A5020788596- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Radical Photochemical Reactions
- Catalytic C–H Functionalization Methods
- Meningioma and schwannoma management
- Sulfur-Based Synthesis Techniques
- Neuroblastoma Research and Treatments
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Management of metastatic bone disease
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Radiopharmaceutical Chemistry and Applications
- Pituitary Gland Disorders and Treatments
- Fluorine in Organic Chemistry
- Sarcoma Diagnosis and Treatment
- Lung Cancer Research Studies
- Medical Imaging Techniques and Applications
- Synthesis of Indole Derivatives
- Synthesis and Characterization of Pyrroles
- Oxidative Organic Chemistry Reactions
- Adrenal and Paraganglionic Tumors
- Chromium effects and bioremediation
- Cyclopropane Reaction Mechanisms
- Testicular diseases and treatments
The Ohio State University
2021-2025
Stanford University
2025
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2021-2024
The Ohio State University Wexner Medical Center
2021-2024
The University of Texas MD Anderson Cancer Center
2022-2023
University of Miami
2023
Na Homolce Hospital
2023
University School
2022
Wake Forest University
2022
University of Pennsylvania
2016-2019
A photoredox-catalyzed C–H functionalization of heteroarenes using a variety primary, secondary, and tertiary alkyltrifluoroborates is reported.
A Ni/photoredox dual catalytic cross-coupling is disclosed in which a diverse range of (hetero)aryl bromides are used as electrophiles, with 1,4-dihydropyridines serving precursors to Csp3-centered alkyl radical coupling partners. The reported method characterized by its extremely mild reaction conditions, enabling access underexplored cores.
Under oxidative conditions, 1,4-dihydropyridines (DHPs) undergo a homolytic cleavage, forming exclusively Csp3-centered radical that can engage in the C-H alkylation of heterocyclic bases and 1,4-quinones. DHPs are readily prepared from aldehydes, considering aldehydes normally require harsh reaction conditions to take part such transformations, with mixtures alkylated acylated products often being obtained, this net decarbonylative approach becomes particularly useful. The present method...
The incorporation of C-glycosides in drug design has become a routine practice for medicinal chemists. These naturally occurring building blocks exhibit attractive pharmaceutical profiles, and have an important target synthetic efforts recent decades. Described herein is practical, scalable, versatile route the synthesis non-anomeric unexploited C-acyl glycosides through Ni/photoredox dual catalytic system. By utilizing organic photocatalyst, range glycosyl-based radicals are generated...
The development of synthetic tools to introduce saccharide derivatives into functionally complex molecules is great interest, particularly in the field drug discovery. Herein, we report a new route toward highly functionalized, arylated saccharides, which involves nickel-catalyzed cross-coupling photoredox-generated saccharyl radicals with range aryl- and heteroaryl bromides, triggered by an organic photocatalyst. In contrast existing methods, mild reaction conditions achieve arylation...
Abstract A regioselective, nickel‐catalyzed photoredox allylation of secondary, benzyl, and α‐alkoxy radical precursors is disclosed. Through this manifold, a variety linear allylic alcohols allylated monosaccharides are accessible in high yields under mild reaction conditions. Quantum mechanical calculations [DFT DLPNO‐CCSD(T)] support the mechanistic hypothesis Ni 0 to II oxidative addition pathway followed by inner‐sphere allylation.
Heteroarylation via C–H functionalization has been synthetically challenging, but such transformations represent an atom-economical and highly convergent route toward complex molecules. Reported herein is a photoredox-catalyzed coupling between 2-trifluoroborato-4-chromanones various heteroarenes through Minisci pathway. Mesitylacridinium perchlorate, organic photocatalyst, proved to be better photocatalyst than transition-metal counterparts for transformations. To highlight the utility of...
Photoredox-mediated radical/polar crossover (RPC) processes offer new avenues for the synthesis of cyclic molecules. This process has been realized construction medium-sized saturated nitrogen heterocycles. Photocatalytically generated alkyl radicals possessing pendant leaving groups engage imines in C–C bond formation, and subsequent reduction intermediate nitrogen-centered radical triggers anionic ring closure. With aid visible light irradiation, substituted pyrrolidines, piperidines,...
OBJECTIVE Stereotactic radiosurgery (SRS) is used for the treatment of residual/recurrent nonfunctional pituitary adenoma (NFPA). The aim this study was to evaluate factors related long-term tumor control and delayed endocrinopathies following SRS. METHODS This retrospective, multicenter included patients with recurrent/residual NFPA treated single-fraction SRS; they were then divided into two arms. first arm at least 5 years radiographic follow-up all local progression. second...
Utilizing photoredox/nickel dual catalysis, diverse flavanones have been synthesized by coupling novel 2-trifluoroboratochromanone building blocks with aryl and heteroaryl bromide partners. The newly reported trifluoroboratochromanones can be easily accessed from the corresponding chromones on multigram scale. This represents a general route for accessing natural unnatural that were previously formed through synthetically more restrictive ring closure chalcone precursors.
Abstract The development of synthetic tools to introduce saccharide derivatives into functionally complex molecules is great interest, particularly in the field drug discovery. Herein, we report a new route toward highly functionalized, arylated saccharides, which involves nickel‐catalyzed cross‐coupling photoredox‐generated saccharyl radicals with range aryl‐ and heteroaryl bromides, triggered by an organic photocatalyst. In contrast existing methods, mild reaction conditions achieve...
Minisci-type alkylation of electron-deficient heteroarenes has been a pivotal technique for medicinal chemists in the synthesis drug-like molecules. However, such transformations usually require harsh conditions (e.g., strong acids, stoichiometric amount oxidants, elevated temperatures, etc.). Herein, by utilizing photoredox catalysis, highly-selective method using heteroaryl sulfones developed that can be carried out under acid-free and redox-neutral conditions. Because these mild...
Preoperative stereotactic radiosurgery (SRS) has been demonstrated as a feasible alternative to postoperative SRS for resectable brain metastases (BMs) with potential benefits in adverse radiation effects (AREs) and meningeal disease (MD). However, mature large-cohort multicenter data are lacking.
Abstract The incorporation of C ‐glycosides in drug design has become a routine practice for medicinal chemists. These naturally occurring building blocks exhibit attractive pharmaceutical profiles, and have an important target synthetic efforts recent decades. Described herein is practical, scalable, versatile route the synthesis non‐anomeric unexploited ‐acyl glycosides through Ni/photoredox dual catalytic system. By utilizing organic photocatalyst, range glycosyl‐based radicals are...
A radical-mediated functionalization of allyl alcohol derived partners with a variety alkyl 1,4-dihydropyridines via photoredox/nickel dual catalysis is described. This transformation transpires high linear and E-selectivity, avoiding the requirement harsh conditions (e.g., strong base, elevated temperature). Additionally, using aryl sulfinate salts as radical precursors, sulfones can also be obtained. Kinetic isotope effect experiments implicated oxidative addition nickel catalyst to...
Herein, the introduction of oxa- and azabenzonorbornadienes into photoredox/nickel dual catalysis in a regioselective diastereoselective transformation is disclosed. The inherent advantages this catalytic system allow use alkyl motifs forming exclusively cis-1,2-dihydro-1-naphthyl alcohol backbones using readily accessible 4-alkyl-1,4-dihydropyridines (DHPs). Whereas previous studies have emphasized nucleophilic organometallic coupling partners, protocol grants access to rather unexplored...
Synovial sarcoma (SS) is a rare, aggressive soft tissue malignancy that divided into biphasic and monophasic histologic subtypes. In addition to surgical resection, radiation therapy (RT) improves local control in patients at higher risk of recurrence. This study aimed investigate the impact subtype on response survival outcomes treated with RT as part definitive management. We retrospectively identified SS resection from 1997 2020 Stanford Medical Center. assessed association between...
There is marked variability in treatment fields for glioblastoma. We performed a retrospective study comparing outcomes of patients treated according to MD Anderson Cancer Center (MDACC) or Radiation Therapy Oncology Group (RTOG) guidelines and identified differences treatment-related toxicity. Adult with glioblastoma surgery adjuvant radiation were included this study. Primary local control, progression-free survival (PFS), overall (OS), radiation-related PFS OS estimated using the...
Abstract A regioselective, nickel‐catalyzed photoredox allylation of secondary, benzyl, and α‐alkoxy radical precursors is disclosed. Through this manifold, a variety linear allylic alcohols allylated monosaccharides are accessible in high yields under mild reaction conditions. Quantum mechanical calculations [DFT DLPNO‐CCSD(T)] support the mechanistic hypothesis Ni 0 to II oxidative addition pathway followed by inner‐sphere allylation.