A5030417585- Lung Cancer Treatments and Mutations
- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer Research and Treatments
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Retinoids in leukemia and cellular processes
- Tracheal and airway disorders
- Colorectal Cancer Treatments and Studies
- Viral-associated cancers and disorders
- COVID-19 Clinical Research Studies
- Neuropeptides and Animal Physiology
- Cancer, Hypoxia, and Metabolism
- Amino Acid Enzymes and Metabolism
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lymphoma Diagnosis and Treatment
- Respiratory viral infections research
- RNA modifications and cancer
- Cancer therapeutics and mechanisms
- Superconducting Materials and Applications
- Cancer Genomics and Diagnostics
- Salivary Gland Tumors Diagnosis and Treatment
University of Hong Kong
2016-2025
Queen Mary Hospital
2016-2025
Prometheus (United States)
2023-2025
Prince of Wales Hospital
2025
Chinese University of Hong Kong
2004-2025
Nanyang Technological University
2024
Oregon State University
2022-2023
Nanjing University
2022
The University of Western Australia
2013-2020
York District Hospital
2020
Standard cytotoxic treatments for neuroendocrine tumours have been associated with limited activity and remarkable toxicity. A phase II study was designed to evaluate the efficacy, safety pharmacodynamics of temsirolimus in patients advanced carcinoma (NEC). Thirty-seven progressive NEC received intravenous weekly doses 25 mg temsirolimus. Patients were evaluated tumour response, time progression (TTP), overall survival (OS) adverse events (AE). Twenty-two archival specimens, as well 13...
To evaluate lung abnormalities on serial thin-section computed tomographic (CT) scans in patients with severe acute respiratory syndrome (SARS) during and convalescent periods.Serial CT 30 (17 men, aged 42.5 years +/- 12.2 [SD]) SARS were reviewed by two radiologists together for predominant patterns of abnormalities: ground-glass opacities, opacities superimposed linear consolidation, reticular pattern, mixed pattern (consolidation, pattern). Scans classified according to duration weeks...
The increased susceptibility of the elderly to lower respiratory tract infection cannot be fully explained. Although mucociliary clearance, which is affected by ciliary beating and ultrastructure, plays a crucial role in defense airways against inhaled microbes, little known effects aging on these parameters. We studied nasal clearance (NMCC) time, beat frequency, ultrastructure cilia cohort healthy volunteers (age range 11 90 yr). Ciliary frequency ciliated epithelial cells was obtained via...
Expression of erbB2 and/or epidermal growth factor receptor (EGFR) is associated with biologic aggressiveness and poor prognosis in malignant salivary gland tumors (MSGTs). This phase II study was conducted to determine the antitumor activity lapatinib, a dual inhibitor EGFR tyrosine kinase activity, MSGTs.Patients progressive, recurrent, or metastatic adenoid cystic carcinoma (ACC) immunohistochemically expressing at least 1+ 2+ were treated lapatinib 1,500 mg daily, two-stage cohort....
The treatment of atypical pneumonia, subsequently termed severe acute respiratory syndrome (SARS), is controversial, and the efficacy corticosteroid therapy unknown. We have evaluated clinical radiographic outcomes 72 patients with probable SARS (median age 37 years, 30 M), who received ribavirin different steroid regimens in two regional hospitals. Chest radiographs were scored according to percentage lung field involved. Seventeen initially pulse (PS) (methylprednisolone ⩾ 500 mg/day) 55...
Computer image analysis techniques have decreased effects of observer biases, and increased the sensitivity throughput immunohistochemistry (IHC) as a tissue-based procedure for evaluation diseases.We adapted Cyan/Magenta/Yellow/Key (CMYK) model automated computer to quantify IHC stains in hematoxylin counterstained histological sections.The spectral characteristics chromogens AEC, DAB NovaRed well counterstain were first determined using CMYK, Red/Green/Blue (RGB), normalized RGB...
Erlotinib (Tarceva™, OSI-774), a potent epidermal growth factor receptor tyrosine kinase inhibitor (EGFR), was evaluated in phase II study to assess its activity patients with metastatic colorectal cancer. In all, 38 cancer were treated erlotinib at continuous daily oral dose of 150 mg. Radiological evaluation carried out every 8 weeks and tumour biopsies performed before treatment on day 8. Of 31 evaluable patients, 19 (61%) had progressive disease 12 (39%) stable (s.d.). The median time...
IntroductionThe phase III randomized PROFILE 1014 study demonstrated superiority of crizotinib to first-line chemotherapy in prolonging progression-free survival (PFS) previously untreated patients with ALK receptor tyrosine kinase gene (ALK)-positive advanced nonsquamous NSCLC. This result was consistent that the smaller subset East Asian 1014. The subsequent reported here prospectively evaluated a larger patient population.MethodsIn this open-label (PROFILE 1029), were 1:1 receive orally...
In hepatocellular carcinoma (HCC) patients with extrahepatic metastasis, the lung is most frequent site of metastasis. However, how microenvironment favors disseminated cells remains unclear. Here, it found that nidogen 1 (NID1) in metastatic HCC cell-derived extracellular vesicles (EVs) promotes pre-metastatic niche formation by enhancing angiogenesis and pulmonary endothelial permeability to facilitate colonization tumor EV-NID1 also activates fibroblasts, which secrete necrosis factor...
Sleep disturbances prevalent among patients with advanced lung cancer can aggravate physical and psychological symptoms, contributing to decreased quality of life survival.
Pseudomonas aeruginosa is an important pathogen in patients with chronic respiratory diseases. It can colonize the airway and could have prognostic value bronchiectasis cystic fibrosis. Its role obstructive pulmonary disease (COPD) less well defined. A prospective study was conducted Hong Kong to investigate possible association between colonization acute exacerbation of COPD (AECOPD) risks. Among 327 Chinese included, 33 (10.1%) had colonization. Patients or without similar background...
Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are important in tumor development progression. MMP expression has been correlated with advanced clinical stage poor survival some tumors, but data for small-cell lung cancer (SCLC) lacking. The aim of this study was to assess the MMPs TIMPs SCLC evaluate importance relative standard prognostic factors.Expression MMP-1, -2, -3, -9, -11, -13, -14 TIMP-1, -4 evaluated by immunohistochemistry (IHC). In situ hybridization used...
To elucidate low-dimensional effects on thermoelectric materials, bismuth telluride film and nanowires array were fabricated by potentiostatically electrodeposition. Both materials are slightly Te-rich, n-type Bi2Te3, exhibiting preferred orientation in rhombohedral strcture. For both the Seebeck coefficient S ≈ −70 μV/K at 300 K decreases linearly with decreasing temperature, showing a diffusive nature of current flow. The temperature dependence resistivity (=1/σ) obtained from data...
Abstract Background and objective The A sthma I nsight M anagement ( AIM ) survey was conducted in N orth merica, E urope, the sia‐ P acific region L atin merica to characterize patients’ insights, attitudes perceptions about their asthma its treatment. We report findings from survey. Methods Asthma patients (≥12 years) ustralia, C hina, H ong K ong, ndia, alaysia, S ingapore, outh orea, T aiwan hailand were surveyed. Patients answered 53 questions exploring general health,...