of adverse outcomes such major bleeding and functional dependence. To facilitate the design future trials, SECRET (Study Rivaroxaban Cerebral Venous Thrombosis) assessed (1) feasibility recruitment, (2) safety rivaroxaban compared standard-of-care anticoagulation,...
Abstract Background Glioblastoma (GBM) carries a poor prognosis, and new therapeutic strategies are necessary to improve outcomes for patients with this disease. Alkylating chemotherapies including temozolomide (TMZ) lomustine (CCNU) critical treating GBM, but resistance mechanisms, hypomethylation of O6-methylguanine-DNA methyltransferase (MGMT) promoter, undermine treatment. CRISPRoff is programmable epigenetic memory editor that can induce stable heritable gene silencing after transient...
Background In this subanalysis of the TEMPO‐2 (Tenecteplase Versus Standard Care for Minor Ischaemic Stroke With Proven Occlusion) trial, a randomized clinical trial comparing tenecteplase and nonthrombolytic control in patients with minor stroke symptomatic intracranial occlusion, we investigated sex differences efficacy safety tenecteplase. Methods We compared outcomes after versus control, stratified by sex. also female male treated The primary outcome was “responder” outcome, defined as...
Abstract Many health authorities differentiate hospitalizations in patients infected with SARS-CoV-2 as being “for COVID-19” (due to direct manifestations of infection) versus an “incidental” finding someone admitted for unrelated condition. We conducted a retrospective cohort study all hospitalized via 47 Canadian emergency departments, March 2020-July 2022 determine whether infection are less burden and the healthcare system. Using priori standardized definitions applied hospital discharge...
Objective Greater accessibility to ambulatory services may mitigate emergency department (ED) presentations for lower acuity issues. This study examined ED utilization patterns individuals with psoriatic arthritis (PsA) and ankylosing spondylitis (AS) in a universal access healthcare setting. Methods Linked population-based administrative datasets Alberta, Canada (fiscal years 2008-2017) were assessed yearly visit frequency, timing, triage acuity, most responsible diagnoses, disposition...
Abstract Bleeding complications associated with oral anticoagulant (OAC) frequently lead to emergency department visits and hospitalization. Short-term all-cause mortality after severe bleeding is substantial ranging from approximately 10% for gastrointestinal (the most frequent single site) 50% intracranial bleeding. A protocol multidisciplinary approach needed (i) ensure rapid identification of patients at risk adverse outcomes, (ii) optimize delivery supportive measures, (iii) treat the...
The nucleus must maintain stiffness to preserve its shape and integrity ensure proper function. Defects in nuclear caused from chromatin lamin perturbations produce abnormal shapes common aging, heart disease, cancer. Loss of via protrusions called blebs lead rupture that is well-established cause dysfunction, including DNA damage. However, it remains unknown how increased damage affects stiffness, shape, ruptures, which could create a feedback loop. To determine if alters physical...
Some emergency department (ED) visits by persons with rheumatoid arthritis (RA) may be avoidable. This study aims to describe ED use RA in Alberta, Canada over a 10-year period. Using linked population-based administrative datasets, the annual frequency of visits, timing acuity at presentation assessed (Canadian Triage Acuity Scale (CTAS)), return within 72 h, and final disposition were assessed. Most responsible diagnoses provider categorized. Between 2008 2017, total 48,633 had 416,964...
Abstract BACKGROUND Glioblastoma (GBM) is a heterogenous disease comprised of malignant cell states and an immunosuppressive microenvironment that underlie radiotherapy (RT) resistance. Here we integrate genome wide single in vivo functional genomic screens preclinical models with nuclei spatial transcriptomics human tumors to identify therapeutic vulnerabilities driving GBM radioresistance. MATERIAL AND METHODS Perturb-seq intracranial was performed using (GBM43) or mouse (GL261, SB28)...
Abstract Alterations in cis-regulatory elements, such as hypomethylation of the O-6-methylguanine-DNA methyltransferase (MGMT) promoter and activating mutations within telomerase reverse transcriptase (TERT) promoter, are pervasive drivers glioblastoma (GBM) tumorigenesis that challenging to target. CRISPRoff is an engineered CRISPR/Cas9 system can potently heritably silence elements through DNA methylation. Here, we develop mRNA-based platform target MGMT TERT promoters GBM, establish...
A subset of undifferentiated vertigo cases can be attributed to dangerous central causes such as posterior circulation ischemic stroke (PCIS) or transient attack (TIA). Due a lack validated clinical risk scoring tools, there is currently high heterogeneity in emergency department (ED) neuroimaging practices for patients presenting with vertigo. Therefore, this study assessed the utility head and neck CT angiography (CTA) stratifying ED The primary objective was compare 30-day TIA outcomes...
After radiation or multiple surgeries for oral cancers the patients may develop various degree of xerostomia. They have difficulty in swallowing and speech, also tend to inflammation mucosa, dental caries even trismus. When xerostomia is mild, it can be treated with medication just by frequent hydration water. more severe surgical correction an option, namely using free jejunum colon flap provide lubrication. However, literature there was no comparison between treatment Our hospital receives...
Background: Direct teleconsultations between emergency medical services (EMS) crews and hospital-based stroke neurologists are mandated in the Czech Republic as triage prenotification tool acute patients. The main aim of this study was to analyze efficacy well quality such daily clinical practice. Methods: This is a descriptive analysis EMS paramedic geographically defined region (Moravian-Silesian region) October 2018 December 2018. All were analyzed for length content. Content included...