A5050218301- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Head and Neck Cancer Studies
- Lung Cancer Research Studies
- Radiopharmaceutical Chemistry and Applications
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Management of metastatic bone disease
- Medical Imaging Techniques and Applications
- Lung Cancer Treatments and Mutations
- Pituitary Gland Disorders and Treatments
- Cancer Genomics and Diagnostics
- Neurofibromatosis and Schwannoma Cases
- Neuroblastoma Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Cancer-related cognitive impairment studies
- Radiation Dose and Imaging
- Radiation Therapy and Dosimetry
- Palliative Care and End-of-Life Issues
- Nanoplatforms for cancer theranostics
- Pancreatic and Hepatic Oncology Research
- Systemic Sclerosis and Related Diseases
- Anesthesia and Sedative Agents
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2020-2025
The Ohio State University Wexner Medical Center
2021-2025
University Hospitals Seidman Cancer Center
2024-2025
Case Western Reserve University
2024-2025
The Ohio State University
2021-2024
Digital Health Cooperative Research Centre
2022
Digital China Health (China)
2022
University of Miami
2017-2020
University of Arkansas at Fayetteville
2014
BackgroundCurrent standard of care treatment for patients with ≥15 brain metastases(BM) is whole radiation therapy(WBRT), despite poor neurocognitive outcomes. We analyzed our institutional experience treating these stereotactic radiosurgery(SRS), the aim evaluating safety, cognitive outcomes, and survival metrics.MethodsPatients who received SRS BMs in 1-5 fractions from 2014-2022 were included. Cognitive outcomes objectively evaluated using serial Patient-Reported Outcome Measurement...
There is marked variability in treatment fields for glioblastoma. We performed a retrospective study comparing outcomes of patients treated according to MD Anderson Cancer Center (MDACC) or Radiation Therapy Oncology Group (RTOG) guidelines and identified differences treatment-related toxicity. Adult with glioblastoma surgery adjuvant radiation were included this study. Primary local control, progression-free survival (PFS), overall (OS), radiation-related PFS OS estimated using the...
Abstract Background Our previous clinical investigation suggested that hypofractionated stereotactic re-irradiation (HFSRT) and PD-1 blockade may act synergistically to enhance the immune response against glioma. This subsequent trial investigated dual of CTLA4 in combination with HFSRT bevacizumab. Methods phase I study enrolled eligible patients bevacizumab-naïve recurrent glioblastoma or anaplastic astrocytoma. Participants received nivolumab, ipilimumab bevacizumab concurrently (3000 cGy...
Preoperative stereotactic radiosurgery (SRS) has been demonstrated as a feasible alternative to postoperative SRS for resectable brain metastases (BMs) with potential benefits in adverse radiation effects (AREs) and meningeal disease (MD). However, mature large-cohort multicenter data are lacking.
There are limited data regarding outcomes for patients with gastrointestinal (GI) primaries and brain metastases treated stereotactic radiosurgery (SRS).To examine clinical after SRS from GI evaluate potential prognostic factors.The International Radiosurgery Research Foundation centers were queried managed SRS. Primary local control (LC) overall survival (OS). Kaplan-Meier analysis was used univariate (UVA) of factors. Factors significant on UVA evaluated a Cox multivariate proportional...
The standard treatment for patients with large brain metastases and limited intracranial disease is surgical resection post-operative stereotactic radiosurgery (SRS). However, SRS still has elevated rates of local failure (LF) complicated by radiation necrosis (RN), meningeal (MD). Pre-operative may reduce the risk RN MD, while fractionated therapy improve control through delivering a higher biological effective dose. We hypothesize that pre-operative (FSRT) will have less toxicity compared...
BACKGROUND AND OBJECTIVE: Patients who undergo gross total resection (GTR) of Central Nervous System World Health Organization (WHO) grade 1 meningioma constitute a “low-risk” group, but some low-risk meningiomas can recur despite reassuring clinical and histological features. In this study, gene expression values in newly diagnosed WHO that had undergone GTR were evaluated for their association with recurrence. METHODS: This was retrospective, international, multicenter cohort study...
Abstract Background Global incidence for brain tumors varies substantially without explanation. Studies correlating radon exposure and are inconclusive. Particulate pollution has been linked to increased tumor incidence. Particulates may disrupt the blood-brain barrier allowing intracranial oncogenic radon. We investigated relationship between residential radon, particulate pollution, in United States (US). Methods County-level median testing results annual air quality index values were...
Abstract Background Surgery is the mainstay of treatment for meningioma, most common primary intracranial tumor, but improvements in meningioma risk stratification are needed and current indications postoperative radiotherapy controversial. Recent studies have proposed prognostic classification systems using DNA methylation profiling, copy number variants, sequencing, RNA histology, or integrated models based on multiple combined features. Targeted gene expression profiling has generated...
Objectives In this study, we aim to determine the frequency of adherence National Comprehensive Cancer Network follow‐up guidelines in a population head and neck cancer patients who received curative treatment. We will also assess impact race, ethnicity, socioeconomic status, treatment setting on utilization care. Methods This study included with biopsy‐proven, nonmetastatic oropharyngeal or laryngeal treated radiotherapy between January 1, 2014, June 30, 2016, at safety‐net hospital...
Background The standard of care for elderly or frail patients with glioblastoma (GBM) is 40 Gy in 15 fractions radiotherapy. However, this regimen has a lower biological effective dose (BED) compared the Stupp 60 30 fractions. It hypothesized that accelerated hypofractionated radiation 52.5 (BED equivalent to Stupp) safe and efficacious. Methods Elderly GBM treated were pooled from 3 phase 1/2 studies prospective observational study. Overall survival (OS) progression‐free (PFS) defined time...
Objective To examine the impact of treatment setting and demographic factors on oropharyngeal laryngeal cancer time to initiation (TTI). Study Design Retrospective case series. Setting Safety net hospital adjacent private academic hospital. Subjects Methods Demographic, staging, details were retrospectively collected for 239 patients treated from January 1, 2014, June 30, 2016. TTI was defined as days between diagnostic biopsy curative (defined first day radiotherapy [RT], surgery, or...