Objective The objective of this study is to describe the presentation and management sudden sensorineural hearing loss for patients seen in academic community‐based practices within context American Academy Otolaryngology—Head Neck Surgery Foundation’s “Clinical Practice Guideline: Sudden Hearing Loss.” intention use these findings guide implementation strategies quality improvement initiatives as pilot data development clinical research initiatives. Study Design A cross‐sectional with loss....

Objective To analyze the effect of benralizumab in severe eosinophilic asthma (SA) and chronic rhinosinusitis with polyps (CRSwP). Methods Retrospective review patients both SA CRSwP that were treated benralizumab. Asthma controlled test (ACT), pulmonary function metrics (FEV1), Meltzer endoscopic polyp scores, SNOT-22 collected before after at least 4 months therapy. Results 23 included. The mean age time enrollment into therapy was 50.47 ± 17.3 years majority (65.2%, n = 15) males....

Objectives This study aimed to identify escape of small-particle aerosols from a variety masks using simulated breathing conditions. also evaluate the efficacy negative-pressure environment around face in preventing small aerosolized particles. Study Design is an evaluation with specific methodology described below. Setting was performed our institution's fresh tissue laboratory. Subjects and Methods A fixed cadaver head placed controlled black background, were created joss incense sticks...

This study compares the hospital cost of osseointegrated implants for retention an auricular prosthesis to autologous ear reconstruction.Retrospective review.This includes patients who underwent reconstruction either congenital or acquired defects at Duke University Medical Center during 2009 2015.A total nine had repair representing operative ears, and 16 implant 18 ears (two bilateral). The average age was 11.6 years with 56% male versus 40.7 patients. For patients, indications surgery...

3D printing for virtual surgical planning of nasoseptal flap skull base reconstruction is a viable approach. Results indicate improved mucosal preservation but further research needed to define impact on quality life.

Objectives A variety of endonasal sellar repair techniques have been described; many are complex, multilayered, and carry potential morbidity. We propose an effective, technically simple single-layer for select defects, including those with intraoperative cerebrospinal fluid (CSF) leak. Our technique utilizes only a synthetic dural substitute inlay sealant glue without packing or lumbar drainage. Design This is retrospective review-based study. Setting study was conducted at tertiary care...

Objective: The mainstay of treatment in sinonasal malignancy (SNM) is surgery, and when combined with chemoradiation therapy, often leads to the best overall prognosis. Nasal endoscopy essential for post-treatment surveillance along physical exam radiologic evaluation. ability directly visualize sinus cavities after surgery may also improve early detection tumor recurrence another reason potentially advocate these patients. Methods: A retrospective chart review medical records patients...

Abstract Objectives Pain and analgesic requirements after functional endoscopic sinus surgery (FESS) vary widely. This study aims to quantify pain routine FESS determine the most commonly used management regimen. Methods Retrospective chart review of 100 patients who underwent from Oct 2017 May 2019. Patients prospectively completed a daily diary reported levels that were categorized into no (0), mild (1‐3), moderate (4‐7), or severe (8‐10). narcotics, non‐narcotics, combination, none based...

Introduction Pituitary adenomas (PAs) are one of the most common types intracranial neoplasm with increased incidence in elderly patients. The outcomes endoscopic transsphenoidal surgery (ETS) specifically on patients remain unclear. Methods We performed a retrospective cohort study to compare (age ≥65 years) nonelderly <65 who underwent ETS for PA from January 2005 December 2020. Surgical outcomes, including extent resection, complication profile, length stay, and endocrinopathy rates, were...

Abstract Introduction Traditional open mastoidectomy is performed through a retro-auricular incision to expose the mastoid cortex. Few have addressed possibility of performing an endoscopic minimally invasive mastoidectomy. Objective Our objective was test feasibility 1 cm and burr hole. Methods Ten cadaver heads (20 mastoids) were used for this morphometric study. We hole located over antrum. The goals reach predetermined landmarks maximize drilling cancellous bone. Computed tomography (CT)...

Objectives: 1) Determine current complication rates following uvulopalatopharyngoplasty (UPPP) per the American College of Surgeons’ National Surgery Quality Improvement Program 2006‐2010 data (NSQIP). 2) Compare this more diverse sample population to a larger but less VA study (1991‐2001 data). Methods: Using NSQIP database, we examined prospective cohort adults undergoing UPPP for obstructive sleep apnea with or without other simultaneous procedures performed between years 2006 and 2010....

657 Background: Recent trials have demonstrated remarkable efficacy from combined trastuzumab and chemotherapy in the adjuvant setting of breast cancer. However, resistance continues to be problematic. We intended explore possibility presence a gene expression signature for resistance. Methods: Forty-one consecutive carcinoma cases that had amplified HER2 fresh frozen tissue available were collected. Twelve patients treated with trastuzumab, 3 which recurrence. Eleven not 6 Human genome-wide...

This study assessed the utility of current sialendoscopes in paranasal sinuses a cadaveric model and evaluated novel uses for sialendoscopes.Currently available were used visualisation performing interventions sinuses. Ten cadaver heads studied before after dissection. Outcomes included ostia identification, sinus cannulation, success mucosal biopsy collection image clarity.Marchal Erlangen found to be effective both visualising cannulating sphenoid Both types demonstrated poor maxillary...

Abstract Background: WAVE3 regulates actin polymerization and subsequent cell migration leading to enhanced metastatic potential. Based on pilot data that suggested expression was associated with high histologic grade absence of estrogen receptor (ER) we hypothesized would correlate ER status tumor in a matched group breast cancer (BC) patients. alsoanalyzed relation adverse characteristics, distant recurrence (DR) BC specific mortality. Methods: Our institutional database reviewed for...

Objective To describe the safety and efficacy of mometasone furoate-eluting stents in management petrous apex cholesterol granuloma approached through an endonasal endoscopic route assess restenosis rate.

Introduction: Delays in initiation of adjuvant therapy are associated with poorer outcomes patients who have undergone oncological resection for head and neck malignancy. There many potential factors that can contribute to these delays, but unique cancers involve the base skull is create communications produce a leak cerebral spinal fluid (CSF). This study aims evaluate variables may delays postoperative radiotherapy undergoing sinonasal malignancy surgery.

Background: A variety of endonasal sellar repair techniques have been described, many which are complex, expensive, and carry potential morbidity. We previously shown that an onlay layered sheets regenerated oxidized cellulose is inexpensive, simple, adequate reconstruction for the sella in appropriately selected pituitary adenoma patients. The objective this study to review overall sinonasal morbidity associated with simple effective technique.

Introduction: Proportion and duration of survival sinonasal malignancy (SNM) patients has consistently increased in the past decade. However, disease characteristics outcomes elderly are not well defined. This study was performed to analyze SNM patients.

Introduction: Sinonasal malignancies are a group of tumors which tend to be diagnosed late in their disease course and can invade the surrounding cranial base orbit. With ever-improving imaging endoscopic techniques, detailed information about extent sinonasal tumor involvement is increasingly available prior treatment planning. This study evaluates bony erosion anterior (ACB) seen on high resolution computed tomography (CT) predicting bone ACB final histopathology.

Background: With the advent of more advanced imaging modalities and its widespread use, pituitary incidentalomas (PI) are increasingly being detected at a higher rate than before when patients worked up for nonpituitary–related conditions. Criteria surgical nonsurgical management this clinical entity now clearly delineated previously. This study analyzes our institution's robust experience in operative PIs over 14-year period, making it largest cohort literature.

Background: Sinonasal malignancy (SNM) represents a variety of aggressive tumors with high rate local recurrence. Surgery is mainstay treatment and when combined chemotherapy radiation, this often leads to the best overall prognosis. Nasal endoscopy essential for posttreatment surveillance along physical exam radiologic evaluation. The ability directly visualize sinus cavities after surgery may also improve early detection tumor recurrence another reason potentially advocate in these patients.

Background: Many institutions utilize a graded algorithm to dictate sellar reconstruction following transsphenoidal pituitary surgery based on the defect encountered. At our institution, one of three repair techniques are commonly used for surgery: regenerated oxidized cellulose onlay, synthetic dural substitute inlay with sealant glue, or nasoseptal flap (NSF) onlay and glue. The objective this study is assess postoperative healing sphenoid sella these magnetic resonance imaging (MRI)...