A5075413243- Sex work and related issues
- COVID-19 Clinical Research Studies
- Gender, Feminism, and Media
- Aviation Industry Analysis and Trends
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- International Law and Aviation
- Body Contouring and Surgery
- Diet and metabolism studies
- Prostate Cancer Treatment and Research
- Religion, Spirituality, and Psychology
- Transportation and Mobility Innovations
- Radiopharmaceutical Chemistry and Applications
- Trauma and Emergency Care Studies
- Management of metastatic bone disease
- Lymphatic System and Diseases
- Air Traffic Management and Optimization
- Muscle metabolism and nutrition
- Food Security and Health in Diverse Populations
- Child Abuse and Trauma
- IgG4-Related and Inflammatory Diseases
- Global Health Workforce Issues
- Intensive Care Unit Cognitive Disorders
- UAV Applications and Optimization
- Neuroendocrine Tumor Research Advances
Dana-Farber Cancer Institute
2023-2025
University of Kansas Medical Center
2024
Mid Cheshire Hospitals NHS Foundation Trust
2024
University of Tennessee Health Science Center
2022-2023
Le Bonheur Children's Hospital
2023
Boston University
2023
Yale University
2022
Eijkman Institute for Molecular Biology
2021
NIHR Clinical Research Network
2021
National Institute for Health Research
2021
We have isolated and characterised a novel human protein kinase, Cdc2-related kinase with an arginine/serine-rich (RS) domain (CrkRS), that is most closely related to the cyclin-dependent (CDK) family. CrkRS 1490 amino acid protein, largest CDK-related so far isolated. The of 89% identical 46 kDa CHED but outside domains two proteins are completely unrelated. has extensive proline-rich regions match consensus for SH3 WW binding sites, RS predominantly found in splicing factors. ubiquitously...
Objectives/Goals: The creatine (Cr) system is impaired in Alzheimer’s disease (AD). Data show that monohydrate (CrM) supplementation may improve AD symptoms mouse models, but no human studies have been reported. Thus, we investigated whether an eight-week CrM was feasible and associated with increased brain patients AD. Methods/Study Population: Twenty participants probable were allocated to open-label, intervention of 20 g/day CrM. Fasting blood draws taken at baseline, 4-, 8-week visits...
Abstract Introduction: CDK4/6i improve survival in HR+ MBC but efficacy is limited by mechanisms of resistance including MAPK pathway activation. Avutometinib (VS-6766), a RAF/MEK inhibitor, may reverse resistance, and enhances abema’s anti-proliferative effect preclinical studies. The safety tolerability avutometinib combined with abema fulvestrant unknown. Methods: Eligible pts had HR+/HER2- MBC, prior progression on CDK4/6i, measurable/evaluable disease. Prior was allowed not required....
Palliative care focuses on improving quality of life (QoL). This study examined the feasibility Icelandic version a provisional European Organisation for Research and Treatment Cancer (EORTC) measure spiritual well-being (SWB), explored relationship between SWB QoL palliative patients in Iceland. Instruments from EORTC were used: SWB, which was undergoing pilot-testing Iceland, QLQ C15-PAL. The correlation scores descriptive statistics used. Structured interviews feasibility. Thirty persons...
Paradoxical adipose hyperplasia is a rare adverse event associated with cryolipolysis. No evidence of spontaneous resolution has been described and little written about its treatment. The purpose this report to share the authors' experience treating patients paradoxical after A retrospective chart review was performed for all seen in practice between May 2013 2016. treatment parameters, demographics, onset findings, subsequent were chronicled. Eleven cases identified (eight men three women)....
Objective: Hispanic immigrants represent the largest and fastest growing ethnic minority within US, justifying increased attention to identify factors that influence declining immigrant health across generations. This study investigates range of psychosocial stress exposures coping mechanisms Mexican mothers, implications for their US-born children.Design: We conducted 10 focus groups with 1st generation Mexican-born mothers (n = 32 women) in Nashville, TN, summer 2014. Focus elicited...
Background Periareolar Augmentation Mastopexy is one of the most challenging operations in plastic surgery. Problems with scar quality, areolar widening, and distortion are frequent problems that interfere a predictable result. Methods A retrospective review was performed on fifty consecutive patients who underwent periareolar augmentation mastopexy interlocking approach. Of 50 patients, 30 had both preoperative postoperative photographs were basis study. Results The age ranged from 19 to 56...
87 Background: While LuPSMA has a proven overall survival (OS) benefit in patients (pts) with mCRPC who have received prior taxane chemotherapy and androgen receptor pathway inhibitors, there is limited data on outcomes efficacy of subsequent therapy pts LuPSMA. This study aimed to assess the clinical treatment courses after Methods: We queried an IRB-approved prospectively maintained registry evaluate all standard-of-care at our institution between June 2022 July 2023. Clinical pertaining...
Patients with unstable cervical spine (C-spine) fractures are at a significant risk of respiratory failure. There is no consensus on the optimal timing tracheostomy in setting recent operative fixation (OCF). This study evaluated impact surgical site infections (SSIs) patients undergoing OCF and tracheostomy.Trauma Quality Improvement Program (TQIP) was used to identify isolated injuries who underwent between 2017 2019. Early (<7 days from OCF) compared delayed (≥7 OCF). Logistic regressions...
Summary The challenges of treating malignant disease in the elderly population have gained greater prominence over last 5–10 years. Developed nations all ageing populations, and cancer older people is an increasing physical financial burden on both healthcare systems populations. When assessing oncology patients, oncologists traditionally used Eastern Cooperative Oncology Group or Karnofsky performance status. However, it has been shown that sometimes this does not detect potential problems...
Abstract Background Diminished muscle function and strength are linked to an increased risk accelerated progression of Alzheimer’s disease (AD). Although these direct consequences the disease, recent preclinical evidence suggests decreased may directly influence AD via muscle‐brain axis. Therefore, interventions improve prevent functional decline related AD. However, such specific in lacking. In this context, creatine monohydrate (CrM), a dietary supplement that boosts strength, presents...
INTRODUCTION: Paradoxical adipose hyperplasia (PAH) is a rare complication of cryolipolysis, the most commonly used non-surgical fat reduction technique in world. PAH diagnosed when treated area enlarges over few months after treatment rather than showing subcutaneous fat. In this study, we report our experience with 11 patients seen office diagnosis past 3 years. Their clinical presentation, management, and corrective options are reviewed. METHODS: This retrospective review following...