George Medvedev
A5056588732- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- EEG and Brain-Computer Interfaces
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Reproductive Physiology in Livestock
- Functional Brain Connectivity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Time Series Analysis and Forecasting
- Cerebral Venous Sinus Thrombosis
- Genetic and phenotypic traits in livestock
- Advanced MRI Techniques and Applications
- Health Systems, Economic Evaluations, Quality of Life
- Animal health and immunology
- Moyamoya disease diagnosis and treatment
- Plant and fungal interactions
- Botulinum Toxin and Related Neurological Disorders
- Agricultural Productivity and Crop Improvement
- Neurobiology of Language and Bilingualism
- Cardiovascular and Diving-Related Complications
- Renal Diseases and Glomerulopathies
- ECG Monitoring and Analysis
- Pharmaceutical Practices and Patient Outcomes
- Cardiac Arrest and Resuscitation
Royal Columbian Hospital
2018-2025
University of British Columbia
2002-2025
Fraser Health
2020-2024
Vancouver Biotech (Canada)
2024
Ukrainian Catholic University
2022
Simon Fraser University
2022
National Research Council Canada
2022
Neuroscience Institute
2022
Surrey Memorial Hospital
2018
St. Paul's Hospital
2002
Emerging data suggest that direct oral anticoagulants may be a suitable choice for anticoagulation cerebral venous thrombosis (CVT). However, conducting high-quality trials in CVT is challenging as it rare disease with low rates of adverse outcomes such major bleeding and functional dependence. To facilitate the design future trials, SECRET (Study Rivaroxaban Cerebral Venous Thrombosis) assessed (1) feasibility recruitment, (2) safety rivaroxaban compared standard-of-care anticoagulation,...
It is unknown whether intravenous thrombolysis using tenecteplase noninferior or preferable compared with alteplase for patients acute ischemic stroke.
Abstract This project aimed to develop and evaluate a fast fully-automated deep-learning method applying convolutional neural networks with deep supervision (CNN-DS) for accurate hematoma segmentation volume quantification in computed tomography (CT) scans. Non-contrast whole-head CT scans of 55 patients hemorrhagic stroke were used. Individual standardized 64 axial slices 128 × voxels. Each voxel was annotated independently by experienced raters, generating binary label versus normal brain...
Background: Cryptogenic strokes account for approximately 30-40% of all stroke cases, underscoring the critical need effective identification right-to-left shunt (RLS) and PFO. The recently published BUBL Study (NCT04604015), a multicenter, prospective trial, demonstrated 3-fold increase in detection RLS/PFO using raTCD compared TTE. Wechsler recognized study's important findings an accompanying editorial, while also highlighting further validation through additional studies. This study aims...
BACKGROUND: Older age has been associated with overall poorer outcomes in acute ischemic stroke. We compared (1) various health-related domains among patients <80 years and ≥80 presenting stroke (2) whether differ between intravenous TNK (tenecteplase) versus alteplase. METHODS: Data are from included AcT (Alteplase Compared to Tenecteplase Patients With Acute Ischemic Stroke), a pragmatic, registry-linked, phase 3 randomized controlled trial comparing Outcomes functional disability (per...
Electroencephalography (EEG) is a non-invasive tool widely used in basic and clinical neuroscience to explore neural states various populations, classifying these EEG recordings fundamental challenge. While machine learning shows promising results long multivariate time series, optimal prediction models feature extraction methods for classification remain elusive. Our study addressed the problem of under framework brain age prediction, applying deep model on series. We hypothesized that...
Background: Carotid tandem lesions ((TL) ⩾70% stenosis or occlusion) account for 15–20% of acute stroke with large vessel occlusion. Aims: We investigated the safety and efficacy intravenous tenecteplase (0.25 mg/kg) versus alteplase (0.9 in patients carotid TL. Methods: This is a substudy compared trial. Patients extracranial internal artery (ICA) concomitant occlusion intracranial ICA, M1 M2 segments middle cerebral on baseline computed tomography angiography (CTA) were included. Primary...
The AcT (Alteplase Compared to Tenecteplase) randomized controlled trial showed that tenecteplase is noninferior alteplase in treating patients with acute ischemic stroke within 4.5 hours of symptom onset. effect time treatment on clinical outcomes well known; however, the nature this relationship yet be described tenecteplase. We assessed whether association thrombolysis differs by they receive intravenous versus alteplase. Patients included were from AcT, a pragmatic, registry-linked,...
Background Intravenous thrombolysis with alteplase is widely used in patients acute ischemic stroke presenting early after symptom onset. Recent phase II trials have suggested that intravenous tenecteplase may be safer and associated higher reperfusion rates as compared alteplase. This study investigates whether noninferior to for the treatment of stroke. Methods a pragmatic, registry‐linked, prospective, randomized (1:1) controlled, open‐label parallel group clinical trial (AcT [Alteplase...
Understanding sex differences in stroke care is important reducing potential disparities. Our objective was to explore workflow efficiency, treatment efficacy, and safety the AcT trial (Alteplase Compared Tenecteplase).
Background : Intravenous thrombolysis with alteplase is widely used in acute ischemic stroke patients presenting early after symptom onset. Recent phase II trials have suggested that intravenous tenecteplase may be safer and associated higher reperfusion rates as compared to alteplase. This study investigates whether non‐inferior for the treatment of stroke. Methods a pragmatic, registry‐linked, prospective, randomized (1:1) controlled, open‐label parallel group clinical trial blinded...
Non-invasive neuromodulation using translingual neurostimulation (TLNS) has been shown to advance rehabilitation outcomes, particularly when paired with physical therapy (PT). Together motor gains, patient-reported observations of incidental improvements in cognitive function have noted. Both studies healthy individuals and case reports clinical populations linked TLNS attention-related processes. We investigated if the use combined TLNS/PT would translate changes objective...
BACKGROUND: Recent evidence from thrombolysis trials indicates the noninferiority of intravenous tenecteplase to alteplase with respect good functional outcomes in patients acute stroke. We examined whether health-related quality life (HRQOL) stroke differs by type treatment received. In addition, we association between modified Rankin Scale score 0 1 and HRQOL patient-reported return prebaseline functioning at 90 days. METHODS: Data were all included AcT trial (Alteplase Compared...
Interhospital transfer for patients with stroke due to large vessel occlusion endovascular thrombectomy (EVT) has been associated treatment delays.
Background: Hemorrhagic transformation after acute ischemic stroke is a dreaded and severe complication of thrombolysis thrombectomy. However, its detection on post-thrombectomy conventional non-contrast computed tomography (CT) scan can be complicated by the frequent (and sometimes concomitant) presence contrast, resulting in changes management. Aims: Our objective was to assess inter- intra-rater reliability for blood and/or contrast day-1 CT scans. Methods: A total 18 raters across 3...
Introduction Haemorrhagic stroke is of significant healthcare concern due to its association with high mortality and lasting impact on the survivors’ quality life. Treatment decisions clinical outcomes depend strongly size, spread location haematoma. Non-contrast CT (NCCT) primary neuroimaging modality for haematoma assessment in haemorrhagic diagnosis. Current procedures do not allow convenient NCCT-based haemorrhage volume calculation settings, while research-based approaches are yet be...
Routine clinical EEG is a standard test used for the neurological evaluation of patients. A trained specialist interprets recordings and classifies them into categories. Given time demands high inter-reader variability, there an opportunity to facilitate process by providing decision support tools that can classify automatically. Classifying associated with several challenges: classification models are expected be interpretable; EEGs vary in duration recorded multiple technicians operating...
Electroencephalography (EEG) is a technique that measures brain activity across the surface using electrodes attached to scalp. The advantages of EEG include its noninvasiveness and cost-effectiveness compared alternatives, like magnetic resonance imaging electrocorticography. analysis has various applications, such as in detecting neurodegenerative diseases (eg. epilepsy) facilitating brain-computer interfaces. In this study, we utilize machine learning explore age prediction based on data....