A5112138841- Amyloidosis: Diagnosis, Treatment, Outcomes
- Parathyroid Disorders and Treatments
- Medical Imaging Techniques and Applications
- Sarcoidosis and Beryllium Toxicity Research
- CAR-T cell therapy research
- Prostate Cancer Treatment and Research
- Nanowire Synthesis and Applications
- Lanthanide and Transition Metal Complexes
- Pleural and Pulmonary Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Advancements in Semiconductor Devices and Circuit Design
- Radiopharmaceutical Chemistry and Applications
- Peripheral Artery Disease Management
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging and Pathology Studies
- Bone Tumor Diagnosis and Treatments
- Cardiovascular Effects of Exercise
- Border Security and International Relations
- Dermatological and Skeletal Disorders
- Eosinophilic Disorders and Syndromes
- International Maritime Law Issues
- Viral-associated cancers and disorders
- Vascular Anomalies and Treatments
- Vestibular and auditory disorders
- Neuroscience and Neural Engineering
Brigham and Women's Hospital
2019-2025
Harvard University
2019-2025
Dana-Farber Brigham Cancer Center
2021-2024
Dana-Farber Cancer Institute
2021-2024
Boston Children's Hospital
2021
Children's National
2016
Duke University
2007
Victoria General Hospital
1975
University of Manitoba
1975
Medical Council of Canada
1975
Chimeric antigen receptor T cell therapy has become an important tool in the treatment of relapsed and refractory malignancy; however, it is associated with significant neurological toxicity. We characterized toxicity chimeric T-cell a consecutive series 100 patients up to 2 months post transfusion, 28 whom were obtained from chart review others by prospective observation. The underlying neoplasms lymphoma (74%), myeloma (14%), leukaemia (10%), sarcoma (2%). median age cohort was 64.5 years...
While EEG is frequently reported as abnormal after chimeric antigen receptor (CAR) T-cell therapy, its clinical significance remains unclear. We aim to systematically describe features in a large single-center cohort and correlate them with radiological findings.We retrospectively identified patients undergoing CAR therapy who had continuous EEG. Neurotoxicity grades, detailed neurological symptoms, brain MRI or FDG-PET were obtained. Correlation between findings was assessed.In 81 median...
While most patients with follicular lymphoma (FL) have excellent outcomes frontline chemoimmunotherapy (CIT), a subset of will experience early progression, which is associated poor subsequent outcomes. Novel biomarkers are needed to identify high-risk earlier. We hypothesized that interim positron emission tomography (PET) would predict progression-free survival (PFS) in this population. retrospectively identified 128 grade 1–3A FL who had an PET after 2–4 cycles CIT at 2 academic centers....
87 Background: While LuPSMA has a proven overall survival (OS) benefit in patients (pts) with mCRPC who have received prior taxane chemotherapy and androgen receptor pathway inhibitors, there is limited data on outcomes efficacy of subsequent therapy pts LuPSMA. This study aimed to assess the clinical treatment courses after Methods: We queried an IRB-approved prospectively maintained registry evaluate all standard-of-care at our institution between June 2022 July 2023. Clinical pertaining...
Siltuximab may be effective in patients with severe neurotoxicity after chimeric antigen receptor T-cell (CAR-T) therapy by lowering CNS interleukin-6 levels.
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Immune checkpoint inhibition (ICI) can induce progression of pre-existing radiation-induced morphoea beyond the irradiated field and into deeper structures including muscle fascia. Dupilumab, an interleukin-4 receptor antagonist, should be considered in patients with refractory radiation or ICI-induced may allow for continued anticancer treatment.
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Abstract Aims Inflammation has been implicated in the pathogenesis of desmoplakin (DSP) cardiomyopathy, and retrospective studies have described abnormal myocardial fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) findings symptomatic patients eventually diagnosed with DSP cardiomyopathy. We aimed to prospectively investigate if ambulatory cardiomyopathy had FDG uptake PET/CT imaging indicative inflammation they circulating biomarker evidence inflammation....