A5102000578- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Advancements in Battery Materials
- Advanced Battery Materials and Technologies
- Radical Photochemical Reactions
- Advanced Fluorescence Microscopy Techniques
- Catalytic C–H Functionalization Methods
- Advanced Battery Technologies Research
- Sulfur-Based Synthesis Techniques
- Crystallography and molecular interactions
- Photosynthetic Processes and Mechanisms
- Mitochondrial Function and Pathology
- Semiconductor materials and devices
- Advanced Electron Microscopy Techniques and Applications
- Asymmetric Hydrogenation and Catalysis
- Crystal structures of chemical compounds
- Luminescence and Fluorescent Materials
- Silicon Nanostructures and Photoluminescence
- Photoreceptor and optogenetics research
- ATP Synthase and ATPases Research
- Transition Metal Oxide Nanomaterials
- Nanowire Synthesis and Applications
- Catalytic Cross-Coupling Reactions
- Phenothiazines and Benzothiazines Synthesis and Activities
- Solar Energy Systems and Technologies
University of California, Berkeley
2021-2023
Shanghai University of Electric Power
2019-2022
Guilin University of Technology
2015-2020
University of Pennsylvania
2017-2020
Philadelphia University
2019-2020
California University of Pennsylvania
2019-2020
South China University of Technology
2015-2019
Shanghai Jiao Tong University
2016-2018
University of Shanghai for Science and Technology
2017
Washington University in St. Louis
2016
Abstract The inner mitochondrial membrane (IMM) generates power to drive cell function, and its dynamics control health cellular homeostasis. Here, we describe the cell-permeant, lipid-like small molecule MAO-N 3 use it assemble high-density environmentally sensitive (HIDE) probes that selectively label image IMM in live cells multiple states. pairs with strain-promoted azide–alkyne click chemistry-reactive fluorophores support HIDE imaging using confocal, structured illumination,...
Herein we report an atom- and step-economic aromatic cyanoalkylation reaction that employs nitriles as building blocks proceeds through Csp2–H Csp3–H bond activation steps mediated by NiIII. In addition to cyanomethylation with MeCN, regioselective α-cyanoalkylation was observed various nitrile substrates generate secondary tertiary nitriles. Importantly, the best of our knowledge these are first examples C–H reactions occurring at a NiIII center, which may exhibit different reactivity...
New bright, photostable, emission-orthogonal fluorophores that blink without toxic additives are needed to enable multicolor, live-cell, single-molecule localization microscopy (SMLM). Here we report the design, synthesis, and biological evaluation of Yale676sb, a near-IR-emitting fluorophore achieves these goals in context an exceptional quantum yield (0.59). When used alongside HMSiR, Yale676sb enables simultaneous, two-color SMLM two intracellular organelles (ER + mitochondria) with only...
A nickel/photoredox, dual-catalyzed amidation reaction between alkylsilicate reagents and alkyl/aryl isocyanates is reported. In contrast to the previously reported reductive coupling process, this protocol characterized by mild conditions absence of a stoichiometric reductant. mechanistic hypothesis involving nickel-isocyanate adduct proposed based on literature precedent further validation experimental results.
A series of water soluble octa-functionalized POSSs were facilely synthesized via thiol-ene and Menschutkin click chemistry. Among them, octa-alkynyl POSS further reacted with azide-terminal alkyl long chains, resulting in a well-defined, amphiphilic octopus-like POSS. For the first time it was used for host-guest encapsulation exhibited an ultrahigh loading capability.
Minisci-type alkylation of electron-deficient heteroarenes has been a pivotal technique for medicinal chemists in the synthesis drug-like molecules. However, such transformations usually require harsh conditions (e.g., strong acids, stoichiometric amount oxidants, elevated temperatures, etc.). Herein, by utilizing photoredox catalysis, highly-selective method using heteroaryl sulfones developed that can be carried out under acid-free and redox-neutral conditions. Because these mild...
The selective 1,2-aminoacylation of olefins provides opportunities for the rapid construction nitrogen-containing molecules.
Achieving uniform Li deposition is vital for the construction of a safe but also efficient Li-metal anode batteries (LMBs). Herein, facile coating strategy used forming an ultra-thin aramid nanofiber (ANF) membrane, with network structure, on (ANF-Li) as artificial layer inhibiting dendrite's growth. The results show that under ultra-high current density 50 mA cm-2 , ANF-Li|ANF-Li symmetric cells can be kept stably cycled period exceeding 300 h. ANF-Li|LiFePO4 full exhibit high-capacity...
A novel hierarchical mesoporous nitrogen-rich carbon nanospheres comprising one-dimensional (1D) bamboo-like nanotubes encapsulating Fe<sub>3</sub>O<sub>4</sub> nanoparticles synthesized are used as a high-efficiency host for lithium–sulfur batteries.
A radical-mediated functionalization of allyl alcohol derived partners with a variety alkyl 1,4-dihydropyridines via photoredox/nickel dual catalysis is described. This transformation transpires high linear and E-selectivity, avoiding the requirement harsh conditions (e.g., strong base, elevated temperature). Additionally, using aryl sulfinate salts as radical precursors, sulfones can also be obtained. Kinetic isotope effect experiments implicated oxidative addition nickel catalyst to...
Abstract Proteins and polypeptides containing extended backbone monomers embody highly desirable structures functions, but they cannot yet be biosynthesized in cells. There are two challenges at work. First is the ribosome, whose ability to promote rapid bond-forming reactions from anything other than an α-amino acid or α-hydroxy unknown. The second challenge absence of orthogonal enzymes that acylate tRNA with monomers. Here we describe a general approach programmed cellular synthesis...
Ligand effect studies on (<sup>R</sup>N3C)Ni<sup>III</sup>L<sub>2</sub> complexes reveal aerobically-induced aromatic cyanation with <italic>t</italic>BuNC at room temperature for the (<sup>Np</sup>N3C)Ni system.
Lysosomes have long been known for their acidic lumens and efficient degradation of cellular byproducts. In recent years, it has become clear that function is far more sophisticated, involving multiple cell signaling pathways interactions with other organelles. Unfortunately, interior, fast dynamics, small size make lysosomes difficult to image fluorescence microscopy. Here we report a far-red molecule, HMSiR680-Me, fluoresces only under conditions, causing selective labeling organelles in...
In the field of high-density energy storage, lithium–sulfur (Li–S) batteries have attracted more and attention because their high specific capacity affordable cost. However, actual implementation is hindered by dissolution polysulfides severe safety concerns caused flammable electrolytes. Herein, we report preparation an interlayer that can effectively suppress polysulfide shuttling increase working temperature range. this work, polyamide nanofibers (ANFs) are used as substrate material to...
A facile total synthesis of three members the bisabolane sesquiterpene family, namely (±)-curcumene, (±)-xanthorrhizol and (±)-curcuhydroquinone had been achieved in high overall yield. The used bromobenzene derivatives as starting materials. halogen-lithium exchange followed by addition isoprenylacetone reduction obtained carbinols are key steps synthetic pathway. This approach provides a new route to sesquiterpenes.