A5102744543- Glioma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Meningioma and schwannoma management
- Advanced Neuroimaging Techniques and Applications
- Cancer Genomics and Diagnostics
- Medical Malpractice and Liability Issues
- Patient Safety and Medication Errors
- Neurofibromatosis and Schwannoma Cases
- Cardiac, Anesthesia and Surgical Outcomes
- Spinal Dysraphism and Malformations
- Epilepsy research and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Surgical Oncology
- Fetal and Pediatric Neurological Disorders
- DNA Repair Mechanisms
- Advanced MRI Techniques and Applications
- Intracranial Aneurysms: Treatment and Complications
- Neuroblastoma Research and Treatments
- Neurosurgical Procedures and Complications
- History of Medical Practice
- Pituitary Gland Disorders and Treatments
- Cancer therapeutics and mechanisms
- Medical Imaging Techniques and Applications
- Facial Rejuvenation and Surgery Techniques
University of California, San Francisco
1999-2024
Neurological Surgery
1990-2024
University of California Office of the President
2020
University of Washington
1990-1997
Quakers
1996
University of Washington Medical Center
1990-1996
Seattle Children's Hospital
1994
Children's Hospital & Medical Center
1990-1994
Seattle University
1993-1994
Opinion (Norway)
1990
Intraoperative stimulation mapping of subcortical white matter tracts during the resection gliomas has become a valuable surgical adjunct that is used to reduce morbidity associated with tumor removal. The purpose this retrospective analysis was assess and functional outcome method, thus allowing surgeon predict likelihood causing temporary or permanent motor deficit.In study, authors report their experience intraoperative locate pathways in 294 patients who underwent surgery for hemispheric...
✓ Dissecting aneurysms of the intracranial posterior circulation are unusual lesions that affect otherwise healthy young adults, difficult to diagnose and manage, carry a high morbidity mortality rate. Headache in suboccipital-posterior cervical region is most common presenting symptom. The dissection usually occurs between intima or internal elastic lamina media; subadventitial does occur accounts for infrequent finding subarachnoid hemorrhage. A deficit inner layers vessel proposed source...
✓ Epidermoid cysts originating in the paramedian basal cisterns of posterior fossa are congenital lesions that grow to a large size through slow accumulation desquamated epithelium. These between and ultimately displace cranial nerves, vascular structures, brain stem, causing long course progressive neurological deficits. The onset symptoms usually occurs during fourth decade life. easily diagnosed with computerized tomography scans, which characteristically show low-density extra-axial...
✓ Adults and children with low-grade gliomas often present medically refractory epilepsy. Currently, controversy exists regarding the need for intraoperative electrocorticography (ECoG) to identify and, separately, resect seizure foci versus tumor removal alone yield maximum control in this patient population. Forty-five patients intractable epilepsy were retrospectively analyzed respect preoperative frequency duration, number of antiepileptic drugs, ECoG data (single multiple foci),...
✓ A consecutive series of 37 children (17 years old and under) with severe head injury is presented. The data confirm that morbidity mortality are lower in than adults: 51% these young patients had a good recovery or moderate disability at 6 months. rate this (33%) higher some reports, but probably more closely approximates the death from injuries an unselected pediatric population do statistics tertiary care hospitals. There was no significant relationship between age outcome group, mass...
The supplementary motor area (SMA) is a region located within each cerebral hemisphere at the posterior mesial border of frontal lobe adjacent to falx. functional significance this has been somewhat unclear, and information regarding its influence on output largely based evoked responses direct stimulation in primates humans. In series patients with primary metastatic tumors involving dominant SMA, distinct pattern postoperative deficits recovery emerged which emphasizes role critical...
✓ The role of specific neuronal populations in epileptic foci was studied by comparing and nonepileptic cortex removed from patients with low-grade gliomas. Epileptic nearby (within 1 to 2 cm) temporal lobe neocortex identified using electrocorticography. Cortical specimens taken four as were all void tumor infiltration. Somatostatin- γ-aminobutyric acid (GABAergic)-immunoreactive neurons counted. Although there no significant difference the overall cell count, authors found a decrease both...
✓ Gangliogliomas are indolent neoplasms that often associated with long-standing intractable seizures. The seizure-free outcome following ganglioglioma resection alone (or “lesionectomy”) has been generally favorable, ranging in most series from 50% to 65%. Thus, the value of epileptogenic cortex addition tumor regard seizure subject controversy. authors describe a 12 patients frontal or temporal lobe gangliogliomas In these patients, intraoperative electrocorticography was used guide along...
The authors retrospectively reviewed 117 pediatric patients with posterior fossa tumors treated at Children's Hospital and Medical Center, Seattle, Washington, between 1976 1990, in an attempt to determine what perioperative intraoperative factors influenced the need for postoperative shunts. ages of patient population ranged from 4 months 16 years 9 months. evaluated included age diagnosis, duration symptoms, extent hydrocephalus, tumor location, resection, presence external ventricular...
The glioblastoma tumor immune microenvironment (TIME) is an immunosuppressive barrier to therapy that encumbers responses checkpoint inhibition (ICI). Immunosuppressive cytokines, pro-tumor myeloid cells, and exhausted T-cells are hallmarks of the TIME. Here we integrate spatial single-cell analyses patient-matched human samples before after ICI with genetic, immunologic, single-cell, pharmacologic studies in preclinical models reveal interleukin-6 (IL-6) reprograms TIME sensitize mouse...
✓ The authors report the results obtained in 11 patients with tuberous sclerosis (TS) who underwent cortical resection surgery for medically intractable epilepsy. Patients' ages at time of ranged from 3 to 46 years (mean 19.6 years). Preoperative epileptiform electroencephalographic abnormalities were focal spike wave discharges six (55%), multifocal four (36%), and generalized one patient (9%). In groups, all (45%) evaluated by means subdural grid strip electrode recordings, whereas...
Primary cerebral neuroblastoma is a distinct pathological and clinical entity that differs from other primitive neuroectodermal tumors. To characterize the course of this lesion, authors performed retrospective analysis in 11 patients who ranged age 17 months to 26 years. The tumor had no predilection for either sex. Signs symptoms were mostly those associated with increased intracranial pressure. lesions commonly involved parietal occipital lobes. Computerized tomography scans nine showed...
A skull-mounted apparatus is described for use with ultrasound probes 16 mm in diameter (5.0-MHz near-field and 7.5-MHz far-field lesions). The system permits ultrasound-guided stereotaxic biopsy of intracranial lesions through a burr hole awake or anesthetized patients. This has been used 19 patients central nervous 1.5 to cm drainage abscess cavities cysts. time required obtain tissue sample after incision the skin ranged from 25 40 minutes. only complication was delayed hemorrhage patient...
Abstract Current evidence suggest an important role for increased repair of drug‐induced DNA damage as one the major mechanisms involved in tumor cell resistance to cis‐DDP. In this study, we examined capacity and activities three related proteins, namely, polymerases α β, total ligase cells a malignant oligodendroglioma obtained from patient before therapy compared it with those specimen acquired after had failed cis‐DDP therapy. was quantitated extent reactivation...
✓ The authors describe a method for quantitation of the area and volume resection cavity in patients who have undergone surgery brain tumors. Using slide scanner Image 1.27, public domain program Apple Macintosh II computer, computerized tomography scans magnetic resonance images can be digitized analyzed particular region interest, such as tumor on preoperative postresection scans. Phantom were used to analyze accuracy users. User error was estimated at 2%, 4.5%. This methodology is...
✓ A persistent carotid-basilar anastomosis (primitive trigeminal artery), identified by four-vessel vertebral angiography, was shown to be the cause of a cavernous sinus fistula in 51-year-old woman. The fistula, but not primitive artery, on carotid arteriogram. Because flow contribution from posterior circulation, balloon embolization via system failed, and repaired through direct surgical approach. operative technique is described hemodynamic aspects that related this are reviewed.