A5037910869- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Alcohol Consumption and Health Effects
- Inflammatory Bowel Disease
- Liver Diseases and Immunity
- Microscopic Colitis
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Diverticular Disease and Complications
- Bariatric Surgery and Outcomes
- Biliary and Gastrointestinal Fistulas
- Pancreatitis Pathology and Treatment
- Pregnancy and Medication Impact
- Endoplasmic Reticulum Stress and Disease
- Medical research and treatments
- Fungal Infections and Studies
- Celiac Disease Research and Management
- Biosimilars and Bioanalytical Methods
- Folate and B Vitamins Research
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
- Alcoholism and Thiamine Deficiency
- Gallbladder and Bile Duct Disorders
INCLIVA Health Research Institute
2020-2025
Hospital Clínico Universitario de Valencia
2017-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2025
Center for Digestive and Liver Diseases
2024
Hospital General Universitario Gregorio Marañón
2024
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2024
Instituto de Salud Carlos III
2020-2024
University of Pittsburgh Medical Center
2022-2024
Universitat de València
2017-2023
Leitat Technological Center
2023
Background Standardized manual region of interest (ROI) sampling strategies for hepatic MRI steatosis and iron quantification are time consuming, with variable results. Purpose To evaluate the performance automatic whole-liver segmentation (WLS) proton density fat fraction (PDFF) estimation (transverse relaxometry [R2*]) versus ROI, liver biopsy as reference standard. Materials Methods This prospective, cross-sectional, multicenter study recruited participants chronic disease who underwent...
Abstract Background/Aims Bariatric surgery can increase the risk of addictive disorders and nutritional deficiencies. The aim this study was to evaluate association between bariatric alcohol use disorder (AUD), alcohol-related liver disease (ALD), psychiatric associated with AUD. impact vitamin D deficiency in these associations also investigated. Methods A cross-sectional performed using National Inpatient Sample database its ICD-9 codes information. Diagnostic comorbidity data from...
Early forms of alcohol-associated liver disease (ALD) include different stages in the progression compensated ranging from steatosis to steatohepatitis and fibrosis. ALD has been classically diagnosed at advanced more frequently than other diseases. This fact probably contributed scarcity studies on early ALD. Recent have investigated prevalence general population described natural history alcohol-induced fibrosis, which linked worse prognosis compared chronic In addition, screening...
Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent condition worldwide, with significant regional variability in prevalence estimates. This study aimed to determine the prevalence, demographic characteristics, and economic burden of MASLD, metabolic (MASL), steatohepatitis (MASH) Valencian Community region Spain. Methods: We conducted retrospective analysis electronic medical records from public healthcare database individuals aged over 24...
The prevalence and impact of alcohol withdrawal syndrome (AWS) in patients with alcohol-associated hepatitis (AH) are unknown. In this study, we aimed to investigate the prevalence, predictors, management, clinical AWS hospitalized AH.A multinational, retrospective cohort study enrolling AH at 5 medical centres Spain USA was performed between January 1st, 2016 31st, 2021. Data were retrospectively retrieved from electronic health records. Diagnosis based on criteria use sedatives control...
Histological evaluation of metabolic-associated fatty liver disease (MAFLD) biopsies is subjective, descriptive and with interobserver variability.To examine the relationship between different histological features (fibrosis, steatosis, inflammation iron) measured automated whole-slide quantitative digital pathology corresponding semiquantitative scoring systems, distribution measurements across Fatty Liver Inhibition Progression (FLIP) algorithm Steatosis, Activity Fibrosis (SAF) system...
Patients with nonalcoholic fatty liver disease (NAFLD) may show mild cognitive impairment (MCI). The neurological functions affected remain unclear. aims were to: (1) Characterize the neuropsychological alterations in NAFLD patients; (2) assess prevalence of evaluated; (3) develop a new score for sensitive and rapid MCI detection NAFLD; (4) differences features between patients (NAFL) steatohepatitis (NASH); (5) compare cirrhotic MCI. Fifty-nine 53 controls performed psychometric tests...
ATP citrate lyase (ACLY) inhibitors have the potential of modulating central processes in protein, carbohydrate, and lipid metabolism, which can relevant physiological consequences aging age-related diseases. Here, we show that hepatic phospho-active ACLY correlates with overweight Model for End-stage Liver Disease score humans. Wild-type mice treated chronically inhibitor potassium hydroxycitrate exhibited delayed early mortality. In AML12 hepatocyte cultures, hydroxycitrate, SB-204990,...
Background and Aims: Alcohol use disorder has been reported in patients undergoing bariatric procedures, but the pattern of alcohol consumption not evaluated. We investigated prevalence, risk factors, impact binge drinking (BD) at time surgery during follow-up. Methods: A prospective, longitudinal study subjects was included LABS-2 registry between 2006 2009. Participants with AUDIT questionnaire a minimum 12 months follow-up were included. BD defined as consuming ≥5 drinks on least 1...
Abstract Golimumab has demonstrated its long-term efficacy and safety in ulcerative colitis clinical trials, but no data of persistence been published from real world. To estimate golimumab, as well factors associated with longer persistence, patients life. Observational multicentre study including adult treated golimumab at least twelve months follow-up. We included 190 patients, 105 (55.26%) naive to anti-TNF, mean disease duration 9.32 ± 8.09 years. Probability was 63%, 46%, 39% 27% 1, 2,...
Knowing patients' ulcerative colitis history is essential to selecting the appropriate therapy according risk stratification.
Alcohol relapse after surviving an episode of alcohol-associated hepatitis (AH) is common. However, the clinical features, risk factors, and prognostic implications recurrent (RAH) are not well described.