A5059793697- Palliative Care and End-of-Life Issues
- Cancer survivorship and care
- Pain Management and Opioid Use
- Religion, Spirituality, and Psychology
- Childhood Cancer Survivors' Quality of Life
- Grief, Bereavement, and Mental Health
- Patient-Provider Communication in Healthcare
- Pediatric Pain Management Techniques
- Colorectal Cancer Treatments and Studies
- Family Support in Illness
- Economic and Financial Impacts of Cancer
- Opioid Use Disorder Treatment
- Clinical practice guidelines implementation
- Patient Dignity and Privacy
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Intraperitoneal and Appendiceal Malignancies
- Ethics in medical practice
- Anesthesia and Pain Management
- Neuroblastoma Research and Treatments
- Cultural Competency in Health Care
- Colorectal Cancer Surgical Treatments
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Cancer Treatment and Pharmacology
Dana-Farber Cancer Institute
2016-2025
Harvard University
2013-2025
Brigham and Women's Hospital
2018-2022
National Bureau of Economic Research
2021
CancerCare
2020
Cleveland Clinic
2018
Cornell University
2015
Harvard University Press
2013
To determine how prognostic conversations influence perceptions of life expectancy (LE), distress, and the patient-physician relationship among patients with advanced cancer.This was a multicenter observational study 590 metastatic solid malignancies progressive disease after ≥ one line palliative chemotherapy, undergoing follow-up to death. At baseline, were asked whether their oncologist had disclosed an estimate prognosis. Patients also estimated own LE completed assessments relationship,...
Previous studies report associations between medical utilization at the end-of-life (EoL) and religious coping spiritual support from team. However, influence of clergy communities on EoL outcomes is unclear.To determine whether influences terminally ill patients' care quality life (QoL) near death.A US-based, multisite cohort study 343 patients with advanced cancer enrolled September 2002 through August 2008 followed up (median duration, 116 days) until death. Baseline interviews assessed...
Abstract While BRAF inhibitor combinations with EGFR and/or MEK inhibitors have improved clinical efficacy in V600E colorectal cancer (CRC), response rates remain low and lack durability. Preclinical data suggest that BRAF/MAPK pathway inhibition may augment the tumor immune response. We performed a proof-of-concept single-arm phase 2 trial of combined PD-1, sparatlizumab (PDR001), dabrafenib trametinib 37 patients CRC. The primary end point was overall rate, secondary points were...
PURPOSE Heightened regulations have decreased opioid prescribing across the United States, yet little is known about trends in access among patients dying of cancer. METHODS Among 270,632 Medicare fee-for-service decedents with poor prognosis cancers, we used part D data to examine from 2007 2017 prescription fills and potency (morphine milligram equivalents per day [MMED]) near end-of-life (EOL), defined as 30 days before death or hospice enrollment. We administrative claims evaluate...
To characterize racial and ethnic disparities trends in opioid access urine drug screening (UDS) among patients dying of cancer, to explore potential mechanisms.
BACKGROUND The US opioid epidemic has prompted dramatic changes in public attitudes and regulations governing prescribing. Little is known about the experiences of patients with advanced cancer using opioids context epidemic. METHODS Semistructured interviews 26 were conducted between May 2019 April 2020; their self‐managing chronic pain evaluated. RESULTS Patients consistently described negative impact on ability to self‐manage pain. Negative media coverage personal promoted stigma, fear,...
Black and Hispanic cancer patients experience many worse care quality health outcomes than non-Hispanic White patients, yet less is known about disparities in caregiving responsibilities burden among caregivers.
Spiritual care (SC) is important to the of seriously ill patients. Few studies have examined types SC provided and their perceived impact. This study surveyed patients with advanced cancer (N = 75, response rate [RR] 73%) oncology nurses physicians 339, RR 63%). Frequency impact 8 were assessed. infrequently provided, encouraging or affirming beliefs most common type (20%). history taking chaplaincy referrals comprised 10% 16%, respectively. Most viewed each positively, training predicted...
PURPOSE Symptoms are vital outcomes for cancer clinical trials, observational research, and population-level surveillance. Patient-reported (PROs) valuable monitoring symptoms, yet there many challenges to collecting PROs at scale. We sought develop, test, externally validate a deep learning model extract symptoms from unstructured notes in the electronic health record. METHODS randomly selected 1,225 outpatient progress among patients treated Dana-Farber Cancer Institute between January...
Abstract Objectives Well-differentiated neuroendocrine tumors (NET) are highly vascular characterized by their expression of endothelial growth factor (VEGF). This trial investigated the activity ramucirumab, a monoclonal antibody that targets VEGF receptor-2 (VEGFR-2) and inhibits VEGF, in combination with somatostatin analog therapy patients (pts) advanced extra-pancreatic NET. Methods We conducted single-arm phase II enrolling pts advanced, progressive Patients were treated ramucirumab 8...
Background Despite the biopsychosocial underpinnings of chronic noncancer pain, relatively little is known about contribution psychosocial factors to cancer pain. The authors aimed characterize associations between and pain opioid use among individuals with cancer. Methods conducted a retrospective, cross‐sectional study 700 patients seeking treatment at an academic tertiary clinic. Patients completed demographic questionnaires validated measures. Multivariable, hierarchical linear logistic...
Pain is common among people with advanced cancer. While opioids provide significant relief, incorporating psycho-behavioral treatments may improve pain outcomes. We examined patients' experiences self-management and how their of chronic, cancer-related be complemented by behavioral mobile health (mHealth) interventions.
ContextAlthough many studies have addressed the integration of a religion and/or spirituality curriculum into medical school training, few describe process development based on qualitative data from students and faculty.ObjectivesThe aim this study is to explore perspectives chaplaincy trainees regarding facilitate reflection moral spiritual dimensions caring for critically ill train in self-care practices that promote professionalism.MethodsResearch staff conducted semiscripted one-on-one...
Abstract Background Goblet cell carcinoid (GCC) tumors of the appendix are a rare malignancy. We aim to examine overall survival per stage and relationship between different treatment modalities outcomes for patients with GCC appendix. Methods identified from National Cancer Database. The main outcome was patient cox proportional hazard models were used ascertain predictors survival. Results There 2552 identified. median age diagnosis 57 (interquartile range: 49‐65) 52.3% female. 5‐year...