A5103141794- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Palliative Care and End-of-Life Issues
- Lung Cancer Treatments and Mutations
- Cancer survivorship and care
- Meningioma and schwannoma management
- Cancer Genomics and Diagnostics
- Suicide and Self-Harm Studies
- Radiomics and Machine Learning in Medical Imaging
- Childhood Cancer Survivors' Quality of Life
- Pituitary Gland Disorders and Treatments
- Colorectal Cancer Treatments and Studies
- Religion, Spirituality, and Psychology
- Patient Dignity and Privacy
- Management of metastatic bone disease
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Radiopharmaceutical Chemistry and Applications
- Family Support in Illness
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Bone health and treatments
- Head and Neck Cancer Studies
- Cancer-related cognitive impairment studies
- Psychosomatic Disorders and Their Treatments
- Medical Imaging Techniques and Applications
University of Hong Kong
2017-2025
Chinese University of Hong Kong
2017-2025
Royal Preston Hospital
2024
University of Hong Kong - Shenzhen Hospital
2021-2023
Queen Mary Hospital
2017-2022
Tuen Mun Hospital
2015-2019
Dana-Farber Brigham Cancer Center
2014-2015
Dana-Farber Cancer Institute
2014-2015
Brigham and Women's Hospital
2014-2015
Harvard University
2014
A majority of lung cancer patients are diagnosed at advanced stages. Although there is considerable evidence the benefits aerobic exercise and tai-chi for patients, little known about comparative effectiveness 2 modes in patients.
We hypothesized that radiation-induced lymphopenia could be predicted by the effective dose to circulating immune cells (EDIC) in advanced esophageal squamous cell carcinoma treated with trimodality therapy according Dutch ChemoRadiotherapy for Oesophageal cancer followed Surgery Study (CROSS) trial regimen. To test this hypothesis, we examined effect of EDIC on degree lymphocyte drop (lymphocyte nadir).Patients nonmetastatic a single tertiary center from 2012 2018 were eligible study. All...
Abstract Purpose Alternating electric fields (AEF) therapy in addition to temozolomide chemoradiotherapy (TMZ CRT) is increasingly being recommended as first-line treatment for patients with newly-diagnosed WHO grade 4 astrocytoma. However, few have validated this real-world evidence. Methods Consecutive adult astrocytoma treated adjuvant TMZ CRT across all neuro-oncology centers Hong Kong were reviewed. Identified from a territory-wide prospective glioma registry, propensity-score matching...
// Peter Y.M. Woo 1 , Tai-Chung Lam 2 Jenny K.S. Pu 3 Lai-Fung Li Roland C.Y. Leung 4 Jason M.K. Ho James T.F. Zhung 5 Belinda Wong 6 Timonthy S.K. Chan 7 Herbert H.F. Loong 8 and Ho-Keung Ng 9 Department of Neurosurgery, Kwong Wah Hospital, Hong Kong Clinical Oncology, Ka Shing Faculty Medicine, The University Kong, Queen Mary Pharmacy Medical Therapeutics, Pathology, Chinese Anatomical Cellular Correspondence to: Lam, email: lamtc03@hku.hk Keywords: glioblastoma; BRAF V600E mutation;...
To evaluate the feasibility and potential effects of patient-centred self-administered acupressure for alleviating fatigue co-occurring symptoms among Chinese advanced cancer patients receiving treatment.Thirty who screened positive moderate/severe with insomnia and/or pain were recruited from a hospital in Hong Kong. They randomly assigned (1:1) to receive 4-week intervention or health education. Fatigue (primary outcome) secondary outcomes (sleep quality, pain, fatigue-sleep...
The aim of this study is to address the paucity epidemiological data regarding characteristics, treatment patterns and survival outcomes Chinese glioblastoma patients.This was a population-level Hong Kong adult (>18 years) patients with newly diagnosed histologically confirmed between 2006 2019. age standardized incidence rate (ASIR), patient-, tumor- treatment-related overall (OS) as well its predictors were determined.One thousand ten median follow-up 10.0 months reviewed. ASIR 1.0 per 100...
Abstract Background Surgery is the mainstay of treatment for meningioma, most common primary intracranial tumor, but improvements in meningioma risk stratification are needed and current indications postoperative radiotherapy controversial. Recent studies have proposed prognostic classification systems using DNA methylation profiling, copy number variants, sequencing, RNA histology, or integrated models based on multiple combined features. Targeted gene expression profiling has generated...
The strategy of dual blockade TGF-β and PD-L1 pathways has not been previously tested in platinum-refractory recurrent or metastatic nasopharyngeal cancer (R/M NPC) patients. This study aimed to evaluate the safety efficacy bintrafusp alfa refractory R/M NPC patients.In this single-arm, single-centre phase II clinical trial, 38 histologically confirmed patients were enrolled administered with every 2 weeks. Primary endpoint was objective response rate (ORR) per Response Evaluation Criteria...
<h3>BACKGROUND AND PURPOSE:</h3> Co-occurrence of local anisotropic gradient orientations (COLLAGE) is a recently developed radiomic (computer extracted) feature that captures entropy (measures the degree disorder) in pixel-level edge directions and was previously shown to distinguish predominant cerebral radiation necrosis from recurrent tumor on gadolinium-contrast T1WI. In this work, we sought investigate whether COLLAGE measurements posttreatment T1WI could varying extents classes lesion...
Purposes/objectives: This paper reports the comparative efficacies of integrative body-mind-spirit intervention (I-BMS) and cognitive behavioral therapy (CBT) in patient-caregiver parallel groups for Chinese patients with lung cancer.Design: Randomized controlled trial (RCT).Methods: One hundred fifty-seven dyads no marked functional impairment were randomized into one two interventions eight weekly groups. Assessments conducted at baseline, within one, eight- sixteen-weeks...
Cancer patients had elevated risk of suicidality. However, few researches studied the risk/protective factors suicidal/self-harm behaviors considering competing death. The objective this study is to systematically investigate among Hong Kong cancer as well contributing factors. Patients aged 10 or above who received their first cancer-related hospital admission (2002-2009) were identified and inpatient medical records retrieved. They followed for 365 days Cancer-related information prior...
Tumour mutational burden (TMB) has emerged as a predictive marker for responsiveness to immune checkpoint inhibitors (ICI) in multiple tumour types. It can be calculated from somatic mutations detected whole exome or targeted panel sequencing data. As are unevenly distributed across the cancer genome, clinical implications TMB using different genomic regions not clear. Pan-cancer data of 10,179 samples were collected The Cancer Genome Atlas cohort and 6,831 patients with either ICI non-ICI...
People with serious illness frequently rely on religion/spirituality to cope their diagnosis, potentially positive and negative consequences. Clergy are uniquely positioned help patients consider medical decisions at or near the end of life within a religious/spiritual framework.We aimed examine clergy knowledge end-of-life (EOL) care beliefs about role faith in EOL decision making for illness.Key informant interviews, focus groups, survey.A purposive sample 35 active five U.S. states as...