A5084548340- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Brain Metastases and Treatment
- Neurofibromatosis and Schwannoma Cases
- Head and Neck Surgical Oncology
- Adrenal and Paraganglionic Tumors
- Lung Cancer Research Studies
- Spine and Intervertebral Disc Pathology
- Anesthesia and Pain Management
- Cancer, Hypoxia, and Metabolism
- Spinal Fractures and Fixation Techniques
- Radiomics and Machine Learning in Medical Imaging
- PARP inhibition in cancer therapy
- RNA Research and Splicing
- Chronic Disease Management Strategies
- Spinal Hematomas and Complications
- Prostate Cancer Treatment and Research
- Lung Cancer Treatments and Mutations
- Musculoskeletal pain and rehabilitation
- Trauma and Emergency Care Studies
- Prostate Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Bone health and osteoporosis research
- Injury Epidemiology and Prevention
University of California, San Francisco
2020-2025
Neurological Surgery
2020-2025
City College of San Francisco
2023-2024
Ho Chi Minh City University of Industry and Trade
2024
Industrial University of Ho Chi Minh City
2024
The University of Texas Southwestern Medical Center
2024
Hospital for Sick Children
2023
Westmead Hospital
2023
University of California, Los Angeles
2020-2021
Johns Hopkins University
2020
Study Design. Prospective randomized study to compare the efficacy of facet joint injection with lidocaine and saline in two groups patients low back pain, without clinical criteria that were determined a previous implicate as primary source pain. Objectives. To assess single anesthesia versus placebo (saline injections) determine are predictive significant relief LBP after injection. Summary Background Data. There is no syndrome discriminates between lower pain caused by other structures....
BACKGROUND AND OBJECTIVES: Extent of resection (EOR) is prognostic for meningioma outcomes. DNA methylation profiling can shed light on biological drivers and therapeutic vulnerabilities. The goal this study was to re-evaluate the impact EOR clinical outcomes across groups. METHODS: Patients with sporadic meningiomas who underwent from a multicenter, international cohort were retrospectively reviewed. Gross vs subtotal (GTR STR, respectively) determined based postoperative MRI. Kaplan-Meier...
Extent of resection (EOR) has been consistently identified as prognostic for meningioma outcomes across histology-defined WHO grades. Recent risk stratification systems based on molecular features such DNA methylation profiling shed light biological drivers and therapeutic vulnerabilities, correlate with local freedom from recurrence (LFFR) overall survival (OS). The goal this retrospective, international study was to reevaluate the impact surgical extent these clinical groups. Patients...
The glioblastoma tumor immune microenvironment (TIME) is an immunosuppressive barrier to therapy that encumbers responses checkpoint inhibition (ICI). Immunosuppressive cytokines, pro-tumor myeloid cells, and exhausted T-cells are hallmarks of the TIME. Here we integrate spatial single-cell analyses patient-matched human samples before after ICI with genetic, immunologic, single-cell, pharmacologic studies in preclinical models reveal interleukin-6 (IL-6) reprograms TIME sensitize mouse...
Abstract Inactivation of tumor suppressor Runt-related transcription factor 3 (RUNX3) plays an important role during early tumorigenesis. However, posttranslational modifications (PTM)-based mechanism for the inactivation RUNX3 under hypoxia is still not fully understood. Here, we demonstrate a that G9a, lysine-specific methyltransferase (KMT), modulates through PTM hypoxia. Hypoxia significantly increased G9a protein level and interacted with Runt domain, which led to methylation at K129...
Ommaya reservoir insertion is an elective neurosurgical procedure to deliver repeated intraventricular therapy, but placement can be complicated by malposition of the catheter, clogging, infection or poor postoperative cosmesis. Here, we describe technique used senior author for accurate including preassembly and recessing so that others may consider their practice. Results in a consecutive series 27 placements were reviewed. Catheter tip accuracy, complications surgical times reported....
Abstract Meningeal solitary fibrous tumors (SFT) are rare and have a high frequency of local recurrence distant metastasis. In cohort 126 patients (57 female, 69 male; mean age at surgery 53.0 years) with pathologically confirmed meningeal SFTs extended clinical follow‐up (median 9.9 years; range 15 days–43 years), we performed extensive molecular characterization including genome‐wide DNA methylation profiling ( n = 80) targeted TERT promoter mutation testing 98). Associations were examined...
BACKGROUND AND OBJECTIVE: Patients who undergo gross total resection (GTR) of Central Nervous System World Health Organization (WHO) grade 1 meningioma constitute a “low-risk” group, but some low-risk meningiomas can recur despite reassuring clinical and histological features. In this study, gene expression values in newly diagnosed WHO that had undergone GTR were evaluated for their association with recurrence. METHODS: This was retrospective, international, multicenter cohort study...
Pituitary neuroendocrine tumors (PitNET) that metastasize comprise ~ 0.2% of adenohypophyseal are aggressive and challenging to treat. However, many non-metastatic also aggressive. Herein, we review 21 specimens from 13 patients at UCSF with metastatic PitNETs (CSF or systemic, N = 7 patients), high-grade pituitary neoplasms (HG-PitNEN, 4 and/or sarcomatous transformation (PitNET-ST, 5 patients). We subtyped cases using the World Health Organization (WHO) International Agency for Research on...
Deguelin is a nature-derived chemopreventive drug. Endothelial progenitor cells (EPCs) are bone-marrow (BM)-derived key components to induce new blood vessels in early tumorigenesis and metastasis. Here we determined whether deguelin inhibits EPC function vitro vivo at doses not affecting cancer cell apoptosis. significantly reduced the number of colony forming units BM-derived c-kit+/sca-1+ mononuclear (MNCs), proliferation, migration, adhesion endothelial monolayers, suppressed...
Abstract Background Surgery is the mainstay of treatment for meningioma, most common primary intracranial tumor, but improvements in meningioma risk stratification are needed and current indications postoperative radiotherapy controversial. Recent studies have proposed prognostic classification systems using DNA methylation profiling, copy number variants, sequencing, RNA histology, or integrated models based on multiple combined features. Targeted gene expression profiling has generated...
Meningiomas are the most common primary intracranial tumor, and resection is a mainstay of treatment. It unclear what duration imaging follow-up reasonable for WHO grade I meningiomas undergoing complete resection. This study examined recurrence rates, timing recurrence, risk factors in patients (as defined by both postoperative MRI intraoperative impression) meningiomas.The authors conducted retrospective, single-center examining adult with single meningioma that underwent Uni- multivariate...
Abstract Background While genetic alterations in brain metastases (BMs) have been previously explored, there are limited data examining their association with recurrence after surgical resection. This study aimed to identify within BMs associated CNS surgery across multiple cancer types. Methods A retrospective, single-center was conducted patients who underwent resection of a BM available clinical and gene sequencing available. Local remote were the primary outcomes. Next-generation coding...
Surgical management of meningiomas involving the petroclival junction remains a challenge because nearby critical neurovascular structures.To describe surgical approach selection, outcomes, and factors associated with postoperative complications neurological deficits in series patients undergoing resection region meningiomas.Retrospective review symptomatic meningioma was performed. Logistic regression performed to identify variables new deficits.Sixty-five underwent 54 one-stage 11...
Endothelial progenitor cells (EPCs) are derived from hematopoietic stem cells, and have the ability to differentiate into mature endothelial contribute neovascularization. Glyceollins a type of phytoalexin produced in soybeans under stress conditions. The aim this study is determine effect glyceollin treatment on EPCs during early tumor vasculogenesis.We found that significantly decreased number EPC colony-forming units human cord blood-derived AC133⁺ mouse bone-marrow-derived...
Pain and postoperative nausea vomiting (PONV) are common problems after gynaecologic laparoscopy. Two recent studies have shown that morphine requirements PONV lower when a LMA ProSeal™ is used, rather than an endotracheal tube (ETT), for female patients undergoing breast gynaecological surgery. We conducted patient observer-blinded randomised controlled trial, recruiting non-obese women without gastro-oesophageal reflux laparoscopic Patients received standardised relaxant general...