A5022333824- Spine and Intervertebral Disc Pathology
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Glioma Diagnosis and Treatment
- Scoliosis diagnosis and treatment
- Spinal Cord Injury Research
- Pelvic and Acetabular Injuries
- Transcranial Magnetic Stimulation Studies
- Musculoskeletal pain and rehabilitation
- Intraoperative Neuromonitoring and Anesthetic Effects
- Nerve Injury and Rehabilitation
- Neurofibromatosis and Schwannoma Cases
- Spinal Fractures and Fixation Techniques
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Management of metastatic bone disease
- Spinal Hematomas and Complications
- CAR-T cell therapy research
- Immune cells in cancer
- Clinical practice guidelines implementation
- Meningioma and schwannoma management
- Neonatal and fetal brain pathology
- Opioid Use Disorder Treatment
- Case Reports on Hematomas
- Brain Metastases and Treatment
Columbia University
2002-2025
Neurological Surgery
2002-2025
NewYork–Presbyterian Hospital
2017-2025
Texas Health Dallas
2022-2024
Columbia University Irving Medical Center
2015-2022
New York Hospital Queens
2022
The Neurological Institute
2002-2007
Brigham and Women's Hospital
2007
Harvard University
2007
Boston Children's Hospital
2006
Immunosuppression by gliomas contributes to tumor progression and treatment resistance. It is not known when immunosuppression occurs during development but it likely involves cross-talk among cells, tumor-associated macrophages microglia (TAMs), peripheral as well tumor-infiltrating lymphocytes (TILs).We have performed a kinetic study of this immunomodulation, assessing the dynamics immune infiltration function, within central nervous system (CNS) peripherally. PDGF-driven murine glioma...
Study Design. Clinical retrospective study. Objective. The authors aim to analyze the relationship between paraspinal muscle degeneration and degree of L4-5 Degenerative lumbar spondylolisthesis (DLS). Summary Background Data. While is thought contribute severity, this has yet be fully characterized. Methods. A analysis was performed all neurosurgical patients admitted Columbia Neurosurgery Spine Division for treatment DLS January 2018 March 2024. Preoperative lumbopelvic parameters slip...
The purpose of this study was to determine the incidence, mechanism, and potential protective strategies for pelvic fixation failure (PFF) within 2 years after adult spinal deformity (ASD) surgery.Data ASD patients (age ≥ 18 years, minimum six instrumented levels) with (S2-alar-iliac [S2AI] and/or iliac screws) a 2-year follow-up were consecutively collected (2015-2019). Patients prior excluded. PFF defined as any revision screws, which may include broken rods across lumbosacral junction...
INTRODUCTION: Degenerative spondylolisthesis (DS) is a common cause of lumbar stenosis and potentially dynamic instability that frequently causes radiculopathy. While paraspinal muscle degeneration thought to contribute severity, this relationship has yet be fully characterized. METHODS: A retrospective analysis was performed all neurosurgical patients admitted the Columbia Neurosurgery Spinal Division for treatment L4-5 DS between January 2018 March 2024. Preoperative lumbopelvic parameters...
Abstract We have shown that a COOH-terminal peptide of p53 (amino acids 361–382, p53p), linked to the truncated homeobox domain Antennapedia (Ant) as carrier for transduction, induced rapid apoptosis in human premalignant and malignant cell lines. Here, we report rat glioma lines containing endogenous mutant or wild-type (WT) were into by exposure this called p53p-Ant. The was comparatively nontoxic proliferating nonmalignant glial WT normal peripheral marrow blood stem cells. Degree...
OBJECTIVE Lack of human leukocyte antigens and costimulatory molecules have been suggested as mechanisms by which malignant gliomas avoid immune recognition elimination. METHODS Using quantitative multiparameter flow cytometric analysis, tumor cells from patients with glioblastoma multiforme (n = 18) were examined ex vivo for the expression antigen Class I II B7-1 B7-2. They compared reactive astrocytes peritumoral brain metastases 7), removed during nontumor surgery 5). RESULTS In contrast...
OBJECTIVE The capacity for local infection to prolong survival in patients with cancer is a widely accepted but unsubstantiated principle. neurosurgical literature contains anecdotal reports of malignant gliomas who experienced prolonged remission their tumors after bacterial infection. This association has not been explored larger series glioma postoperative infections. METHODS A single-center operative experience accumulated over 10 years was examined evaluate whether infections conferred...
Delphi method.To gain consensus on the following questions: (1) When should anticoagulation/antiplatelet (AC/AP) medication be stopped before elective spine surgery?; (2) AC/AP restarted after (3) When, how, and in whom venous thromboembolism (VTE) chemoprophylaxis started spinal surgery?VTE can lead to significant morbidity adult surgery, yet postoperative VTE prophylaxis practices vary considerably. The management of preoperative is similarly heterogeneous.Delphi method development...
There is a paucity of literature on pelvic fixation failure after adult spine surgery in the early postoperative period. The purpose this study was to determine incidence acute large single-center and describe lessons learned.The authors performed retrospective review (≥ 18 years old) patients who underwent spinal fusion with (iliac, S2-alar-iliac [S2AI] screws) at single academic medical center between 2015 2020. All had minimum 3 instrumented levels. follow-up 6 months index surgery....
Although epidural stimulation of the lumbar spinal cord has emerged as a powerful modality for recovery movement, how it should be targeted to cervical activate arm and hand muscles is not well understood, particularly in humans. We sought map muscle responses posterior hypothesized that lateral over dorsal root entry zone would most effective strongest innervated by stimulated segment. Twenty-six people undergoing clinically indicated spine surgery consented mapping motor responses. During...
INTRODUCTION: Neurofibromatosis type 2 (NF2) patients develop spinal neoplasms. Determining indications for spine surgery remains challenging, as localization of related symptoms can be confounded by intracranial or peripheral neuropathology. Additionally, patient selection must balanced with pre-existing comorbidities NF2 incurs the goal to maintain improve quality life. METHODS: Seventy-nine were enrolled retrospectively based upon diagnosis and radiographic presence tumors from three...
Volitional movement requires descending input from the motor cortex and sensory feedback through spinal cord. We previously developed a paired brain electrical stimulation approach in rats that relies on convergence of stimuli cervical This strengthened sensorimotor circuits improved volitional associative plasticity. In humans, it is not known whether posterior epidural cord targeted at interface or anterior within system effective facilitating evoked responses. 59 individuals undergoing...