A5059095867- Pituitary Gland Disorders and Treatments
- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- Adrenal and Paraganglionic Tumors
- Glioma Diagnosis and Treatment
- Telemedicine and Telehealth Implementation
- Myasthenia Gravis and Thymoma
- Cerebrospinal fluid and hydrocephalus
- Bone Tumor Diagnosis and Treatments
- Sarcoma Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Surgical Simulation and Training
- Cardiac, Anesthesia and Surgical Outcomes
- Adrenal Hormones and Disorders
- Growth Hormone and Insulin-like Growth Factors
- Cerebral Venous Sinus Thrombosis
- Patient Satisfaction in Healthcare
- Medical Imaging and Analysis
- Sinusitis and nasal conditions
- Traumatic Brain Injury and Neurovascular Disturbances
- Ophthalmology and Eye Disorders
- Trigeminal Neuralgia and Treatments
- COVID-19 and healthcare impacts
- Migraine and Headache Studies
- Thyroid and Parathyroid Surgery
Thomas Jefferson University
2021-2025
Thomas Jefferson University Hospital
2020-2024
Neurological Surgery
2022-2023
Jefferson Hospital for Neuroscience
2022
BACKGROUND AND OBJECTIVES: To address the lack of a multicenter pituitary surgery research consortium in United States, we established Registry Adenomas Pituitary and Related Disorders (RAPID). The goals RAPID are to examine surgical outcomes, improve patient care, disseminate best practices, facilitate at scale. Our initial focus is Cushing disease (CD). This study aims describe current cohort, explore lay foundation for future studies addressing limitations previous studies. METHODS:...
Cushing disease (CD) affects mortality and quality of life along with limited long-term remission, underscoring the need to better identify recurrence risk. The identification surgical or imaging predictors for CD remission after transsphenoidal surgery has yielded some inconsistent results been by single-center, single-surgeon, meta-analyses studies. We sought evaluate multicenter Registry Adenomas Pituitary Related Disorders (RAPID) database academic US pituitary centers assess whether...
Despite growing interest in how patient frailty affects outcomes (eg, neuro-oncology), its role after transsphenoidal surgery for Cushing disease (CD) remains unclear. We evaluated the effect of on CD using Registry Adenomas Pituitary and Related Disorders (RAPID) data set from a collaboration US academic pituitary centers. Data consecutive surgically treated patients with (2011-2023) were compiled 11-factor modified index. Patients classified as fit (score, 0-1), managing well 2-3), mildly...
Dural tails are thickened contrast-enhancing portions of dura associated with some meningiomas. Prior studies have demonstrated the presence tumor cells within dural tail, however their inclusion in radiation treatment fields remains controversial. We evaluated role including tail when treating a meningioma stereotactic and impact on recurrence.This is retrospective, single-institution, cohort study patients intracranial World Health Organization (WHO) grade 1 identified who were treated...
Introduction Pituitary adenomas (PAs) are one of the most common types intracranial neoplasm with increased incidence in elderly patients. The outcomes endoscopic transsphenoidal surgery (ETS) specifically on patients remain unclear. Methods We performed a retrospective cohort study to compare (age ≥65 years) nonelderly <65 who underwent ETS for PA from January 2005 December 2020. Surgical outcomes, including extent resection, complication profile, length stay, and endocrinopathy rates, were...
Introduction: Wide variations exist in the management of craniopharyngiomas including choice surgical approach, extent resection, use adjuvant therapy, and decision regarding pituitary stalk preservation. These practice patterns differ among surgeons likely evolve with experience. The objective this study is to examine our pattern across 15 years using endoscopic endonasal approach for resection effects preservation or sacrifice.
Abstract Introduction Wide variations exist in the management of craniopharyngiomas, including pituitary stalk preservation/sacrifice. This study examines practice patterns over 16 years using endoscopic endonasal approach for resection craniopharyngiomas and it effects preservation. Methods Retrospective analysis was conducted 66 patients who underwent transsphenoidal surgery craniopharyngiomas. Patients were stratified into three epochs: 2005 to 2009 (N = 20), 2010 2015 23), 2016 2020...
Background Chordomas are histologically benign but locally aggressive tumors with a high propensity to recur. Our case highlights the importance of long-term vigilance in patients who have undergone chordoma resection. Case Report We report 47-year-old man cervical developed multiple musculoskeletal ectopic recurrences left supraclavicular region, proximal right bicep, and submandibular region without recurrence primary tumor site. Primary resection was achieved via combination surgery,...
Objective: Cushing's disease (CD) significantly impacts patients' quality of life and has been shown to have high recurrence rates, underscoring the need better identify those factors involved with recurrence. Identification nonhormonal predictors for CD remission after transsphenoidal surgery yielded inconsistent results. We sought evaluate multicenter Registry Adenomas Pituitary Related Disorders (RAPID) database assess whether robust intercenter could be elucidated.
Objective: Attention to the impact of patient frailty on outcomes has grown in neuro-oncology due longer survival after diagnosis, improved surgical treatments, and its relationship postoperative outcomes. The role Cushing's disease (CD) remains unclear we sought evaluate using multicenter Registry Adenomas Pituitary Related Disorders (RAPID) dataset.
Introduction: Unplanned readmission to the hospital following neurosurgical procedures is costly and burdensome patients physicians an important quality metric. Examining unplanned readmissions allows centers gauge progress, identify areas for improvement, develop high impact clinical pathways. Patients with Cushing's disease (CD) experience greater comorbidities more complicated perioperative courses than other pituitary surgery patients, but no studies have focused on in this challenging...
Introduction In pituitary adenomas (PAs), the use of postoperative steroid supplementation remains controversial, as it reduces peritumoral edema and sinonasal complaints but disrupts detection adrenal insufficiency (AI). It is unclear whether cortisol has a measurable effect on improving outcomes in patients with adenoma undergoing endoscopic transsphenoidal surgery (ETS). The objective study was to evaluate treatment protocol various surgical PA ETS. Methods A retrospective cohort...
While multiple studies have evaluated the length of stay after endonasal transsphenoidal surgery (ETS) for pituitary adenoma, potential early discharge on postoperative day 1 (POD 1) remains unclear. The authors compared patients discharged POD with > to better characterize factors that facilitate ETS.
Introduction: Though histologically benign, chordomas are often locally aggressive and have a high propensity to recur even with surgery radiation. Most recurrences local; however, surgical tract dissemination distant metastases also been reported. most originate from primary sacrococcygeal chordomas, cervical show metastatic spread. We report the case of 47-year-old man chordoma who developed musculoskeletal ectopic without evidence recurrence in tumor site during either recurrence.
Background: With the advent of more advanced imaging modalities and its widespread use, pituitary incidentalomas (PI) are increasingly being detected at a higher rate than before when patients worked up for nonpituitary–related conditions. Criteria surgical nonsurgical management this clinical entity now clearly delineated previously. This study analyzes our institution's robust experience in operative PIs over 14-year period, making it largest cohort literature.
Introduction: The COVID-19 outbreak led to the rapid adoption of telemedicine by many specialties, including neurosurgery. Despite several options currently available, assessments that are specific patients with neurological diagnoses and cranial nerve deficits remain limited. Our group has developed a novel platform enables undergo neuro-ophthalmic testing on any personal computer from their own home. In this study, we provide detailed account our experience using Myelin Analytics...
Objective: Delayed symptomatic hyponatremia (DSH) is an unpredictable postoperative complication after transsphenoidal pituitary surgery. Universal sodium screening and water restriction are two strategies to prevent the development of DSH. We performed a meta-analysis studies characterizing rate DSH using protocols.
Purpose/Objectives: Modeling local recurrence for patients with meningiomas treated radiotherapy remains a clinical challenge. Prognostic factors such as the extent of resection, grade, Ki-67, and age have been derived from limited institutional series few integrative models available that incorporate imaging features. Machine learning approaches represent potentially useful method non-linear outcome prediction based on an ability to integrate data patient history quantitative metrics...