A5046678711- Head and Neck Surgical Oncology
- Sinusitis and nasal conditions
- Nasal Surgery and Airway Studies
- Ear and Head Tumors
- Cerebrospinal fluid and hydrocephalus
- Infectious Diseases and Mycology
- Pituitary Gland Disorders and Treatments
- Olfactory and Sensory Function Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Meningioma and schwannoma management
- Tumors and Oncological Cases
- Head and Neck Cancer Studies
- Allergic Rhinitis and Sensitization
- Obstructive Sleep Apnea Research
- Oral and Maxillofacial Pathology
- Tracheal and airway disorders
- Neuroblastoma Research and Treatments
- Cerebral Venous Sinus Thrombosis
- Ear Surgery and Otitis Media
- Polyomavirus and related diseases
- Neurosurgical Procedures and Complications
- Transplantation: Methods and Outcomes
- Intracranial Aneurysms: Treatment and Complications
- Brain Metastases and Treatment
- Otolaryngology and Infectious Diseases
Duke University
2015-2025
Duke University Hospital
2015-2025
Duke Medical Center
2015-2024
Duke University Health System
2020-2023
Gazi University
2022
University of Pennsylvania
2019
Hospital of the University of Pennsylvania
2016
Augusta University
2013-2015
Icahn School of Medicine at Mount Sinai
2008-2013
Mount Sinai Medical Center
2010
SARS-CoV-2 causes profound changes in the sense of smell, including total smell loss. Although these alterations are often transient, many patients with COVID-19 exhibit olfactory dysfunction that lasts months to years. animal and human autopsy studies have suggested mechanisms driving acute anosmia, it remains unclear how persistent loss a subset patients. To address this question, we analyzed epithelial samples collected from 24 biopsies, nine objectively quantified long-term after...
To determine the safety, feasibility, and efficacy of coupling transoral robotic technology with flexible carbon dioxide (CO2) laser for various tumors oropharynx supraglottic larynx.Prospective, pilot trial.Eight patients were enrolled in an IRB-approved prospective trial surgery aid CO2 laser.Seven male early carcinoma or larynx successfully underwent tumor extirpation robot laser. We unable to gain access one female patient. The final pathology revealed seven squamous cell patient adenoid...
BACKGROUNDPresbyosmia, or aging-related olfactory loss, occurs in a majority of humans over age 65 years, yet remains poorly understood, with no specific treatment options. The epithelium (OE) is the peripheral organ for olfaction and subject to acquired damage, suggesting likely site pathology aging. Adult stem cells reconstitute neuroepithelium response cell loss under normal conditions. In aged OE, patches respiratory-like metaplasia have been observed histologically, consistent failure...
The global Assessing long-teRm Outcomes in dupiluMAb (AROMA) registry study aims to characterize the long-term, real-world use of dupilumab patients with chronic rhinosinusitis nasal polyps (CRSwNP). This paper reports interim analysis baseline characteristics for first 303 enrolled AROMA. AROMA is currently ongoing adult CRSwNP who initiated up 36 months. describes demographics; systemic/oral corticosteroid (SCS/OCS) and antibiotic use; disease burden; healthcare resource utilization;...
Nasal steroids play an important role in the postoperative management of patients with chronic rhinosinusitis (CRS). However, commercially available nasal steroid sprays may not deliver adequate amounts medication to entire sinus cavity. The off-label use budesonide irrigation (BNI) theoretically solves this problem by delivering concentrated solution through a high-pressure, high-volume system. Several studies have attested safety BNI, but there are very few reports its efficacy.This is...
Objective To demonstrate that the supraorbital ethmoid cell (SOEC) is a consistent and reliable landmark in identification of anterior ethmoidal artery (AEA). Study Design Retrospective radiographic study. Setting Tertiary care rhinology practice. Subjects Methods The computed tomography (CT) scans for 78 consecutive patients were evaluated presence SOECs, degree pneumatization, location AEA relation to fixed anatomic structures. Forty‐one with normal SOECs identified compared group 15...
The olfactory epithelium undergoes neuronal regeneration from basal stem cells and is susceptible to neuroblastoma (ONB), a rare tumor of unclear origins. Employing alterations in Rb1/Trp53/Myc (RPM), we establish genetically engineered mouse model high-grade metastatic ONB exhibiting NEUROD1
Background Lung transplantation has revolutionized the treatment of end‐stage pulmonary disease due to cystic fibrosis. However, infection transplanted lungs can lead serious complications, including graft failure and death. Although many these patients have concurrent sinusitis, it is unclear whether bacteria from sinuses infect allograft. Methods This a single‐institution retrospective study all who underwent lung for fibrosis 2005 2015 at Duke University Hospital. Pre‐ posttransplant...
Objective To determine whether treatment of sinonasal squamous cell carcinoma (SCC) at a high‐volume facility affects survival. Study Design Retrospective database analysis. Setting National Cancer Database (2004‐2014). Subjects and Methods The was queried for SCC from 2004 to 2014. Patient demographics, tumor characteristics classification, resection margins, regimen, case‐specific volume—averaged per year grouped in tertiles as low (0%‐33%), medium (34%‐66%), high (67%‐100%)—were compared....
Most human subjects infected by SARS-CoV-2 report an acute alteration in their sense of smell, and more than 25% COVID patients lasting olfactory dysfunction. While animal studies autopsy tissues have suggested mechanisms underlying loss the pathophysiology that underlies persistent smell remains unclear. Here we combine objective measurements suffering from post-acute sequelae infection (PASC) with single cell sequencing histology epithelium (OE). This approach reveals OE harbors a diffuse...
Abstract Objective This study aims to characterize concurrent nasal symptoms in a cohort of patients with non‐rhinogenic headache (NRH) presenting an otolaryngology clinic. Study Design A prospective cohort. Setting Single tertiary care institution. Methods Adults NRH were recruited over 2‐year period (February 2021 February 2023). Patients eligible if they endorsed midfacial pain or pressure for at least 10 days month the previous 3 months and had no evidence rhinosinusitis on both...
Background and Objectives: Endothelial cells are essential to various therapeutic strategies for cardiovascular diseases. Developing efficient methods generate large quantities of well-defined endothelial could improve treatment. This study explored the impact lab-on-a-chip technology on differentiation potential mesenchymal stem derived from human inferior nasal turbinate (hNTSCs). Materials Methods: hNTSCs were isolated five patients divided into two groups: an experimental group subjected...
ABSTRACT Objective Facial pain/pressure is often non‐rhinogenic and migraine‐related in etiology. However, this frequently misdiagnosed as sinusitis, leading to inappropriate antibiotic utilization unnecessary procedures. We assessed the utility of 3‐Item Identify Migraine (ID Migraine) 22‐Item Sinonasal Outcomes Test (SNOT‐22) differentiating rhinogenic vs. facial (NRFP). Methods Patients presenting rhinology clinic with a complaint completed ID SNOT‐22. A diagnosis CRS or NRFP was given...
OBJECTIVE To optimize neurosurgical tumor resection, tissue types and borders must be appropriately identified. Authors of this study established the use a nondestructive laser-based endogenous fluorescence spectroscopy device, "TumorID," to almost immediately classify specimen as glioma, meningioma, pituitary adenoma, or nonneoplastic in operating room, utilizing machine learning algorithm. METHODS TumorID requires only 0.5 seconds collect data, without need for any dyes manipulation,...
Olfactory loss impacts >12% of the population and increases with aging. Multiple conditions can cause smell (hyposmia or anosmia), including post-viral damage from COVID-19 influenza, head injuries, sinusitis, neurodegenerative such as Alzheimer's Parkinson's disease. While treatments surgery, anti-inflammatories olfactory training may be benefit in specific cases, there is an unmet need for effective therapies many common causes dysfunction, especially those thought to due neurons that have...
To demonstrate that quality-of-life outcomes after endoscopic sinus surgery are not compromised in patients with Samter's triad (asthma, nasal polyps, aspirin sensitivity) when compared to eosinophilic chronic rhinosinusitis polyposis (eCRSwP) who sensitive.Retrospective review of prospectively collected data.Thirty-two were identified from a patient database 2003 2012. Preoperative and postoperative symptom endoscopy scores those 37 consecutive eCRSwP sensitive (control). Student t test...
Objectives/Hypothesis Responsible prescribing of postoperative pain medications is necessary in combatting the current opioid epidemic United States. The goal this study was to determine which clinical factors affect usage following functional endoscopic sinus surgery (FESS). Study Design Retrospective medical records study. Methods This a single‐institution retrospective subjects undergoing FESS by senior author between September 2016 and December 2017. Opioid assessed for each patient at...