A5028046604- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Pituitary Gland Disorders and Treatments
- Head and Neck Surgical Oncology
- Vascular Malformations Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Cerebrospinal fluid and hydrocephalus
- Adrenal and Paraganglionic Tumors
- Facial Nerve Paralysis Treatment and Research
- Sinusitis and nasal conditions
- Spinal Fractures and Fixation Techniques
- Trigeminal Neuralgia and Treatments
- Medical Imaging Techniques and Applications
- Advanced Radiotherapy Techniques
- Intracranial Aneurysms: Treatment and Complications
- Radiopharmaceutical Chemistry and Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Cerebral Venous Sinus Thrombosis
- Management of metastatic bone disease
- Salivary Gland Tumors Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Cardiac Imaging and Diagnostics
- Cancer, Hypoxia, and Metabolism
University of Miami
2020-2025
University of Miami Health System
2022-2025
Neurological Surgery
2020-2025
Universidade Presbiteriana Mackenzie
2024
Steadman Clinic
2024
Orthopedic Institute
2024
University of Iowa
2024
Jackson Memorial Hospital
2020-2023
University of Miami Hospital
2023
Jackson Health System
2021
<h3>Objective:</h3> Because the d-2-hydroxyglutarate (D2HG) product of mutant isocitrate dehydrogenase 1 (IDH1<sup>mut</sup>) is released by tumor cells into microenvironment and structurally similar to excitatory neurotransmitter glutamate, we sought determine whether IDH1<sup>mut</sup> increases risk seizures in patients with glioma, D2HG electrical activity neurons. <h3>Methods:</h3> Three WHO grade II-IV glioma cohorts from separate institutions (total N = 712) were retrospectively...
We examined the effects of fetal exposure to a wide range di-(2-ethylhexyl) phthalate (DEHP) doses on fetal, neonatal, and adult testosterone production. Pregnant rats were administered DEHP from Gestational Day (GD) 14 day parturition (Postnatal 0). Exposure between 234 1250 mg/kg/day resulted in increases absolute volumes Leydig cells per testis. Despite this, serum levels reduced significantly compared those controls at all doses. Organ cultures testes GD20 exposed utero showed...
OBJECTIVE Stereotactic radiosurgery (SRS) is used for the treatment of residual/recurrent nonfunctional pituitary adenoma (NFPA). The aim this study was to evaluate factors related long-term tumor control and delayed endocrinopathies following SRS. METHODS This retrospective, multicenter included patients with recurrent/residual NFPA treated single-fraction SRS; they were then divided into two arms. first arm at least 5 years radiographic follow-up all local progression. second...
Abstract Context Little is known about presenting clinical characteristics, tumor biology, and surgical morbidity of Cushing’s disease (CD) with aging. Objective Using a large multi-institutional dataset, we assessed diagnostic prognostic significance age in CD through differences presentation, laboratory results, postoperative outcomes. Design Data from the Registry Adenomas Pituitary Related Disorders (RAPID) were reviewed for patients treated transsphenoidal resection at 11 centers...
INTRODUCTION: Successful surgical treatment of biochemically confirmed Cushing’s Disease (CD) is challenging in patients who have no adenoma visible on preoperative magnetic resonance imaging (MRI). It unclear whether MRI status affects patient outcomes CD. METHODS: In this retrospective study analyzing data from the Registry Adenomas Pituitary and Related Disorders (RAPID), adult with CD were stratified into two groups based presence or absence a imaging. Patients excluded if they had prior...
INTRODUCTION: Reducing length of stay (LOS) and readmission improve healthcare value outcomes. Peri-operative protocols have been shown to facilitate earlier discharge without compromising safety in nonfunctioning adenomas. No multicenter studies investigated their effectiveness Cushing’s Disease (CD). METHODS: A retrospective analysis was conducted from the Registry Adenomas Pituitary Related Disorders (RAPID) consortium with 18 participating centers. Institutions were surveyed regarding...
INTRODUCTION: Radiation necrosis (RN) is a long-term complication of Gamma-Knife (GK) Radiosurgery, an established treatment for metastatic brain tumors. Few dosimetric parameters have shown to predict RN, including tumor target volume, dose, and V12 Gy (volume normal receiving 12 Gy). Vascularity has yet be explored as independent predictor RN. METHODS: All patients treated with GK between 2014-2019 were retrospectively screened post-treatment radiographic Vascular overlap, defined by the...
INTRODUCTION: Stereotactic radiosurgery (SRS) is used to treat residual and recurrent nonfunctioning pituitary adenomas (NFPA). Hypopituitarism the most common complication with increasing rates over time. We present largest multicentric cohort evaluating outcomes after for NFPA. METHODS: Twelve centers contributed retrospective data on 869 patients treated SRS between 1992 2022. Tumor progression was defined as a volumetric increase of =20% from baseline. New-onset hypopituitarism...
Cerebral venous sinus thrombosis (CVST) is a known complication of surgeries near the major dural sinuses. While majority CVSTs are asymptomatic, severe thromboses can have devastating consequences. The objective this study was to prospectively evaluate true incidence and risk factors associated with postoperative CVST comment on management strategies.
OBJECTIVE In the era in which more patients with greater numbers of brain metastases (BMs) are being treated stereotactic radiosurgery (SRS) alone, it is critical to understand how patient, tumor, and treatment factors affect functional status overall survival (OS). The authors examined outcomes dosimetry structures Gamma Knife (GKRS) for ≥ 25 a single session or cumulatively over course their disease. METHODS A retrospective analysis was conducted at institution. institution’s prospective...
Cushing disease (CD) affects mortality and quality of life along with limited long-term remission, underscoring the need to better identify recurrence risk. The identification surgical or imaging predictors for CD remission after transsphenoidal surgery has yielded some inconsistent results been by single-center, single-surgeon, meta-analyses studies. We sought evaluate multicenter Registry Adenomas Pituitary Related Disorders (RAPID) database academic US pituitary centers assess whether...
Abstract BACKGROUND Prior comparisons of brain arteriovenous malformations (AVMs) treated using stereotactic radiosurgery (SRS) with or without embolization were inherently flawed, due to differences in the pretreatment nidus volumes. OBJECTIVE To compare outcomes and SRS, vs SRS alone for AVMs pre-embolization malformation features. METHODS We retrospectively reviewed International Radiosurgery Research Foundation AVM databases from 1987 2018. Patients categorized into (E + SRS) (SRS-only)...