A5061158281- Spinal Dysraphism and Malformations
- Glioma Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Intracranial Aneurysms: Treatment and Complications
- Cerebrospinal fluid and hydrocephalus
- Spine and Intervertebral Disc Pathology
- Meningioma and schwannoma management
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroblastoma Research and Treatments
- Neurosurgical Procedures and Complications
- Cerebrovascular and Carotid Artery Diseases
- Vascular Malformations Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Pain Management and Opioid Use
- Scoliosis diagnosis and treatment
- Protein Degradation and Inhibitors
- Opioid Use Disorder Treatment
- MRI in cancer diagnosis
- Epilepsy research and treatment
- Congenital Diaphragmatic Hernia Studies
- Simulation-Based Education in Healthcare
- Management of metastatic bone disease
- Functional Brain Connectivity Studies
- Trauma and Emergency Care Studies
- Spinal Cord Injury Research
Columbia University
2021-2024
Neurological Surgery
2017-2024
Columbia University Irving Medical Center
2022-2024
New York College of Health Professions
2022-2023
Washington University in St. Louis
2017-2020
St. Louis Children's Hospital
2018-2020
Mallinckrodt (United States)
2018
Background Multiple studies have reported higher rates of glioma in areas with socioeconomic status (SES) but to the authors' knowledge not stratified by other factors, including race/ethnicity or urban versus rural location. Methods The authors identified average annual age‐adjusted incidence and calculated hazard ratios for death gliomas various subtypes, a county‐level index SES, race/ethnicity, US region, status. Results Rates were highest counties SES (rate ratio, 1.18; 95% CI,...
Neuroinflammation has been implicated in the pathophysiology of post-hemorrhagic hydrocephalus (PHH) prematurity, but no comprehensive analysis signaling molecules performed using human cerebrospinal fluid (CSF). Lumbar CSF levels key cytokines (IL-1α, IL-1β, IL-4, IL-6, IL-8, IL-10, IL-12, TNF-α, TGF-β1, IFN-γ) and chemokines (XCL-1, CCL-2, CCL-3, CCL-19, CXCL-10, CXCL-11, CXCL-12) were measured conventional multiplexed Enzyme-linked Immunosorbent Assays compared between preterm infants...
The focus of this modified Delphi study was to investigate and build consensus regarding the medical management children with moderate severe acute spinal cord injury (SCI) during their initial inpatient hospitalization. This impetus for based on AANS/CNS guidelines pediatric SCI published in 2013, which indicated that there no provided literature describing patients SCIs.An international, multidisciplinary group 19 physicians, including neurosurgeons, orthopedic surgeons, intensivists, were...
Occipital-cervical fusion (OCF) and ventral decompression (VD) may be used in the treatment of pediatric Chiari-1 malformation (CM-1) with syringomyelia (SM) as adjuncts to posterior fossa (PFD) for complex craniovertebral junction pathology.To examine factors influencing use OCF OCF/VD a multicenter cohort CM-1 SM subjects treated PFD.The Park-Reeves Syringomyelia Research Consortium registry was 637 cerebellar tonsillar ectopia ≥ 5 mm, syrinx diameter 3 at least 1 yr follow-up after their...
The subventricular zone (SVZ), housed in the lateral walls of ventricles, is largest neurogenic niche brain. In adults, high-grade gliomas contact or involved with SVZ are associated decreased survival. Whether this association holds true pediatric population remains unexplored. To address gap knowledge, authors conducted retrospective study a treated at three comprehensive centers United States.
Abstract BACKGROUND Histone deacetylase inhibitors have been found preclinically to be among the most active agents against Diffuse Midline Gliomas (DMGs), however, they are clinically ineffective with systemic delivery due low blood brain barrier penetration and toxicity. Using an implantable subcutaneous pump connected a catheter directly implanted into pons we conducted phase I, 3 + dose escalation study investigate safety feasibility of repeated infusions MTX110 (Biodexa Ltd),...
Background Pediatric epilepsy affects 0.5–1% of children, with 10–30% these children refractory to medical anticonvulsant therapy and potentially requiring surgical intervention. Analysis resting state functional MRI (rsMRI) signal temporal differences (latency) has been proposed study the pathological cognitive processes. Purpose/Hypothesis To quantitatively qualitatively analyze correlation rsMRI latency pediatric extratemporal seizure foci lateralization. Study Type Retrospective review....
The goal of this study was to assess the social determinants that influence access and outcomes for pediatric neurosurgical care patients with Chiari malformation type I (CM-I) syringomyelia (SM).The authors used retro- prospective components Park-Reeves Syringomyelia Research Consortium database identify CM-I SM who received surgical treatment had at least 1 year follow-up data. Race, ethnicity, insurance status were as comparators preoperative, treatment, postoperative characteristics...
Abstract Histone deacetylase inhibitors have been found preclinically to be among the most active agents against DMGs, however, they are clinically ineffective with systemic delivery due blood brain barrier limitations and toxicity. Using a repurposed device (implantable subcutaneous pump connected catheter directly implanted into pons/thalamus) we performing phase I, standard 3 + dose escalation study investigate safety feasibility of repeated infusions MTX110 (Midatech Pharma),...
INTRODUCTION: Neurofibromatosis type 2 (NF2) patients develop spinal neoplasms. Determining indications for spine surgery remains challenging, as localization of related symptoms can be confounded by intracranial or peripheral neuropathology. Additionally, patient selection must balanced with pre-existing comorbidities NF2 incurs the goal to maintain improve quality life. METHODS: Seventy-nine were enrolled retrospectively based upon diagnosis and radiographic presence tumors from three...
Phrenic nerve injury can occur anywhere along its course and clinically results in diaphragm paralysis. Although most patients with Parsonage-Turner syndrome phrenic dysfunction improve without treatment, some do not recover spontaneously. In these cases, an initial autoimmune response produces scarring the affected nerve(s). This scar, known as hourglass constriction, causes focal compression of at site which prevents from spontaneously recovering. Thus, authors present a unique case...
OBJECTIVE Solitary posterior fossa low-grade glial tumors (SPFLGT) in children are rarely associated with leptomeningeal dissemination (LMD). To date, there no clear guidelines regarding the role of screening and surveillance spinal MRI (sMRI) SPFLGT, at diagnosis or during follow-up periods. The current study reviews a cohort focusing on sMRI findings. METHODS In this binational retrospective study, authors analyzed 229 patients SPFLGT treated followed over 13 years. One hundred twelve had...
CreveCoeur, Travis S MD; Yahanda, Alexander T MS; Maher, Cormac O Johnson, Gabrielle W BS; Ackerman, Laurie L Adelson, P David Ahmed, Raheel MD, PhD; Albert, Gregory Aldana, Phillipp R Alden, Tord D Anderson, Richard C E Baird, Lissa Bauer, F MPH; Bierbrauer, Karin Brockmeyer, Douglas Chern, Joshua J Couture, Daniel Daniels, Dauser, Robert Durham, Susan Ellenbogen, G Eskandari, Ramin Fuchs, Herbert George, Timothy M Grant, Gerald A Graupman, Patrick Greene, Stephanie Greenfield, Jeffrey...
<h3>Introduction</h3> The Pipeline Embolization Device (PED) has greatly expanded the range of aneurysms amenable to endovascular treatment, including those with wide necks that incorporate branch vessels. Published occlusion rates anterior circulation treated PED typically exceed 85%<sup>1–7</sup> morbidity less than 7%.<sup>7 8</sup> Prompted by this success, is being increasingly utilized for off-label treatment posterior widely varying results.<sup>9 10</sup> purpose study was examine...
BACKGROUND: Graduate surgical education is highly variable across regions and institutions regarding case volume degree of trainee participation in each case. Dedicated educational curriculum using cadaveric tissue has been shown to enhance graduate training, however with associated financial utility burden the institution. OBJECTIVE: To investigate cost applications a novel method combining mixed organic hydrogel polymers 3-dimensional printed anatomic structures create complete...