A5069470218- Sarcoma Diagnosis and Treatment
- Virus-based gene therapy research
- Cytomegalovirus and herpesvirus research
- Advanced Neuroimaging Techniques and Applications
- Cervical and Thoracic Myelopathy
- MRI in cancer diagnosis
- CAR-T cell therapy research
- Treatment of Major Depression
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Bipolar Disorder and Treatment
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Schizophrenia research and treatment
- Epigenetics and DNA Methylation
- Electroconvulsive Therapy Studies
- Immune Cell Function and Interaction
- HIV Research and Treatment
- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cannabis and Cannabinoid Research
- Mycobacterium research and diagnosis
- Immunotherapy and Immune Responses
- Head and Neck Cancer Studies
- Neuroinflammation and Neurodegeneration Mechanisms
UC Davis Health System
2025
Neurological Surgery
2012-2025
University of California Davis Medical Center
2024
Neuronetics (United States)
2024
Cornell University
2022-2024
Center for Discovery
2024
Intra Cellular Therapies (United States)
2024
Janssen (Switzerland)
2024
Otsuka (United States)
2024
Lundbeck (Germany)
2024
The Polycomb Repressor Complex (PRC) is an epigenetic regulator of transcription whose action mediated by 2 protein complexes, PRC1 and PRC2. PRC oncogenic in glioblastoma, where it involved cancer stem cell maintenance radioresistance. We used a set glioblastoma patient samples, glioma cells, neural cells from mouse model glioblastoma. characterized gene/protein expression cellular phenotypes quantitative PCR/Western blotting clonogenic, cell-cycle, DNA damage assays. performed...
The immune phenotype of a tumour is key predictor its response to immunotherapy1-4. Patients who respond checkpoint blockade generally present with immune-inflamed5-7 tumours that are highly infiltrated by T cells. However, not all inflamed therapy, and even lower rates occur among lack cells (immune desert) or spatially exclude the periphery lesion excluded)8. Despite importance these phenotypes in patients, little known about their development, heterogeneity dynamics owing technical...
Tumor virotherapy has been and continues to be used in clinical trials. One barrier effective viral oncolysis, consisting of the interferon (IFN) response induced by infection, is inhibited valproic acid (VPA) other histone deacetylase inhibitors (HDACi). Innate immune cell recruitment activation have shown deleterious efficacy oncolytic herpes simplex virus (oHSV) this report we demonstrate that VPA limits response. VPA, administered prior oHSV inoculation an orthotopic glioblastoma mouse...
The E2f3 locus encodes two Rb-binding gene products, E2F3a and E2F3b, which are differentially regulated during the cell cycle thought to be critical for progression. We targeted individual inactivation of E2f3a or E2f3b in mice examined their contributions proliferation development. Chromatin immunoprecipitation expression experiments using mouse embryo fibroblasts deficient each isoform showed that E2F3b contribute G1/S-specific proliferation. Expression was sufficient support E2F target...
Treatment-resistant depression, defined as a failure of at least two oral antidepressants adequate dose and duration in the current episode, is debilitating condition with low rates response remission. Intranasal esketamine first medication approved by regulatory authorities for difficult to treat depressive episodes that builds directly on discovery rapid antidepressant effects intravenously administered racemic ketamine. Approved United States 2019, subsequently, many countries worldwide,...
Abstract To study the controversial role of cytomegalovirus (CMV) in glioblastoma, we assessed effects murine CMV (MCMV) perinatal infection a GFAP-cre; Nf1loxP/+; Trp53−/+ genetic mouse model glioma (Mut3 mice). Early on after infection, MCMV antigen was predominantly localized CD45+ lymphocytes brain with active viral replication and local areas inflammation, but, by 7 weeks, there generalized loss brain, confirmed bioluminescent imaging. MCMV-infected Mut3 mice exhibited shorter survival...
In our outpatient pediatric and adult psychiatry centers, we reserve psychostimulants for predominantly inattentive attention deficit hyperactivity disorder (ADHD) due to the potential appetite growth suppression, insomnia, wear off, exacerbation of mood, anxiety, tics, or misuse. We utilize extended-release (ER) alpha-2 agonists primarily hyperactivity/impulsivity but find them less effective inattention, they can cause sedation hypotension. Oftentimes, need combine an agonist behavior with...
Cytomegalovirus (CMV) has been detected in several human cancers, but it not proven to be oncogenic. However, recent studies have suggested mechanisms through which cytomegalovirus may modulate the tumor environment, encouraging its study as a positive modifier of tumorigenesis. In this study, we investigated effects infection Trp53 heterozygous mice. Animals were infected with murine (MCMV) after birth at 2 days (P2) or 4 weeks age and then monitored for formation. Mice injected developed...
Abstract Purpose: Glioblastoma (GBM) is one of the deadliest cancers with no cure. While conventional MRI has been widely adopted to examine GBM clinically, accurate neuroimaging assessment tumor histopathology for improved diagnosis, surgical planning, and treatment evaluation remains an unmet need in clinical management GBMs. Experimental Design: We employ a novel diffusion histology imaging (DHI) approach, combining basis spectrum (DBSI) machine learning, detect, differentiate, quantify...
INTRODUCTION: MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by targeting the mRNAs of a large number human genes. We have previously demonstrated miRNAs could serve as therapeutic agents for glioblastoma (GBM). However, systemically administering genes to central nervous system (CNS) is hindered both blood-brain barrier (BBB) and nanoporous electrostatically charged tissue space, denoted here “brain barrier” (BTB). To overcome these physical barriers we designed...
Over the last decade, cytomegalovirus (CMV) has been suggested to promote development of glioblastoma multiforme (GBM). Recent evidence demonstrates that CMV contributes progression GBM in context oncosuppressor gene mutations. This finding provides further insights into mechanisms whereby exacerbates malignancy GBM.
lanzapine/samidorphan (OLZ/SAM) was released in October 2021 for adults with schizophrenia or bipolar I disorder acute manic mixed episodes and maintenance to prevent and/ depressive episodes. 1Samidorphan is a novel μ-opioid receptor antagonist κ-opioid δ-opioid partial agonist associated regulation of appetite metabolism. 2 Samidorphan has longer half-life than naltrexone 5 times the blockade 3 that mitigates weight gain from olanzapine. 4 The following are representative cases drawn...
Analysis of anterior cervical microforaminotomy performed at the North Staffordshire University Hospital along with a review literature this minimally invasive procedure is presented.A retrospective-prospective study was on 34 patients (24 males, 10 females) disc disease who had been surgically treated between 1999 and 2005. Age ranged from 37 to 75. MRI findings were prolapse in 28 additional osteophytes six. Microforaminotomy according published technique.Single level operations 22 (21...
Alveolar soft part sarcoma (ASPS) is an exquisitely rare of unknown histogenesis, with a predilection for adolescents and young adults, characterized by slow progressive clinical course high frequency metastases. They are traditionally chemoresistant very limited treatment options in the metastatic setting. Human cytomegalovirus (HCMV) DNA β-herpes virus it persistent lifelong latent infection. There growing evidence to indicate presence HCMV proteins nucleic acids glioblastoma,...
The authors describe 2 cases of triventricular hydrocephalus initially presenting as aqueductal stenosis that subsequently developed tumors the pineal and tectal region. first case resembled late-onset idiopathic on serial imaging. Subsequent imaging revealed a new tumor in region causing mass effect midbrain. second presented more typical pattern during infancy. On delayed follow-up imaging, an enlarging was discovered. In both successfully treated by cerebrospinal fluid diversion prior to...
INTRODUCTION: Neurofibromatosis type 2 (NF2) patients develop spinal neoplasms. Determining indications for spine surgery remains challenging, as localization of related symptoms can be confounded by intracranial or peripheral neuropathology. Additionally, patient selection must balanced with pre-existing comorbidities NF2 incurs the goal to maintain improve quality life. METHODS: Seventy-nine were enrolled retrospectively based upon diagnosis and radiographic presence tumors from three...
Background: Cervical spinal cord injuries (SCIs) are the most common type of human SCI. Although various animal SCI contusion models have been developed to mirror pathology, few described cervical-level injuries. This study aims validate and establish optimal impact parameters produce consistent incomplete cervical SCIs for testing novel therapies. Methods: Using a precise impactor, 3 hemi-contusions varying severities were induced by modifying penetration depths controlling dwell times....