A5048414027- Immune Response and Inflammation
- PARP inhibition in cancer therapy
- Cardiac Imaging and Diagnostics
- Immune cells in cancer
- Pituitary Gland Disorders and Treatments
- Heat shock proteins research
- Pancreatitis Pathology and Treatment
- Medical Imaging Techniques and Applications
- Liver Disease and Transplantation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Glioma Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Liver Disease Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Protease and Inhibitor Mechanisms
- Selenium in Biological Systems
- Cardiac tumors and thrombi
- Radiopharmaceutical Chemistry and Applications
- Organ Transplantation Techniques and Outcomes
- Immune Cell Function and Interaction
- Endoplasmic Reticulum Stress and Disease
- Gout, Hyperuricemia, Uric Acid
- Advanced MRI Techniques and Applications
- Evaluation of Teaching Practices
Instituto Tecnológico de Santo Domingo
2023-2024
Universidad Complutense de Madrid
2024
Spanish National Centre for Cardiovascular Research
2010-2022
Instituto de Salud Carlos III
2009
Hospital del Mar Research Institute
2009
Universidad de Murcia
2005-2008
Hospital Universitario Virgen de la Arrixaca
2005-2008
The CD5 lymphocyte surface receptor is a group B member of the ancient and highly conserved scavenger cysteine-rich superfamily. expressed on mature T B1a cells, where it known to modulate activation and/or differentiation processes. Recently, interaction few SRCR members (CD6, Spα, DMBT1) with microbial structures has been reported. Protein binding assays presented herein indicate that ectodomain binds aggregates fungal cells ( Schizosaccharomyces pombe , Candida albicans Cryptococcus...
The retinoid X receptor α (RXRα) plays a central role in the regulation of many intracellular signaling pathways and can mediate ligand-dependent transcription by forming homodimers or heterodimers with other nuclear receptors. Although several members hormone superfamily have emerged as important regulators macrophage gene expression, existence vivo an RXR pathway macrophages has not been established. Here, we provide evidence that RXRα regulates chemokines Ccl6 Ccl9 independently...
CD6 is a lymphocyte receptor that belongs to the scavenger cysteine-rich superfamily. Because some members of superfamily act as pattern recognition receptors for microbial components, we studied whether shares this function. We produced recombinant form ectodomain (rsCD6), which was indistinguishable (in apparent molecular mass, antibody reactivity, and cell binding properties) from circulating affinity-purified human serum. rsCD6 bound aggregated several Gram-positive -negative bacterial...
OBJECTIVE Stereotactic radiosurgery (SRS) is used for the treatment of residual/recurrent nonfunctional pituitary adenoma (NFPA). The aim this study was to evaluate factors related long-term tumor control and delayed endocrinopathies following SRS. METHODS This retrospective, multicenter included patients with recurrent/residual NFPA treated single-fraction SRS; they were then divided into two arms. first arm at least 5 years radiographic follow-up all local progression. second...
Matrix metalloproteinases are involved in vascular remodeling. Little is known about their immune regulatory role atherosclerosis. Here we show that mice deficient for MT4-MMP have increased adherence of macrophages to inflamed peritonea, and larger lipid deposits macrophage burden atherosclerotic plaques. We also demonstrate deficiency results higher numbers patrolling monocytes crawling adhered endothelia, the accumulation Mafb+ apoptosis inhibitor (AIM)+ at incipient lesions mice....
Background and purpose: The mortality associated with acute pancreatitis (AP) is largely attributable to abnormalities that occur in distant organs supportive care remains the only treatment for patients these complications. Recently, prophylactic pharmacological blockade of poly(ADP‐ribose) polymerase (PARP) enzymes has been shown attenuate severity disease. However, clinical relevance PARP inhibitors administered after onset AP uncertain. aim present study was investigate therapeutic...
Objective: Heat stroke is a life-threatening illness characterized by an increased core body temperature as result of exposure to high ambient temperature. Despite advances in supportive care, heat often fatal, and no specific effective therapies exist. The pathophysiological responses involve systemic inflammatory response disseminated intravascular coagulation the host, which lead multiorgan dysfunction syndrome. Poly(ADP-ribose) polymerase-1 (PARP-1) nuclear DNA-binding protein that has...
This review article discussed the challenges faced during implementation of active learning methods within traditional teaching environment at Complutense University Madrid. These encompass interactions with colleagues, students, and classroom itself. It is essential for educators to have confidence that outcomes achieved through these approaches will not be adversely impacted by quality assessment system surveys. The university should adopt a framework differentiates between instructor’s...
Abstract Background Stereotactic radiosurgery (SRS) is used to treat recurrent or residual nonfunctioning pituitary neuroendocrine tumors (NFPA). The objective of the study was assess imaging and development new hormone deficiency. Methods Patients treated with single-session SRS for a NFPA were included in this retrospective, multicenter study. Tumor control dysfunction evaluated using Cox analysis Kaplan–Meier curves. Results A total 869 patients (male 476 [54.8%], median age at 52.5 years...
Microvascular dysfunction and resulting tissue hypoxia is a major contributor to the pathogenesis evolution of cardiovascular diseases (CVD). Diverse gene cell therapies have been proposed preserve microvasculature or boost angiogenesis in CVD, with moderate benefit. This study tested vivo impact sequential delivery by bone-marrow (BM) cells pro-angiogenic factors vascular endothelial growth factor (VEGFA) sphingosine-1-phosphate (S1P) myocardial infarction model. For that, mouse BM were...
In vivo determination of regional pulmonary blood flow (PBF) is a valuable tool for the evaluation many lung diseases. this study, use 68Ga-DOTA PET in quantitative PBF proposed. This methodology was implemented and tested healthy pigs validated using fluorescent microspheres. The study performed on young large white (n = 4). To assess reproducibility consistency method, three scans were obtained each animal. Each radiotracer injection simultaneously to images generated applying...
Objective: 18 F-sodium fluoride ( F-NaF) positron emission tomography (PET) imaging is thought to visualize active atherosclerotic plaque calcification. This supported by the binding of F-NaF calcification ex vivo, but no prior studies have examined human-like in vivo. Our aim was validate specificity PET for calcifications minipigs. Approach and Results: Gain-of-function PCSK9 D374Y (proprotein convertase/subtilisin kexin type 9) transgenic Yucatan minipigs (n=4) were fed high-fat diet 2.5...
In liver cirrhosis, elevated levels of NO and ROS (reactive oxygen species) might greatly favour the generation peroxynitrite. Peroxynitrite is a highly reactive oxidant it can potentially alter vascular reactivity function different organs. present study, we evaluated whether peroxynitrite are related to progression renal excretory dysfunction during experimental cirrhosis induced by chronic BDL (bile-duct ligation) in rats. Experiments were performed at 7, 15 21 days after rats post-BDL...
Stereotactic radiosurgery (SRS) represents an effective treatment for nonfunctioning pituitary adenomas (NFPAs). However, no data have yet been published regarding results of SRS on NFPAs after multiple previous resections.