Ibrahim Alhabli
A5090460265- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Cerebral Venous Sinus Thrombosis
- Cardiac, Anesthesia and Surgical Outcomes
- Brain Tumor Detection and Classification
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Colorectal Cancer Surgical Treatments
- Intracranial Aneurysms: Treatment and Complications
- Congenital Heart Disease Studies
- Vagus Nerve Stimulation Research
- S100 Proteins and Annexins
- Appendicitis Diagnosis and Management
- Diverticular Disease and Complications
- Renal and Vascular Pathologies
- Intravenous Infusion Technology and Safety
- Cardiovascular Health and Disease Prevention
- Advanced X-ray and CT Imaging
- Surgical site infection prevention
- Organ Donation and Transplantation
- Diabetic Foot Ulcer Assessment and Management
- Uterine Myomas and Treatments
- Global Health Workforce Issues
University of Calgary
2022-2025
University of Edinburgh
2024
University of Göttingen
2022
University of Birmingham
2022
National Institute for Health Research
2022
King Abdulaziz Medical City
2018
Emerging data suggest that direct oral anticoagulants may be a suitable choice for anticoagulation cerebral venous thrombosis (CVT). However, conducting high-quality trials in CVT is challenging as it rare disease with low rates of adverse outcomes such major bleeding and functional dependence. To facilitate the design future trials, SECRET (Study Rivaroxaban Cerebral Venous Thrombosis) assessed (1) feasibility recruitment, (2) safety rivaroxaban compared standard-of-care anticoagulation,...
It is unknown whether intravenous thrombolysis using tenecteplase noninferior or preferable compared with alteplase for patients acute ischemic stroke.
Background and Purpose Successful complete reperfusion should be the aim of every endovascular thrombectomy (EVT) procedure. However, effect time delays on successful in late window stroke patients presenting 6-to-24 h from onset has not been investigated. Materials Methods We pooled individual patient-level data seven trials registries for anterior circulation treated with EVT between 6 24 onset. explored impact across multiple interval times, including to hospital arrival; arrival arterial...
Background: Rapid, accurate diagnosis and characterization of carotid atherosclerosis can help prevent disabling strokes. Although plaques be identified on CT angiography (CTA), interpretation is challenging for frontline physicians. Quantification plaque volume/composition requires much manual effort. We developed tested a fully automated tool segmenting lumens delineating atherosclerotic plaque, distinguishing between calcific hypodense components. Methods: used 528 consecutive cases with...
Background and Objectives: Emerging literature suggests that non-stenotic carotid disease (<50% stenosis), especially in the presence of high-risk plaque features, can be a possible etiology for ischemic stroke. We aimed to evaluate odds concordant stroke among individuals with arteries various features. Methods: This is secondary analysis from Alteplase compared Tenecteplase (AcT) trial. evaluated on baseline CT Angiogram (CTA) assess degree stenosis, features such as ulceration,...
Background and Aims: Machine learning models have shown promising potential for automated hemorrhage detection segmentation, alleviating highly time-consuming manual contouring facilitating rapid clinical diagnosis. External validation is essential to assess model generalizability performance across new dataset configurations. To this end, we externally validated a novel segmentation in an unseen randomized-controlled trial dataset. Methods: A architecture based on denoising diffusion...
The Carotid web (CaW) is a cause of stroke, particularly in younger individuals. However, the frequency and radiological features web's morphology associated with stroke risk are uncertain. We determined CaW on computed tomography (CT) angiography ipsilateral stroke.
Background: Carotid tandem lesions ((TL) ⩾70% stenosis or occlusion) account for 15–20% of acute stroke with large vessel occlusion. Aims: We investigated the safety and efficacy intravenous tenecteplase (0.25 mg/kg) versus alteplase (0.9 in patients carotid TL. Methods: This is a substudy compared trial. Patients extracranial internal artery (ICA) concomitant occlusion intracranial ICA, M1 M2 segments middle cerebral on baseline computed tomography angiography (CTA) were included. Primary...
BACKGROUND: Early ischemic change and collateral extent are colinear with core volume (ICV). We investigated the relationship between a combined score using Alberta Stroke Program Computed Tomography Score multiphase computed tomography angiography (mCTA) extent, named mCTA-ACE score, on functional outcomes in endovascular therapy–treated patients. METHODS: performed post hoc analysis of subset patients from Alteplase Compared to Tenecteplase trial which was conducted December 2019 January...
Background Carotid web (CaW) is a risk factor for ischemic stroke, mainly in young patients with stroke of undetermined etiology. Its detection challenging, especially among non-experienced physicians. Methods We included CaW from six international trials and registries acute stroke. Identification manual segmentations were performed by three trained radiologists. designed two-stage segmentation strategy based on convolutional neural network (CNN). At the first stage, two carotid arteries...
Background Patients with white matter disease (WMD) – a key marker of cerebral small vessel may have less brain reserve to cope ischemic injury. The relationship WMD functional recovery after endovascular thrombectomy is uncertain. We aim explore the association between and outcome, assessed at multiple time‐points postendovascular thrombectomy. Methods In this post hoc analysis, we analyzed noncontrast computed tomography‐imaging from ESCAPE‐NA1 (Safety Efficacy Nerinetide [NA‐1] in...
BACKGROUND: Recent evidence from thrombolysis trials indicates the noninferiority of intravenous tenecteplase to alteplase with respect good functional outcomes in patients acute stroke. We examined whether health-related quality life (HRQOL) stroke differs by type treatment received. In addition, we association between modified Rankin Scale score 0 1 and HRQOL patient-reported return prebaseline functioning at 90 days. METHODS: Data were all included AcT trial (Alteplase Compared...
Background In ischaemic stroke, minor deficits (National Institutes of Health Stroke Scale (NIHSS) ≤5) at presentation are common but often progress, leaving patients with significant disability. We compared the efficacy and safety intravenous thrombolysis tenecteplase versus alteplase in who had a stroke enrolled Alteplase Compared to Tenecteplase Patients With Acute Ischemic (AcT) trial. Methods The AcT trial included individuals aged >18 years, were eligible for standard-of-care...
Background and Purpose The safety efficacy of tenecteplase in patients with ischemic stroke due to medium vessel occlusion (MeVO) are not well studied. We aimed compare alteplase MeVO.Methods Patients baseline M2-middle cerebral artery (MCA), M3/M4-MCA, P2/P3/P4-posterior (PCA), A2/A3/A4-anterior (ACA) occlusions from the Alteplase Compared Tenecteplase (AcT) trial were included. Primary outcome was proportion 90-day modified Rankin Scale (mRS) 0–1. Secondary outcomes mRS 0–2, ordinal mRS,...
Early ischemic changes on baseline imaging are commonly evaluated for acute stroke decision-making and prognostication.
Background We recently developed a novel machine learning‐based algorithm using multiphase computed tomography angiography (mCTA) to generate perfusion maps of the brain, similar (CTP) (ie, CTA [mCTAp]). Here, we aim validate clinical utility mCTAp in detection brain ischemia and its side, extent, location. Methods In this prospective multi‐reader‐multi‐case analysis, included baseline images: ( StrokeSENS ‐algorithm) CTP (4D; GE Healthcare) from 121 randomly selected patients whose scans...
Background: NCCT is the most widely used parenchymal imaging for acute stroke. Evaluations of brain frailty measures like atrophy and white matter disease (WMD) are becoming increasingly relevant in stroke outcome prediction but conventionally thought to be best seen on MRI. We assessed agreement between baseline follow-up MRI ratings WMD compared their predictive validity relation 90-day functional outcomes ischemic Methods: In this post-hoc analysis data from Alteplase Tenecteplase (AcT)...
To evaluate the reliability and accuracy of nonaneurysmal perimesencephalic subarachnoid hemorrhage (NAPSAH) on Noncontrast Head CT (NCCT) between numerous raters. 45 NCCT adult patients with SAH who also had a catheter angiography (CA) were independently evaluated by 48 diverse raters; raters performed second assessment one month later. For each case, asked: 1) whether they judged bleeding pattern to be perimesencephalic; 2) there was blood anterior brainstem; 3) complete filling...
Introduction: We recently published a Machine Learning-based algorithm using mCTA (mCTAp) that generates perfusion maps of the brain, similar to CTP. Here, we aim validate clinical utility mCTAp in detection ischemia, it’s side, extent and location. Methods: One hundred twenty-one subjects were included test dataset. These had completed (StrokeSENS) CTP (4D; GE Healthcare) at baseline. After excluding 2/121 due poor image quality, multi-reader-multi-case (n=119) study design was conducted...
<b><i>Introduction:</i></b> The aim of the study was to investigate impact time interval between start intravenous thrombolysis (IVT) endovascular thrombectomy (EVT) on stroke outcomes. <b><i>Methods:</i></b> Data from Quality Improvement and Clinical Research (QuICR) provincial registry Alberta, Canada, were used identify patients who received IVT EVT January 2015 December 2019. We assessed bolus puncture (needle-to-puncture times [NPT])...
<h3>Introduction</h3> A recently developed multiphase-computed-tomography-angiography(mCTA) tool generates perfusion maps, similar to CT-perfusion(CTP) (i.e., mCTA-perfusion[mCTAp]). <h3>Aim of Study</h3> To validate the clinical utility mCTAp. <h3>Methods</h3> In this multi-reader-multi-case analysis, we included baseline images: mCTAp(<i>StrokeSENS</i>-algorithm) and CTP(4D; GE-Healthcare) from 121 randomly selected patients whose scans were not part algorithm-development. After excluding...