A5035762546- Trauma and Emergency Care Studies
- Respiratory Support and Mechanisms
- Abdominal Trauma and Injuries
- Nitric Oxide and Endothelin Effects
- Cardiac, Anesthesia and Surgical Outcomes
- Pelvic and Acetabular Injuries
- Cardiac Arrest and Resuscitation
- Immune Response and Inflammation
- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Pulmonary Hypertension Research and Treatments
- Sepsis Diagnosis and Treatment
- Parathyroid Disorders and Treatments
- Trauma Management and Diagnosis
- Medical Imaging and Pathology Studies
- Diverticular Disease and Complications
- COVID-19 Clinical Research Studies
- Cardiac Ischemia and Reperfusion
- Cancer Immunotherapy and Biomarkers
- Traumatic Brain Injury and Neurovascular Disturbances
- Hip and Femur Fractures
- Adrenal and Paraganglionic Tumors
- Pancreatic and Hepatic Oncology Research
- Long-Term Effects of COVID-19
- Appendicitis Diagnosis and Management
University of Colorado Anschutz Medical Campus
2002-2024
University of Colorado Denver
2015-2024
University of Edinburgh
2024
Chelsea and Westminster Hospital
2024
University of Colorado Cancer Center
2015-2023
University of Colorado Hospital
1995-2023
University of Colorado Health
2003-2022
Hadassah Medical Center
2022
Valley Hospital
2022
Memorial Hospital
2022
In the past three decades, there has been a significant clinical shift in performance of resuscitative thoracotomy (RT), from nearly obligatory procedure before declaring any trauma patient deceased to more selective application RT. We have sought formulate an evidence-based guideline for current indications RT after injury patient.The Western Trauma Association Critical Decisions Committee queried literature studies defining appropriate role patient. When good data were not available,...
Historically, hemorrhage has been attributed as the leading cause (40%) of early death. However, a rigorous, real-time classification death (COD) not performed. This study sought to prospectively adjudicate and classify COD determine epidemiology trauma mortality.Eighteen centers enrolled all adult patients at time during December 2015 August 2017. Immediately following death, attending providers adjudicated primary contributing secondary using standardized definitions. Data were confirmed...
BACKGROUND: Opioid-related adverse events are a serious problem in hospitalized patients. Little is known about patients who likely to experience opioid-induced respiratory depression on the general care floor and may benefit from improved monitoring early intervention. The trial objective was derive validate risk prediction tool for receiving opioids, as detected by continuous pulse oximetry capnography monitoring. METHODS: PRediction of Opioid-induced Depression In monitored capnoGraphY...
Abstract In addition to stimulating IFN-γ synthesis, IL-18 also possesses inflammatory effects by inducing synthesis of the proinflammatory cytokines TNF and IL-1β chemokines IL-8 macrophage protein-1α. We hypothesized that neutralization would have a beneficial effect in lethal endotoxemia mice. converting enzyme (ICE)-deficient mice, lacking ability process mature IL-1β, were completely resistant induced LPS derived from either Escherichia coli or Salmonella typhimurium. contrast, both...
This is a position article from members of the Western Trauma Association (WTA). Because there are no prospective randomized trials on evaluation and management peripheral vascular trauma, algorithm (Fig. 1) based expert opinion WTA published observational studies. It may not be applicable at all hospitals caring for injured patients. The contains letters that correspond to lettered text intentionally concise. Part I emphasizes evaluation, diagnosis, need operation versus therapeutic...
Five to 10% of patients with differentiated thyroid cancers (DTC) develop invasive and/or distant metastatic disease that is marginally improved standard therapies. Prognosis poor for anaplastic cancer, a median survival 3–5 months. We suggest paradigm shift necessary in the treatment advanced cases. hypothesized T-cell response generated cancer and may be viable therapeutic target. Primary DTCs were analyzed by quantitative RT-PCR (n = 92) expression CD3, CD8, forkhead box (Fox)-P3,...
This is a recommended algorithm of the Western Trauma Association for acute management penetrating chest injury. Because paucity recent prospective randomized trials on evaluation and injury, current algorithms recommendations are based available published cohort, observational retrospective studies, expert opinion members. The two should be reviewed in following sequence: Figure 1 damage-control strategies unstable patient 2 definitive repair stable patient. will discuss techniques; focus...
Context:Recurrent metastatic lymph node (LN) disease is common in patients with papillary thyroid cancer (PTC). Novel prognostic markers may be helpful guiding a therapeutic approach. Our previous studies revealed that immune suppression evident PTC and associated more severe disease.
The global pandemic of COVID-19 has begun to oversaturate the world's medical capacity accommodate a large surge patients with acute respiratory distress syndrome (ARDS).1 Acute no effective treatment besides supportive care, use ventilatory strategies encompassing low tidal volumes that limit transpulmonary pressures being mainstay.2 A consistent finding in ARDS is deposition fibrin airspaces and lung parenchyma, along fibrin-platelet microthrombi pulmonary vasculature, which contribute...
Activation of the nuclear regulatory factor NF-kappaB occurs in lungs patients with acute respiratory distress syndrome (ARDS) and may contribute to increased expression immunoregulatory cytokines other proinflammatory mediators this setting. Because important role that activation appears play development lung injury, we examined cytoplasmic NF-kapppaB counterregulatory mechanisms, involving IkappaB proteins, alveolar macrophages obtained from 7 control without injury 11 established ARDS....
Background: Thoracic aortic injury (TAI) is a devastating condition in which prompt recognition can obviate morbidity and mortality. It long-held belief that TAI more likely when there "major mechanism of injury." The purposes this prospective study were to determine characteristics are predictive evaluate chest computed tomography (CT) as screening tool for TAI. Methods: Over 5 1/2 year period, blunt trauma patients at two Level I centers evaluated potential Patients assigned radiograph...
Toll-like receptor 4 (TLR-4), initially identified as an LPS receptor, is critical to the signaling of a variety danger signals, including heat shock protein 60, fibrinogen, and fibronectin. Recent data also suggest that TLR-4 plays role in determining survival both endotoxemia hemorrhagic shock. We hypothesized functional would be required for hemorrhage endotoxin-induced acute lung injury. Hemorrhage- TNF-alpha mRNA production, neutrophil accumulation, permeability were dependent on TLR-4....
The operative management of mangled extremities after trauma remains controversial. We have sought to develop an evidence-based algorithm help guide practitioners when faced with these relatively infrequent but very challenging clinical dilemmas.The Western Trauma Association Critical Decisions Committee queried the literature identify high-quality managements that would care extremities. When good data were not available, relied on expert opinions, either from or our senior...
Regional metastatic differentiated thyroid cancer (mDTC) provides a unique model in which to study the tumor-immune interface. These lymph node metastases persist for years, generally without progression distant metastases. Although immune system likely impedes disease progression, it is unsuccessful eliminating disease. Our previous studies revealed that programmed death-1 (PD-1)(+) T cells were enriched tumor-involved nodes (TILN). Tumor-associated leukocytes and tumor collected from...
Pulmonary vascular microthrombi are a proposed mechanism of COVID-19 respiratory failure. We hypothesized that early administration tissue plasminogen activator (tPA) followed by therapeutic heparin would improve pulmonary function in these patients.