A5005246900- Trauma and Emergency Care Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Maternal and fetal healthcare
- Pregnancy and preeclampsia studies
- Trauma Management and Diagnosis
- Abdominal Trauma and Injuries
- Pelvic and Acetabular Injuries
- Combustion and Detonation Processes
- Maternal and Perinatal Health Interventions
- Pharmacological Effects and Toxicity Studies
- Fire dynamics and safety research
- Risk and Safety Analysis
- Sepsis Diagnosis and Treatment
- Disaster Response and Management
- Venous Thromboembolism Diagnosis and Management
- Renal and Vascular Pathologies
- Optical Imaging and Spectroscopy Techniques
- Non-Invasive Vital Sign Monitoring
- Cardiac, Anesthesia and Surgical Outcomes
- High-Velocity Impact and Material Behavior
- Cardiovascular Issues in Pregnancy
- Histone Deacetylase Inhibitors Research
- Diet and metabolism studies
University of California Davis Medical Center
2015-2024
University of California, Davis
2014-2024
Scripps Memorial Hospital
2022
David Grant USAF Medical Center
2016-2022
Fairfield Hospital
2022
California State University, Sacramento
2022
University of Michigan
2019-2021
United States Air Force
2017-2021
Michigan Medicine
2020-2021
Northwestern University
2020
BACKGROUND: Complete resuscitative endovascular balloon occlusion of the aorta (C-REBOA) increases proximal mean arterial pressure (MAP) at cost distal organ ischemia, limiting duration intervention. We hypothesized that partial aortic (P-REBOA) would maintain a more physiologic MAP and reduce tissue ischemia. investigated hemodynamic effects P-REBOA vs C-REBOA. STUDY DESIGN: Fifteen swine were anesthetized, instrumented, splenectomized, subjected to rapid 25% blood volume loss. They...
Combat-injured patients may require rapid and sustained support during transport; however, the prolonged aortic occlusion produced by conventional resuscitative endovascular balloon of aorta (REBOA) lead to substantial morbidity. Partial REBOA (P-REBOA) permit longer periods allowing some degree distal perfusion. However, ability this procedure limit exsanguination is unclear. We evaluated impact P-REBOA on immediate survival ongoing hemorrhage in a highly lethal swine liver injury...
Peripartum hemorrhage is a significant cause of maternal death. We developed standardized, multidisciplinary cesarean hysterectomy protocol for placenta accreta spectrum (PAS) using prophylactic resuscitative endovascular balloon occlusion the aorta (REBOA). initially placed in proximal zone 3, below renal arteries. An internal review revealed more bleeding than expected, and we subsequently changed our to occlude origin inferior mesenteric artery (distal 3), decrease blood flow through...
Despite clinical reports of poor outcomes, the degree to which resuscitative endovascular balloon occlusion aorta (REBOA) exacerbates traumatic brain injury (TBI) is not known. We hypothesized that combined effects increased proximal mean arterial pressure (pMAP), carotid blood flow (Qcarotid), and intracranial (ICP) from REBOA would lead TBI progression compared with partial aortic (PAO) or no intervention.Twenty-one swine underwent a standardized via computer Controlled cortical impact...
A Rotating Detonation Engine engineered and manufactured by Pratt Whitney Seattle Aerosciences Center was loaned to the Air Force Research Laboratory at WrightPatterson Base for further testing development. The engine originally designed ethylene oxygen, but altered in order use hydrogen air. tested a wide range of flow rates equivalence ratios with hydrogen-air obtain matrix operating space. Although considerable portion test contained successful detonations, all detonations that occurred...
The duration of use and efficacy resuscitative endovascular balloon occlusion the aorta (REBOA) is limited by distal ischemia. We developed a hybrid endovascular-extracorporeal circuit variable aortic control (VAC) device to extend REBOA in lethal model hemorrhagic shock serve as an experimental surrogate further development VAC (EVAC) technologies.Nine Yorkshire-cross swine were anesthetized, instrumented, splenectomized, subjected 30% liver amputation. Following short period uncontrolled...
To avoid potential cardiovascular collapse after resuscitative endovascular balloon occlusion of the aorta (REBOA), current guidelines recommend methodically deflating for 5 minutes to gradually reperfuse distal tissue beds. However, anecdotal evidence suggests that this approach may still result in unpredictable aortic flow rates and hemodynamic instability. We sought characterize dynamics following REBOA as is deflated accordance with practice guidelines.Eight Yorkshire-cross swine were...
Abstract Purpose Microbial infection stimulates neutrophil/macrophage/monocyte extracellular trap formation, which leads to the release of citrullinated histone H3 (CitH3) catalyzed by peptidylarginine deiminase (PAD) 2 and 4. Understanding these molecular mechanisms in pathogenesis septic shock will be an important next step for developing novel diagnostic treatment modalities. We sought determine expression CitH3 patients with shock, correlate levels PAD2/PAD4 clinically relevant outcomes....
BACKGROUND Prolonged Casualty Care (PCC) is a military adaptation of Tactical Combat providing up to 72 hours prehospital care in delayed extrication. However, PCC challenging because recommended medications outweighing size/weight restrictions during dismounted operations. We sought narrow down the medication and supply items required for create standardized effective prolonged field kit (PFAK) with weight limitation 20 lbs. METHODS Joint Trauma Systems Clinical Practice Guidelines were...
BACKGROUND The transition from complete aortic occlusion during resuscitative endovascular balloon of the aorta can be associated with hemodynamic instability. Technique refinements and new technologies have been proposed to minimize this effect. In order inform techniques technology, we examined relationship between blood pressure flow restoration systemic circulation following at progressive levels hemorrhage. METHODS An automated supraceliac clamp, capable continuously variable degrees...
Background Patient selection for resuscitative endovascular balloon occlusion of the aorta (REBOA) has evolved during last decade. A recent multicenter collaboration to implement newest generation REBOA catheter identified variability in patient criteria. The aims this systematic review were compare guidelines and identify current areas consensus variability. Methods In accordance with Preferred Reporting Items Systematic Reviews Meta-Analyses guidelines, we conducted a clinical practice...
Abstract Liquid chromatography mass spectrometry (LC-MS) is shown to provide high discriminating power for the identification of textile dyes that can not be reliably distinguished on basis their UV/visible absorption profile. Seven pairs commercial having nearly identical profiles and maxima within 5 nm, were identified successfully by LC-MS. Two cotton fibers, which indistinguishable microspectrophotometry, differentiated A single wavelength detector was used monitoring dye elution from...
A 28-year-old man with multiple gunshot wounds to the chest and upper extremities was transported by private vehicle a community hospital limited trauma capabilities. On arrival he developed pulseless electrical activity cardiopulmonary resuscitation initiated. He intubated, transfused 4 units of packed red blood cells, resuscitated 2 L crystalloid prior regaining spontaneous circulation. Left-sided tube thoracostomy immediately drained 1600 mL bright blood. transiently stable for short...
Hemorrhage is a leading cause of mortality in trauma. Resuscitative endovascular balloon occlusion the aorta (REBOA) can control hemorrhage, but distal ischemia, subsequent reperfusion injury, and need for frequent titration remain problems. Improved device design allow partial REBOA (pREBOA) that may provide hemorrhage while also perfusing distally without significant provider titration.Female Yorkshire swine (N = 10) were subjected to 40% hemorrhagic shock 1 hour (mean arterial pressure...
Administering antithrombotics (AT) to the multiply injured patient with blunt cerebrovascular injury (BCVI) requires a thoughtful assessment of risk stroke and death associated nontreatment. Large, multicenter analysis outcomes stratified by grade vessel is needed inform future recommendations.Nine hundred seventy-one BCVIs were identified from PROspective Vascular Injury Treatment registry in this retrospective analysis. Using multivariate analysis, we predictors BCVI-related death. We then...
Future endovascular hemorrhage control devices will require features that mitigate the adverse effects of vessel occlusion. Permissive regional hypoperfusion (PRH) with variable aortic (VAC) is a novel strategy to minimize and reduce ischemic burden complete occlusion (AO). The objective this study was compare PRH VAC AO in lethal model hemorrhage.Twenty-five swine underwent cannulation supraceliac aorta, diversion flow through an automated extracorporeal circuit. After creation uncontrolled...
Russo, Rachel M. MD, MAS; Girda, Eugenia MD; Kennedy, Vanessa Humphries, Misty D. MD Author Information