A5065875311- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Neonatal and fetal brain pathology
- Fetal and Pediatric Neurological Disorders
- Advanced Neuroimaging Techniques and Applications
- Neonatal Respiratory Health Research
- Barrier Structure and Function Studies
- Neuroscience and Neural Engineering
- Bacterial biofilms and quorum sensing
- Acute Ischemic Stroke Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Spinal Dysraphism and Malformations
- Thermal Regulation in Medicine
- Bone Tissue Engineering Materials
- Ion Transport and Channel Regulation
- Cardiac Ischemia and Reperfusion
- Intracerebral and Subarachnoid Hemorrhage Research
- Glioma Diagnosis and Treatment
- Force Microscopy Techniques and Applications
- Legionella and Acanthamoeba research
- Polymer Surface Interaction Studies
- Biomedical Research and Pathophysiology
- Microtubule and mitosis dynamics
- Cellular Mechanics and Interactions
- Nanofabrication and Lithography Techniques
Washington University in St. Louis
2015-2024
St. Louis Children's Hospital
2016-2021
University of Calgary
2021
Mallinckrodt (United States)
2021
Children's Hospital of Orange County
2021
Neurological Surgery
2001-2020
Neurology, Inc
2019
University of Utah
2009-2011
Wayne State University
1998-2009
Primary Children's Hospital
2008-2009
Building on previous National Institutes of Health-sponsored symposia hydrocephalus research, "Opportunities for Hydrocephalus Research: Pathways to Better Outcomes" was held in Seattle, Washington, July 9-11, 2012. Plenary sessions were organized into four major themes, each with two subtopics: Causes (Genetics and Pathophysiological Modifications); Diagnosis (Biomarkers Neuroimaging); Treatment (Bioengineering Advances Surgical Treatments); Outcome (Neuropsychological Neurological)....
Reactive gliosis has the potential to alter biomechanical properties of brain, impede neuronal regeneration and affect plasticity. Determining onset progression reactive astrogliosis microgliosis due hydrocephalus is important for designing better clinical treatments.Reactive were evaluated as severity increased with age in hydrocephalic H-Tx rats control littermates. Previous studies have suggested that may persist after short-term drainage (shunt treatment) cerebrospinal fluid. Therefore...
Neuroinflammation has been implicated in the pathophysiology of post-hemorrhagic hydrocephalus (PHH) prematurity, but no comprehensive analysis signaling molecules performed using human cerebrospinal fluid (CSF). Lumbar CSF levels key cytokines (IL-1α, IL-1β, IL-4, IL-6, IL-8, IL-10, IL-12, TNF-α, TGF-β1, IFN-γ) and chemokines (XCL-1, CCL-2, CCL-3, CCL-19, CXCL-10, CXCL-11, CXCL-12) were measured conventional multiplexed Enzyme-linked Immunosorbent Assays compared between preterm infants...
<i>Objective:</i> Exaggerated nocturnal intracranial pressure (ICP) dynamics are commonly observed in hydrocephalic children with a compromise of CSF compensatory reserve capacity. Successful shunting restores this cerebrospinal reserve. We used ICP overnight monitoring combined positional maneuvers complex suspected shunt malfunction for the assessment function. <i>Methods:</i> In 32 children, we performed 65 computerized recordings and 25 maneuvers. Baseline was...
✓In an effort to identify critical gaps in the prevailing knowledge of hydrocephalus, authors formulated 10 key questions. 1) How do we define hydrocephalus? 2) is cerebrosinal fluid (CSF) absorbed normally and what are causes CSF malabsorption 3) Why ventricles dilate communicating 4) What happens structure function brain when it compressed stretched by expanding ventricles? 5) role cerebrovenous pressure 6) normal-pressure 7) low-pressure 8) pathophysiology slit ventricle syndrome? 9)...
While many reports have documented the effects of hydrocephalus on ependyma and periventricular white matter, primarily in adult animal models, little is known about alterations specific to neurons. The present study has evaluated qualitatively neurons vasculature cerebral cortex a neonatal model. cisterna magna 4 11-day-old kittens was injected with solution 25% kaolin induce hydrocephalus. Ultrasonographic evidence noted within 3–5 days injection. Hydrocephalus progressed until day 18–25...
In an effort to develop novel treatments for communicating hydrocephalus, we have shown previously that the transforming growth factor-β antagonist, decorin, inhibits subarachnoid fibrosis mediated ventriculomegaly; however decorin's ability prevent cerebral cytopathology in hydrocephalus has not been fully examined. Furthermore, capacity diffusion tensor imaging act as a proxy measure of pathology multiple sclerosis and spinal cord injury recently demonstrated. However, use investigate...
Many animal models have been used to study the pathophysiology of hydrocephalus; most these rodent whose lissencephalic cerebral cortex may not respond ventriculomegaly in same way as gyrencephalic species and size is amenable evaluation clinically relevant neurosurgical treatments. Fewer hydrocephalus used; thus, we expanded upon a porcine model juvenile pigs it explore surgical treatment methods.Acquired was induced 33-41-day old by percutaneous intracisternal injections kaolin (n = 17)....
Object. The authors of previous studies have suggested that connectivity within the cerebral cortex may be irreversibly altered by hydrocephalus. To examine connectivity-related changes directly, conducted a study in which they used an axonal tracer animal model infantile Methods. In five hydrocephalic kittens low-pressure ventriculoperitoneal (VP) shunts were placed 10 to 14 days after induction hydrocephalus intracisternal kaolin injections. Wheat germ agglutinin-conjugated horseradish...
Abstract Background Severe intraventricular hemorrhage (IVH) is one of the most devastating neurological complications in preterm infants, with majority suffering long-term morbidity and up to 50% developing post-hemorrhagic hydrocephalus (PHH). Despite importance this disease, its cytopathological mechanisms are not well known. An vitro model IVH required investigate effects blood components on ventricular zone (VZ) stem cell niche. To address need, we developed a protocol from our accepted...
Interpretation of cerebrospinal fluid (CSF) studies can be challenging in preterm infants. We hypothesized that intraventricular hemorrhage (IVH), post-hemorrhagic hydrocephalus (PHH), and infection (meningitis) promote pro-inflammatory CSF conditions reflected parameters. Biochemical cytological profiles lumbar peripheral blood samples were analyzed for 81 control, 29 IVH grade 1/2 (IVH1/2), 13 3/4 (IVH3/4), 15 PHH, 20 culture-confirmed bacterial meningitis (BM), 27 viral (VM) infants at...
Object. In ischemic stroke, the crisis activates a cascade of traumatic events that are potentiated by reperfusion and eventually lead to neuronal degeneration. The primary aim this study was investigate procedure could minimize damage interfering with interactions between reestablished blood flow ischemically damaged tissue, as well improving regional microcirculation. Methods. Using novel hollow filament, authors flushed territory heparinized saline before vascular after occlusion middle...
The neurologic deficits of neonatal post-hemorrhagic hydrocephalus (PHH) have been linked to periventricular white matter injury. To improve understanding PHH-related injury, diffusion basis spectrum imaging (DBSI) was applied in neonates, modeling axonal and myelin integrity, fiber density, extrafiber pathologies. Objectives included characterizing DBSI measures tracts, associating with ventricular size, examining MRI findings the context postmortem histology from similar cases.
Aquaporin-4 (AQP4) plays a crucial role in brain water circulation and is considered therapeutic target hydrocephalus. Congenital hydrocephalus associated with reaction of astrocytes the periventricular white matter both experimental models human cases. A previous report showed that bone marrow-derived mesenchymal stem cells (BM-MSCs) transplanted into lateral ventricles hyh mice exhibiting severe congenital are attracted by astrocyte reaction, cerebral tissue displays recovery. The present...
Hydrocephalus that develops early in life is often accompanied by developmental delays, headaches and other neurological deficits, which may be associated with changes brain shear stiffness. However, noninvasive approaches to measuring stiffness are limited. Magnetic Resonance Elastography (MRE) of the a relatively new imaging method provides quantitative measures tissue Herein, we aimed use MRE assess hydrocephalus patients compared healthy controls, its associations ventricular size, as...
Object Shunt infections and their management remain a clinically important problem in patients with hydrocephalus. The authors evaluated, comparison traditional parameters, C-reactive protein (CRP) blood/serum (S-CRP) cerebrospinal fluid (CSF; C-CRP) for its power to identify treat infected shunts. Methods On 84 different occasions, CSF blood samples from 59 children suspected of having shunt/CSF were obtained evaluated. An infection was proven by culture 35 evaluations. Values S-CRP...