A5064949001- Cardiac Fibrosis and Remodeling
- Diabetes Treatment and Management
- Diabetes Management and Research
- Cardiac Structural Anomalies and Repair
- Chronic Disease Management Strategies
- Tissue Engineering and Regenerative Medicine
- Medication Adherence and Compliance
- Peptidase Inhibition and Analysis
- Retinoids in leukemia and cellular processes
- Signaling Pathways in Disease
- Cardiovascular Function and Risk Factors
- Immune cells in cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Protease and Inhibitor Mechanisms
- Mobile Health and mHealth Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmaceutical Practices and Patient Outcomes
- Congenital heart defects research
- Immune Response and Inflammation
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac Valve Diseases and Treatments
- Blood Pressure and Hypertension Studies
- Diabetes Management and Education
MSD (Spain)
2019-2022
Spanish National Centre for Cardiovascular Research
2013-2020
National Research Council
2017
National Academies of Sciences, Engineering, and Medicine
2017
Inserm
2017
Humanitas University
2017
Aix-Marseille Université
2017
University of California, San Diego
2014
Activation and accumulation of cardiac fibroblasts, which result in excessive extracellular matrix deposition consequent mechanical stiffness, myocyte uncoupling, ischemia, are key contributors to heart failure progression. Recently, endothelial-to-mesenchymal transition (EndoMT) the recruitment circulating hematopoietic progenitors have been reported generate substantial numbers fibroblasts response pressure overload–induced injury; therefore, these processes widely considered be promising...
The retinoid X receptor α (RXRα) plays a central role in the regulation of many intracellular signaling pathways and can mediate ligand-dependent transcription by forming homodimers or heterodimers with other nuclear receptors. Although several members hormone superfamily have emerged as important regulators macrophage gene expression, existence vivo an RXR pathway macrophages has not been established. Here, we provide evidence that RXRα regulates chemokines Ccl6 Ccl9 independently...
To evaluate the prevalence and coprevalence of several chronic conditions in patients with type 2 diabetes a Mediterranean region.A cross-sectional study.Two hundred eighty-six primary care teams Catalonian Health Institute (Catalonia, Spain).We included aged ≥18 years diagnosis by 31 December, 2016, who were registered Information System for Development Research (SIDIAP) database. We excluded 1 diabetes, gestational mellitus any other diabetes.We collected data on diabetes-related...
Rationale: Myocardial infarction is a major cause of adult mortality worldwide. The origin(s) cardiac fibroblasts that constitute the postinfarct scar remain controversial, in particular potential contribution bone marrow lineages to activated within scar. Objective: aim this study was establish infarct using lineage tracing and transplants robust marker for fibroblasts, Collagen1a1-green fluorescent protein reporter. Methods Results: Using genetic or transplant, we found no evidence...
Macrophage plasticity has been studied in vitro, but transcriptional regulation upon injury is poorly understood. We generated a valuable dataset that captures changes the healthy heart and after myocardial injury, revealing dynamic landscape of macrophage activation. Partial deconvolution suggested post-injury macrophages exhibit overlapping activation pro-inflammatory anti-inflammatory programs rather than aligning to canonical M1/M2 programs. Furthermore, simulated dynamics experimental...
Macrophages (Mφs) produce factors that participate in cardiac repair and remodeling after myocardial infarction (MI); however, how these crosstalk with other cell types mediating is not fully understood. Here we demonstrated Mφs increased the expression of Mmp14 (MT1-MMP) 7 days post-MI. We selectively inactivated gene using a genetic strategy ( f/f : Lyz2 -Cre). This conditional KO (MAC-Mmp14 KO) resulted attenuated post-MI dysfunction, reduced fibrosis, preserved capillary network....
Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent condition worldwide, with significant regional variability in prevalence estimates. This study aimed to determine the prevalence, demographic characteristics, and economic burden of MASLD, metabolic (MASL), steatohepatitis (MASH) Valencian Community region Spain. Methods: We conducted retrospective analysis electronic medical records from public healthcare database individuals aged over 24...
Diabetes is a major health care problem, reaching epidemic numbers worldwide. Reducing hemoglobin A1c (HbA1c) levels to recommended targets associated with marked decrease in the risk of type 2 diabetes mellitus (T2DM)-related complications. The implementation new technologies, particularly telemedicine, may be helpful facilitate self-care and empower people T2DM, leading improved metabolic control disease.This study aimed analyze effect home digital patient empowerment communication tool...
Studies on treatment adherence to glucose-lowering drugs among patients with type 2 diabetes (T2D) including concomitant for other cardiovascular risk factors are scarce. We aimed estimate the prevalence of good all medications used control diabetes, hypertension and dyslipidemia analyse cardiometabolic its associated in T2D primary care (PC) setting.Observational, retrospective study conducted adult who were followed PC setting Spain. Patients classified as adherent a particular category if...
Aim: To assess the potential risk of overtreatment in patients with type 2 diabetes (T2DM) aged 75 years or older primary care. Methods: Electronic health records retrieved from SIDIAP database (Catalonia, Spain) 2016. Variables: age, gender, body mass index, registered hypoglycemia, last HbA1c and glomerular filtration rates, prescriptions for antidiabetic drugs. Potential was defined as having < 7% 6.5% treated insulin, sulfonylureas, glinides. Results: From a total population 138,374 T2DM...
ABSTRACT Macrophages produce factors that participate in cardiac repair and remodeling after myocardial infarction (MI); however, how these crosstalk with other cell types mediating is not fully understood. In this study, we demonstrated macrophages increased expression of Mmp14 (MT1-MMP) 7 days post-MI. Specific macrophage-targeting MT1-MMP (MT1-MMP ΔLysM mice) attenuates post-MI dysfunction, reduces fibrosis, preserves the capillary network. Mechanistically, showed activates latent TGFβ1...
Objective: T2DM patients often have multiple comorbidities which may impact patients’ management approach and treatment selection. This is the first study examining co-prevalence of such as CVD CKD (GFR &lt;60 ml/min and/or UACR ≥ 30 mg/g) across in Spain using a well-validated local database (DB). Methods: Retrospective cross-sectional Spanish electronic records DB “Information System for Development Research Primary Care”, SIDIAP. Adult with were included comorbid conditions assessed...
Objective: To estimate the CKD (GFR &lt;60 ml/min and/or UACR ≥ 30 mg/g) prevalence among T2DM patients and evaluate use of antidiabetic drugs based on renal function. Methods: Retrospective, cross-sectional study, analyzing data from Spanish electronic records database “Information System for Development Research in Primary Care, SIDIAP”, Jan, 2015 to Dec, 2016. The each stage chronic failure (CRF; GFR&lt;60 mL/min) was evaluated with available GFR. Furthermore, adjusted RR 5 events...
<sec> <title>BACKGROUND</title> Diabetes is a major health care problem, reaching epidemic numbers worldwide. Reducing glycated hemoglobin (HbA1c) levels to recommended targets associated with marked decrease in the risk of T2DM-related complications. The implementation new technologies, particularly telemedicine, may be helpful facilitate self-care and empowerment people T2DM leading an improved metabolic control disease. </sec> <title>OBJECTIVE</title> To analyze effect home digital...