Philip Teal
A5011832099- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Health and Disease Prevention
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebral Venous Sinus Thrombosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Peripheral Artery Disease Management
- Neurological Disorders and Treatments
- Vestibular and auditory disorders
- Cardiovascular and Diving-Related Complications
- Cardiac Arrhythmias and Treatments
- Cardiac tumors and thrombi
- Lipoproteins and Cardiovascular Health
- Cardiac, Anesthesia and Surgical Outcomes
- Advanced MRI Techniques and Applications
- Ophthalmology and Eye Disorders
- Botulinum Toxin and Related Neurological Disorders
- Cardiac Imaging and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Blood Pressure and Hypertension Studies
University of British Columbia
2014-2025
Vancouver General Hospital
2007-2024
United Nations Economic and Social Commission for Asia and the Pacific
2021-2024
Arcadia
2024
Bournemouth University
2023
University of Nottingham
2007-2022
University Medical Center Utrecht
2017-2021
Utrecht University
2021
Population Health Research Institute
2018
Hamilton Health Sciences
2018
Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared the efficacy and safety of two antiplatelet regimens--aspirin plus extended-release dipyridamole (ASA-ERDP) versus clopidogrel.In this double-blind, 2-by-2 factorial trial, we randomly assigned patients to receive 25 mg aspirin 200 twice daily or 75 clopidogrel daily. The primary outcome was first recurrence secondary composite stroke, myocardial infarction, death from vascular causes. Sequential...
Prolonged lowering of blood pressure after a stroke reduces the risk recurrent stroke. In addition, inhibition renin-angiotensin system in high-risk patients rate subsequent cardiovascular events, including However, effect with inhibitor soon has not been clearly established. We evaluated effects therapy an angiotensin-receptor blocker, telmisartan, initiated early stroke.In multicenter trial involving 20,332 who recently had ischemic stroke, we randomly assigned 10,146 to receive...
Background and Purpose— A previous randomized, placebo-controlled, double-blind study suggested that abciximab may be safe effective in treatment of acute ischemic stroke. The current phase 3 was planned to test the relative efficacy safety patients with stroke within 5 hours since symptoms onset. Methods— An international, trial tested intravenous administration 2 cohorts using stratification variables time onset severity. enrollment 1800 patients. primary cohort enrolled those who could...
Evidence suggests that statin therapy reduces the risk of stroke in patients with coronary heart disease (CHD), but its benefit for cerebrovascular and no history CHD remains uncertain. The Stroke Prevention by Aggressive Reduction Cholesterol Levels (SPARCL) Study is a prospective, multi-centre, double-blind, randomised, placebo-controlled trial designed to evaluate effects atorvastatin 80 mg/day who previously experienced or transient ischaemic attack, have known CHD. A total 4,732 been...
We report 10 patients with severe occlusive disease of the vertebral artery (VA) origin in neck intra-arterial embolism to posterior circulation. The VA lesions seven were complete occlusions, and three had atherostenosis. All strokes vertebrobasilar territory. most frequent recipient sites intracranial VA-posterior inferior cerebellar region (8), distal basilar (BA) its superior cerebral branches (7). Two pontine infarction due BA embolism. common clinical signs infarction. Atherosclerotic...
AbstractAntiplatelet agents are a cornerstone of therapy for patients with atherosclerotic vascular disease. There is presently lack comprehensive guidelines focusing on the use antiplatelet drugs in currently manifesting or at elevated risk cardiovascular The Canadian Antiplatelet Therapy Guidelines Committee reviewed existing disease-based and subsequently published literature used expert opinion review to develop outpatient setting. This full document has been summarized an Executive...
In previous studies, the Totaled Health Risks in Vascular Events (THRIVE) score has shown broad utility, allowing prediction of clinical outcome, death, and risk hemorrhage after tissue-type plasminogen activator (tPA) treatment, irrespective type acute stroke therapy applied to patient. We used data from Virtual International Stroke Trials Archive further validate THRIVE a large cohort patients receiving tPA or no confirm relationship between tPA, compare with several other available...
Emerging data suggest that direct oral anticoagulants may be a suitable choice for anticoagulation cerebral venous thrombosis (CVT). However, conducting high-quality trials in CVT is challenging as it rare disease with low rates of adverse outcomes such major bleeding and functional dependence. To facilitate the design future trials, SECRET (Study Rivaroxaban Cerebral Venous Thrombosis) assessed (1) feasibility recruitment, (2) safety rivaroxaban compared standard-of-care anticoagulation,...
In a double-blind placebo-controlled study, we evaluated the effects of clozapine (75 to 250 mg/day, mean 170.8) on dopaminomimetic psychosis and parkinsonian disability. Clozapine prevented deterioration during increase dopaminomimetics in 3 patients who completed study. Worsening parkinsonism occurred 6 patients. dosage used, clozapine9s usefulness was limited by its propensity produce sedation, confusion, increased parkinsonism.
Stroke has global importance and it causes an increasing amount of human suffering economic burden, but its management is far from optimal. The unsuccessful outcome several research programs highlights the need for reliable data on which to plan future clinical trials. Virtual International Trials Archive aims aid planning trials by collating providing access a rich resource patient perform exploratory analyses.Data were contributed principal investigators numerous past 16 years. These have...
Increased sympathetic drive after stroke is involved in the pathophysiology of several complications including poststroke immunudepression. β-Blocker (BB) therapy has been suggested to have neuroprotective properties and decrease infectious stroke. We aimed examine effects random pre- on-stroke BB exposure on mortality, functional outcome, occurrence pneumonia ischemic stroke.Data standard demographic clinical variables as well prestroke antihypertensive medication, incidence pneumonia,...
<h3>Objective:</h3> To compare the prognostic accuracy of various acute stroke scales using a large, independent, clinical trials dataset. <h3>Methods:</h3> We directly compared 8 scales, chosen based on focused literature review (Acute Stroke Registry and Analysis Lausanne [ASTRAL]; iSCORE; iSCORE-revised; preadmission comorbidities, level consciousness, age, neurologic deficit [PLAN]; subtype, Oxfordshire Community Project, prestroke modified Rankin Scale [mRS] [SOAR]; SOAR; Prognosis...
The occurrence of pneumonia after stroke is associated with a higher risk poor outcome or death. We assessed the temporal profile and its association at several time points to identify most optimal period for testing prevention strategies.We analyzed individual patient data stored in VISTA (Virtual International Stroke Trials Archive) from randomized acute trials an inclusion window up 24 hours onset first 90 days stroke. Adjusted odds ratios hazard were calculated between death by means...
We report the clinical findings and stroke mechanisms of 63 patients with cerebellar infarcts. divided intracranial vertebrobasilar circulation into proximal territory (P), fed by vertebral arteries their branches; middle (M), basilar artery its distal (D), rostral branches. Cerebellar infarcts were classified vascular territories P, M, D, P&D, middle-plus (P&M, M&D, P&M&D). Patients P (11 patients) frequently had vertigo, gait instability, limb ataxia, headache, whereas...
Background and Purpose— Quality of life (QoL) is important to stroke survivors yet often recorded as a secondary measure in acute randomized controlled trials. We examined whether commonly used outcome measures captured aspects QoL. Methods— primary outcomes by National Institutes Health Stroke Scale (NIHSS), Barthel Index (BI) modified Rankin (mRS), QoL Impact (SIS) European Life (EQ-5D) from the Virtual International Trials Archive (VISTA). Using Spearman correlations logistic regression,...
Abstract Objective To validate the previously derived Canadian TIA Score to stratify subsequent stroke risk in a new cohort of emergency department patients with transient ischaemic attack. Design Prospective study. Setting 13 departments over five years. Participants 7607 consecutively enrolled adult attending attack or minor stroke. Main outcome measures The primary was carotid endarterectomy/carotid artery stenting within seven days. secondary days (with without stenting). Telephone...
To assess whether statin treatment before or after acute ischemic stroke (AIS) affects the risk of intracerebral hemorrhage (ICH), postacute ICH, and mortality within 90 days.Data were sought from Virtual International Stroke Trials Archive, an international repository clinical trials data. Using propensity score matching, we retrospectively compared patients with prior newly initiated 3 days AIS to without exposure. Outcomes interest symptomatic ICH (sICH), any during follow-up months.A...