A5030668094- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Management of metastatic bone disease
- Advanced Radiotherapy Techniques
- Lung Cancer Research Studies
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Neuroblastoma Research and Treatments
- Head and Neck Cancer Studies
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Effects of Radiation Exposure
- Breast Cancer Treatment Studies
- Renal cell carcinoma treatment
- Neurofibromatosis and Schwannoma Cases
- Cancer Genomics and Diagnostics
- Pharmacological Effects of Medicinal Plants
- Cancer-related molecular mechanisms research
- Medical Imaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Viral-associated cancers and disorders
- CNS Lymphoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
The Ohio State University Wexner Medical Center
2022-2025
The Ohio State University
2023-2025
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2022-2024
The Radiosurgery Society
2024
University of Virginia
2024
St. Mary's Medical Center
2024
Indian Institute of Technology Dhanbad
2023
The University of Texas MD Anderson Cancer Center
2020-2023
Digital Health Cooperative Research Centre
2022
Digital China Health (China)
2022
BackgroundCurrent standard of care treatment for patients with ≥15 brain metastases(BM) is whole radiation therapy(WBRT), despite poor neurocognitive outcomes. We analyzed our institutional experience treating these stereotactic radiosurgery(SRS), the aim evaluating safety, cognitive outcomes, and survival metrics.MethodsPatients who received SRS BMs in 1-5 fractions from 2014-2022 were included. Cognitive outcomes objectively evaluated using serial Patient-Reported Outcome Measurement...
Brainstem toxicity after radiation therapy (RT) is a devastating complication and particular concern with proton (PBT). We investigated the incidence clinical correlates of brainstem injury in pediatric brain tumors treated PBT.All patients <21 years PBT at our institution from 2007-2019, Dmean >30 Gy and/or Dmax >50.4 were included. Symptomatic (SBI) was defined as any new or progressive cranial neuropathy, ataxia, motor weakness corresponding radiographic abnormality within brainstem.A...
Repeat stereotactic radiosurgery (SRS) for persistent cerebral arteriovenous malformation (AVM) has generally favorable patient outcomes. However, reporting studies are limited by small numbers and single-institution biases. The purpose of this study was to provide the combined experience multiple centers, in an effort fully define role repeat SRS patients with malformation.This multicenter, retrospective cohort included treated repeat, single-fraction between 1987 2022. Follow-up began at...
Metastatic renal cell carcinoma (mRCC) is a heterogenous disease with variable clinical course. While therapies for treatment of this condition have progressed, they are not without toxicity. In some patients, active surveillance (AS) increasingly considered to delay its This article seeks review the literature and discuss management metastatic carcinoma, specifically regarding upfront AS, role radiation therapy in delaying systemic therapy, after initial therapy. Median time on AS prior...
Trastuzumab-deruxtecan (T-DXd) has demonstrated intracranial efficacy; however, safety and efficacy data remains limited with stereotactic radiosurgery (SRS). A multi-institutional review was performed HER2+ or HER2-low metastatic breast cancer treated T-DXd SRS for active brain metastases. We identified 215 lesions over 48 courses in 34 patients. Median follow up from initiation 13.9 months. The cumulative incidence of symptomatic radiation necrosis at 24 months per lesion 2.1% patient 11%....
The standard treatment for patients with large brain metastases and limited intracranial disease is surgical resection post-operative stereotactic radiosurgery (SRS). However, SRS still has elevated rates of local failure (LF) complicated by radiation necrosis (RN), meningeal (MD). Pre-operative may reduce the risk RN MD, while fractionated therapy improve control through delivering a higher biological effective dose. We hypothesize that pre-operative (FSRT) will have less toxicity compared...
Head and Neck Squamous Cell Carcinoma (HNSCC) comprises a diverse group of tumors with variable treatment response prognosis. The tumor microenvironment (TME), which includes microbiome immune cells, can impact outcomes. Here, we sought to relate the presence specific microbes, gene expression, infiltration using transcriptomics from Cancer Genome Atlas (TCGA) associate these overall survival (OS). RNA sequencing (RNAseq) HNSCC in TCGA was processed through exogenous sequences cells (exotic)...