A5073861428- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Synthetic Organic Chemistry Methods
- Bioactive Compounds and Antitumor Agents
- Chemical Synthesis and Analysis
- Chemical Synthesis and Reactions
- Multicomponent Synthesis of Heterocycles
- Plant biochemistry and biosynthesis
- Sulfur-Based Synthesis Techniques
- Traditional and Medicinal Uses of Annonaceae
- Allelopathy and phytotoxic interactions
- Marine Sponges and Natural Products
- Phytochemical Studies and Bioactivities
- Chromatography in Natural Products
- Chemical synthesis and alkaloids
- Oxidative Organic Chemistry Reactions
- Asymmetric Synthesis and Catalysis
Université Paris-Saclay
2016-2018
Centre National de la Recherche Scientifique
2012-2018
Institut de Chimie des Substances Naturelles
2012-2018
University of Pennsylvania
2017
Université Paris-Sud
2015-2016
Under oxidative conditions, 1,4-dihydropyridines (DHPs) undergo a homolytic cleavage, forming exclusively Csp3-centered radical that can engage in the C-H alkylation of heterocyclic bases and 1,4-quinones. DHPs are readily prepared from aldehydes, considering aldehydes normally require harsh reaction conditions to take part such transformations, with mixtures alkylated acylated products often being obtained, this net decarbonylative approach becomes particularly useful. The present method...
A protocol for the aminomethylation of aryl halides using α-silylamines via Ni/photoredox dual catalysis is described. The low oxidation potential these silylated species enables facile single electron transfer (SET) amine followed by rapid desilylation. resulting α-amino radicals can be directly funneled into a nickel-mediated cross-coupling cycle with halides. process accomplishes under remarkably mild conditions and tolerates numerous aryl- heteroaryl an array functional groups.
The synthesis of one the most potent dual inhibitors anti-apoptotic proteins Bcl-xL and Mcl-1 is reported. This analogue a natural sesquiterpenoid dimer meiogynin A was elaborated by convergent asymmetric with 36% yield in ten steps.
The synthesis, on a large scale, with very good yield and er <italic>via</italic> an efficient strategy, of chiral 4-substituted 2-cyclohexenone intermediate, was milestone in the synthesis seven analogues meiogynin A, natural sesquiterpenoid dimer.
Eleven analogs of the natural product meiogynin A, an inhibitor proteins Bcl‐2 family, have been elaborated by intermolecular Diels–Alder (DA) reaction various conjugated chloro‐trienes, in order to determine influence modification south part A on its biological activity. The chloro‐trienes were obtained two five steps from commercial compounds through a selective hydrochlorination bromoalkyne intermediates ( Z )‐1,2‐dihalogenated alkenes followed chemoselective Suzuki–Miyaura...
Iridoid glycosides possess highly functionalised monoterpenoid aglycon with several contiguous stereocentres. For the most common, they are often present in quantities reaching percentage of fresh plant weight, and thus may be regarded as starting material for synthesis a number new chiral bioactive molecules.To quantify to isolate 8-O-acetylharpagide (AH) from extracts Oxera coronata R.P.J. de Kok, Lamiaceae species endemic New Caledonia, using HPLC-ELSD (evaporative light scattering...
Aliphatic and aromatic esters are efficiently transformed into amides in good to excellent yields, under mild conditions using methylaluminoxane (MAO). This reaction can be performed either at room temperature or by applying microwave irradiation.
Iridoid glycosides, which form a large group of cyclopentane monoterpenoids, are biosynthesized by number plant species belonging to approximately 20 important botanical families. They possess highly functionalized aglycon, may be regarded as starting material for the synthesis new chiral molecules. For this study, 500 were selected from iridoid-containing A methodology, based on combination different analytical and spectroscopic techniques such LC/UV/DEDL, LC/MS NMR, was developed in order...
Abstract The reaction is performed starting from alkanoates, alkenoates, and benzoates with the corresponding methyl carboxylates providing highest product yields.