A5021701327- Pituitary Gland Disorders and Treatments
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- Adrenal and Paraganglionic Tumors
- Brain Metastases and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Venous Thromboembolism Diagnosis and Management
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Surgical Simulation and Training
- Medical Malpractice and Liability Issues
- Cerebrospinal fluid and hydrocephalus
- Biomedical Ethics and Regulation
- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Healthcare cost, quality, practices
- Ferroptosis and cancer prognosis
- Central Venous Catheters and Hemodialysis
- Cancer, Lipids, and Metabolism
- Intracranial Aneurysms: Treatment and Complications
- Tea Polyphenols and Effects
- Ethics in Clinical Research
- Health Systems, Economic Evaluations, Quality of Life
- Trauma and Emergency Care Studies
University of Southern California
2021-2025
Neurological Surgery
2021-2025
Brigham and Women's Hospital
2015-2024
Harvard University
2005-2024
State Street (United States)
2021-2023
University of Alberta
2022
Keck Hospital of USC
2021
Men's Health Boston
2020
Boston Children's Hospital
2019
Medisch Centrum Haaglanden
2018
Glioma is the most commonly occurring malignant brain tumor in United States, and its incidence varies by age, sex, race or ethnicity. Survival after diagnosis has been shown to vary these factors.
Chimeric antigen receptor T cell therapy has become an important tool in the treatment of relapsed and refractory malignancy; however, it is associated with significant neurological toxicity. We characterized toxicity chimeric T-cell a consecutive series 100 patients up to 2 months post transfusion, 28 whom were obtained from chart review others by prospective observation. The underlying neoplasms lymphoma (74%), myeloma (14%), leukaemia (10%), sarcoma (2%). median age cohort was 64.5 years...
VEGF is upregulated in glioblastoma and may contribute to immunosuppression. We performed a phase II study of pembrolizumab alone or with bevacizumab recurrent glioblastoma.Eighty bevacizumab-naïve patients were randomized (cohort A, n = 50) monotherapy B, 30). The primary endpoint was 6-month progression-free survival (PFS-6). Assessed biomarkers included evaluation tumor programmed death-ligand 1 expression, tumor-infiltrating lymphocyte density, immune activation gene expression...
Increased risk of neurological and psychiatric conditions after traumatic brain injury (TBI) is well-defined. However, cardiovascular endocrine comorbidity TBI in individuals without these comorbidities associations with post-TBI mortality have received little attention.To assess the incidence cardiovascular, endocrine, neurological, patients mild (mTBI) or moderate to severe (msTBI) analyze between mortality.This prospective longitudinal cohort study used hospital-based patient registry...
OBJECTIVE The present study aimed to investigate the association between pituitary adenoma (PA) consistency and other measurable tumor characteristics, extent of resection (EOR), postoperative complications, outcomes. METHODS In total, 507 PA resections were intraoperatively assigned a grade from 1 (cystic/hemorrhagic tumors) 5 (calcified based on intraoperative characteristics. Tumor was analyzed in tertiles (grades 2, 3, grades 4 5) determine associations with EOR, recurrence, outcomes,...
Abstract BACKGROUND Although survival statistics in patients with glioblastoma multiforme (GBM) are well-defined at the group level, predicting individual patient remains challenging because of significant variation within strata. OBJECTIVE To compare statistical and machine learning algorithms their ability to predict GBM deploy best performing model as an online calculator. METHODS Patients undergoing operation for a histopathologically confirmed were extracted from Surveillance...
Background Multiple studies have reported higher rates of glioma in areas with socioeconomic status (SES) but to the authors' knowledge not stratified by other factors, including race/ethnicity or urban versus rural location. Methods The authors identified average annual age‐adjusted incidence and calculated hazard ratios for death gliomas various subtypes, a county‐level index SES, race/ethnicity, US region, status. Results Rates were highest counties SES (rate ratio, 1.18; 95% CI,...
While chronic neurological effects from concussion have been studied widely, little is known about possible links between and long-term medical behavioral comorbidities. We performed a retrospective cohort study of 9205 adult patients with concussion, matched to non-concussion controls hospital-based electronic registry. Patients comorbidities before the index visit were excluded. Behavioral defined by International Classification Diseases, Ninth Tenth Revision codes. Groups followed for up...
Venous thromboembolism (VTE), including deep venous thrombosis (DVT) and pulmonary embolism (PE), frequently complicates the postoperative course of primary malignant brain tumor patients. Thromboprophylactic anticoagulation is commonly used to prevent VTE at risk intracranial hemorrhage (ICH). We extracted all patients who underwent craniotomy for a from National Surgical Quality Improvement Program (NSQIP) registry (2005–2015) perform time-to-event analysis identify relevant predictors...
Despite improved perioperative management, the rate of postoperative morbidity and mortality after brain tumor resection remains considerably high. To assess rates, causes, timing, predictors major complication, extended length stay (>10 d), reoperation, readmission, death within 30 d craniotomy for primary malignant tumors. Patients were extracted from National Surgical Quality Improvement Program registry (2005-2015) analyzed using multivariable logistic regression. A total 7376 patients...
OBJECT The purpose of this study was to describe complications associated with the endonasal, transsphenoidal approach for treatment adrenocorticotropic hormone (ACTH)-positive staining tumors (Cushing's disease [CD] and silent corticotroph adenomas [SCAs]) performed by 1 surgeon at a high-volume academic medical center. METHODS Medical records from Brigham Women's Hospital were retrospectively reviewed. Selected 82 patients CD who during April 2008-April 2014 had consecutively undergone...