A5006360048- Cerebrospinal fluid and hydrocephalus
- Fetal and Pediatric Neurological Disorders
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience of respiration and sleep
- Neonatal and fetal brain pathology
- Barrier Structure and Function Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurobiology and Insect Physiology Research
- Microtubule and mitosis dynamics
- Wnt/β-catenin signaling in development and cancer
- Axon Guidance and Neuronal Signaling
- Genetic and Kidney Cyst Diseases
- Sleep and Wakefulness Research
- Physiological and biochemical adaptations
- Spinal Dysraphism and Malformations
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Neonatal Respiratory Health Research
- Mitochondrial Function and Pathology
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Nerve injury and regeneration
- Cellular transport and secretion
- Neuropeptides and Animal Physiology
- Congenital heart defects research
Austral University of Chile
2011-2025
Universidad Nacional de Asunción
2024
National Clonal Germplasm Repository for Citrus
2022
University of Groningen
2017
Washington University in St. Louis
2017
Universidad de Málaga
2003-2017
University Medical Center Groningen
2017
Instituto de Investigación Biomédica de Málaga
2017
Institute of Neurobiology
2016
Hospital Infantil de México Federico Gómez
2016
Periventricular heterotopia (PH) is a disorder characterized by neuronal nodules, ectopically positioned along the lateral ventricles of cerebral cortex. Mutations in either two human genes, Filamin A (FLNA) or ADP-ribosylation factor guanine exchange 2 (ARFGEF2) , cause PH (Fox et al. ‘Mutations filamin 1 prevent migration cortical neurons periventricular heterotopia'. Neuron,21, 1315–1325, 1998; Sheen al . ARFGEF2 implicate vesicle trafficking neural progenitor proliferation and cortex'....
Building on previous National Institutes of Health-sponsored symposia hydrocephalus research, "Opportunities for Hydrocephalus Research: Pathways to Better Outcomes" was held in Seattle, Washington, July 9-11, 2012. Plenary sessions were organized into four major themes, each with two subtopics: Causes (Genetics and Pathophysiological Modifications); Diagnosis (Biomarkers Neuroimaging); Treatment (Bioengineering Advances Surgical Treatments); Outcome (Neuropsychological Neurological)....
To determine if ventricular zone (VZ) and subventricular (SVZ) alterations are associated with intraventricular hemorrhage (IVH) posthemorrhagic hydrocephalus, we compared postmortem frontal subcortical brain samples from 12 infants IVH 3 nonneurological disease controls without hemorrhages or ventriculomegaly. Birth expiration estimated gestational ages were 23.0–39.1 23.7–44.1 weeks, respectively; survival ranges 0–42 days (median, 2.0 days). Routine histology immunohistochemistry for...
ABSTRACT Our study was designed to contribute an understanding of the timing and conditions under which transmission Andes hantavirus in Oligoryzomys longicaudatus reservoir populations takes place. Mice were caged test habitats consisting steel drums containing holding cages, where seronegative rodents exposed wild seropositive individuals by freely sharing same cage or being separated a wire mesh. Tests also performed for potential viral mice from excrement-tainted bedding cages. virus...
Fetal-onset hydrocephalus affects 1 to 3 per 1,000 live births. It is not only a disorder of cerebrospinal fluid dynamics but also brain that corrective surgery does ameliorate. We hypothesized cell junction abnormalities neural stem cells (NSCs) lead the inseparable phenomena fetal-onset and abnormal neurogenesis. used bromodeoxyuridine labeling, immunocytochemistry, electron microscopy, culture study telencephalon hydrocephalic HTx rats correlated our findings with those in human...
Two phases may be recognized in the development of congenital hydrocephalus hyh mutant mouse. During embryonic life detachment ventral ependyma is followed by a moderate hydrocephalus. first postnatal week cerebral aqueduct becomes obliterated and severe develops. The aim present investigation was to elucidate cellular phenomena occurring at site obliteration probable participation subcommissural organ this process. Electron microscopy, immunocytochemistry, lectin histochemistry were used...
Hydrocephalic hyh mice are born with moderate hydrocephalus and a normal cerebral aqueduct. At about the fifth postnatal day aqueduct becomes obliterated severe develops. The aim of present investigation was to investigate mechanism this hydrocephalus, probably starting during fetal life when is still patent. By use immunocytochemistry scanning electron microscopy, mutant (n = 54) 61) mouse embryos were studied at various developmental stages trace earliest microscopic changes occurring in...
In human spina bifida aperta (SBA), cerebral pathogenesis [hydrocephalus, Sylvius aqueduct (SA) stenosis and heterotopias] is poorly understood. animal models, loss of ventricular lining (ependymal denudation) causes SA hydrocephalus. We aimed to investigate whether ependymal denudation also takes place in foetal SBA. Considering that would be related alterations junction proteins, sections through five SBA six control foetuses (gestational ages ranged between 37 40 weeks) were immunostained...
Hyh mutant mice develop long-lasting hydrocephalus and represent a good model for investigating neuropathologic events associated with hydrocephalus. The study of their brains by use lectin binding, bromodeoxyuridine labeling, immunochemistry, scanning electron microscopy revealed that certain related to followed well-defined pattern. A program neuroepithelium/ependyma denudation was initiated at embryonic day 12 terminated the end second postnatal week. After third week denuded areas...
Neural stem cells persist after embryonic development in the subventricular zone (SVZ) niche and produce new neural during postnatal life; ependymal are a key component associated with this neurogenic niche. In animal model of human hydrocephalus, hyh mouse, ependyma lateral ventricles is progressively lost late early life disappears from most ventricular surface throughout its span. To determine potential consequences loss on SVZ, we characterized abnormalities mice. There was overall...
Disruption/denudation of the ependymal lining has been associated with pathogenesis various human CNS disorders, including hydrocephalus, spina bifida aperta, and periventricular heterotopia. It traditionally considered that denudation is a consequence mechanical forces such as ventricular enlargement. New evidence indicates disruption can precede dilation, but cellular molecular mechanisms involved in onset are unknown. Here, we present novel model to study cell pathophysiology demonstrate...