A5046544003- Acute Ischemic Stroke Management
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare Policy and Management
- Childhood Cancer Survivors' Quality of Life
- Chronic Disease Management Strategies
- Pharmacological Effects and Toxicity Studies
- Stroke Rehabilitation and Recovery
- Bipolar Disorder and Treatment
- Venous Thromboembolism Diagnosis and Management
- Child and Adolescent Psychosocial and Emotional Development
- Geriatric Care and Nursing Homes
- Emergency and Acute Care Studies
- Epilepsy research and treatment
- Pharmaceutical studies and practices
- Healthcare Systems and Practices
- Infant Development and Preterm Care
University of Calgary
2023-2024
Alberta Health Services
2023
BACKGROUND: Recent evidence from thrombolysis trials indicates the noninferiority of intravenous tenecteplase to alteplase with respect good functional outcomes in patients acute stroke. We examined whether health-related quality life (HRQOL) stroke differs by type treatment received. In addition, we association between modified Rankin Scale score 0 1 and HRQOL patient-reported return prebaseline functioning at 90 days. METHODS: Data were all included AcT trial (Alteplase Compared...
Abstract Background A substantial proportion of children have a physical illness; these commonly experience physical–mental comorbidity. To assess child mental health, brief scales that can be used in clinical and research settings are needed. This study assessed the validity reliability parent‐reported Ontario Child Health Study Emotional Behavioural Scale‐Brief Version (OCHS‐EBS‐B) scores. Methods Data come from longitudinal aged 2–16 years with illness recruited outpatient clinics at...
Abstract Objective Health state utilities are required to obtain quality adjusted life years, a common metric that informs clinical decision‐making at individual, group, and health policy levels. different from health‐related of life, their distribution across patients with epilepsy, as well the factors impact them, have not been studied in depth. We aimed describe people epilepsy combinations demographic on evaluation. Methods performed retrospective analysis patients' data prospectively...
Introduction: Utility-weighted mRS (UW-mRS) is increasingly being adopted as an important clinical endpoint in stroke trials it offers some gains statistical efficiency and power when estimating treatment effects. The widely used utility weights for UW-mRS, derived from a systematic review of acute trials, are prone to substantial variability across between categories. This study aims derive UW-mRS by directly mapping 5-item EuroQoL (EQ-5D-5L) responses scores. Methods: Data were collected...
Background and aims: Recent evidence from thrombolysis trials indicate the non-inferiority of Tenecteplase (TNK) to Alteplase (TPA) with respect functional outcomes in acute stroke patients. This study examines predictors patient-reported health-related quality life (HRQOL) patients who received therapy. Methods: Data were used all included AcT, a pragmatic, registry-linked randomized trial comparing TNK TPA. HRQOL at 90-day post-randomization was assessed using EuroQol-5D-5L (EQ-5D) visual...