A5004979010- Migraine and Headache Studies
- Acute Ischemic Stroke Management
- Neurological Disorders and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Neuroscience of respiration and sleep
- Neurological Complications and Syndromes
- Maternal Mental Health During Pregnancy and Postpartum
- Trigeminal Neuralgia and Treatments
- Homicide, Infanticide, and Child Abuse
- Cerebral Venous Sinus Thrombosis
- Psychosomatic Disorders and Their Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Suicide and Self-Harm Studies
- Child Abuse and Trauma
- Sympathectomy and Hyperhidrosis Treatments
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Vestibular and auditory disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Ophthalmology and Eye Disorders
- Peripheral Artery Disease Management
- Systemic Lupus Erythematosus Research
- Cardiovascular and Diving-Related Complications
- Olfactory and Sensory Function Studies
University of Toledo
2016-2025
Rush University
2020
Sleep Research Society
2020
University of Toledo Medical Center
2004-2019
New York Psychoanalytic Society and Institute
2019
New York State Psychiatric Institute
2019
NYU Langone Health
2019
Neurology, Inc
2017
Johns Hopkins University
2011-2015
University of California, San Francisco
2015
Background.— A variety of studies have linked childhood maltreatment to headaches, including migraines, and headache severity. This study assesses the relationship adverse experiences (ACEs) frequent headaches during adulthood. Methods.— We used data from Adverse Childhood Experiences (ACE) study, which included 17,337 adult members Kaiser Health Plan in San Diego, CA who were undergoing a comprehensive preventive medical evaluation. The assessed 8 ACEs abuse (emotional, physical, sexual),...
Evidence suggests that statin therapy reduces the risk of stroke in patients with coronary heart disease (CHD), but its benefit for cerebrovascular and no history CHD remains uncertain. The Stroke Prevention by Aggressive Reduction Cholesterol Levels (SPARCL) Study is a prospective, multi-centre, double-blind, randomised, placebo-controlled trial designed to evaluate effects atorvastatin 80 mg/day who previously experienced or transient ischaemic attack, have known CHD. A total 4,732 been...
To examine the prevalence of childhood maltreatment and adult revictimization in migraineurs association with sociodemographic factors, depression anxiety.Population practice-based studies have demonstrated an abuse headache adults, although further details on diagnoses, characteristics, comorbid conditions are lacking. There mounting data suggesting substantial impact early physical mental health.Electronic surveys were completed by patients seeking treatment 11 centers across United States...
There is mounting evidence of endothelial activation and dysfunction in migraine. Our objectives were to determine a population premenopausal women whether markers are associated with migraine.Women (18 50 years) without migraine free from cardiovascular disease evaluated tests coagulation (von Willebrand factor activity, prothrombin fragment), fibrinolysis (tissue-type plasminogen activator antigen), inflammation (high-sensitivity C-reactive protein), oxidative stress (homocysteine, total...
Background.— Cutaneous allodynia (CA) in migraine is a clinical manifestation of central nervous system sensitization. Several chronic pain syndromes and mood disorders are comorbid with migraine. In this study we examine the relationship migraine‐associated CA these conditions. We also evaluate association factors such as demographic profiles, characteristics, smoking status that may have an influence on relationships to mood. Methods.— Data from cross‐sectional multicenter conditions...
( Headache 2010;50:32‐41) Objectives.— To assess in a headache clinic population the relationship of childhood abuse and neglect with migraine characteristics, including type, frequency, disability, allodynia, age onset. Background.— Childhood maltreatment is highly prevalent has been associated recurrent headache. Maltreatment many same risk factors for chronification, depression anxiety, female sex, substance abuse, obesity. Methods.— Electronic surveys were completed by patients seeking...
In a previous study, 0.3 and 0.45 mg/kg of intravenous recombinant tissue plasminogen activator (rt-PA) were safe when combined with eptifibatide 75 mcg/kg bolus 2-hour infusion (0.75 per minute). The Combined Approach to Lysis Utilizing Eptifibatide rt-PA in Acute Ischemic Stroke-Enhanced Regimen (CLEAR-ER) trial sought determine the safety higher-dose regimen establish evidence for phase III trial.CLEAR-ER was multicenter, double-blind, randomized study. stroke patients 0.6 plus (135 at...
The authors report eight pregnant women with acute ischemic stroke treated thrombolysis (rt-PA [recombinant human tissue plasminogen activator] or urokinase). Seven recovered. Two extracranial and two asymptomatic intracranial hemorrhages complicated treatment; one woman died of arterial dissection complicating angiography. Three patients had therapeutic abortions, fetuses were miscarried, babies delivered healthy. Although may be safely thrombolytics, risks benefits to mother fetus must...
( Headache 2010;50:1089‐1099) Background.— In 2006, a US Food and Drug Administration (FDA) alert warned about the potential life‐threatening risk of serotonin syndrome when triptans are used in combination with selective reuptake inhibitors (SSRIs) or serotonin/norepinephrine (SNRIs). This American Society Position Paper further reviews available evidence combining other serotonergic agents. Methods.— Using Sternbach Criteria Hunter Serotonin Toxicity Criteria, 29 cases as basis for FDA...
To evaluate in a headache clinic population the relationship of childhood maltreatment on prevalence pain conditions comorbid with migraine.Childhood is highly prevalent and has been frequently associated recurrent headache. The has, however, subject some debate.Cross-sectional data self-reported physician-diagnosed were electronically collected from persons migraine (diagnosed according to International Classification Headache Disorders-2), seeking treatment clinics at 11 centers across US...
To identify distinct constellations of comorbid disorders occurring in migraineurs, and to examine differences demographics, headache profiles, psychosocial features between the comorbidity constellations.This is a retrospective electronic chart review consecutive new female outpatients diagnosed with migraine (n = 223) using International Classification Headache Disorders (ICHD)-II criteria. Questionnaire collected information on diagnoses, current depression, somatic symptoms, stressors,...
Objective.—To examine the headache characteristics of women with migraine and endometriosis (EM), differences in prevalence comorbid conditions between female migraineurs EM, without EM nonheadache controls. Background.—Migraine are common reproductive age, both influenced by ovarian hormones. The comorbidity is newly recognized, but reasons for association uncertain. Methods.—This a cross‐sectional study outpatients healthy controls conducted at University Toledo Duke 2005 2006. After...
Objectives.— Migraine is a risk factor for stroke in young women. Biomarker studies implicate endothelial activation as possible mechanism. Emerging relationships of childhood adversity with migraine, and inflammation, component activation, suggest that it may play role the migraine–stroke association. Our objective to evaluate relationship between adverse experiences (ACEs), vascular biomarker levels premenopausal Methods.— Vascular metabolic biomarkers from women 18‐50 years, including 125...
Early identification and transfer of patients with acute stroke to a primary or comprehensive center results in favorable outcomes.To describe implementation an emergency medical service (EMS)-driven protocol Lucas County, Ohio.All county EMS personnel (N=464) underwent training the Rapid Arterial oCclusion Evaluation (RACE) score. The RACE Alert (RA) protocol, whereby score ≥5 were taken facility that offered advanced therapy, was implemented July 2015. During 6-month study period, 109 RAs...
<h3>Objective:</h3> To examine the relationship of recalled adverse childhood experiences (ACEs) with migraine and episodic tension-type headache (ETTH). <h3>Methods:</h3> We conducted a cross-sectional analysis ACEs among 2007 American Migraine Prevalence Prevention Study survey respondents ETTH migraine. modeled type using logistic regression adjusting for sociodemographic variables (age, race, sex, income), depression, anxiety, day frequency ordinal proportional odds model....
Anticardiolipin antibodies (aCL) are a risk factor for cerebral ischemia. In migraine, the association is controversial, with widely varying results in different small series. The controversy part may be due to inherent difficulty distinguishing transient focal neurologic events (TFNE) of migraine from TIA. To assess frequency aCL we prospectively evaluated consecutive adults under 60 years age without aura and recent TFNE (<24-hour duration) clinically suggestive either or We concomitantly...
Background and Purpose —The aim of our study was to characterize the patient profile prognostic value associated with high positive IgG (>100 GPL) anticardiolipin antibodies (aCL). Methods —We studied clinical, laboratory, radiological, prospective historical features ischemic cerebrovascular disease in patients >100 GPL titers. From neurology department, 27 consecutive were prospectively identified followed up (mean follow-up time, 34 months). Results mean age cohort 41 years....
Objective.—To discern the effects of depression and anxiety on migraine–obesity relationship. Background.—Migraine obesity are highly prevalent conditions both independently linked to psychiatric conditions, mainly anxiety. Methods.—Data from an ongoing cross‐sectional multicenter study comorbid in clinic patients seeking treatment for headache. The diagnosis migraine was determined by examining physician based International Classification Headache Disorders (ICHD)‐II criteria. Participants...
To assess and contrast the relative frequency of self-reported post-traumatic stress disorder (PTSD) in patients with episodic migraine chronic/ transformed migraine.Several risk factors have been identified as for chronification headache disorders. Childhood abuse has suggested a factor chronic pain adulthood. In addition depression, well several other psychiatric disorders, are co-morbid migraine. Recent data suggest that PTSD may be more common sufferers than general population.This was...
Objective.— To evaluate the relative frequency of posttraumatic stress disorder (PTSD) in episodic migraine (EM) and chronic daily headache (CDH) sufferers impact on headache‐related disability. Background.— Approximately 8% population is estimated to have PTSD. Recent studies suggest a higher PTSD disorders. The association disability has not been examined. Methods.— A prospective study was conducted at 6 centers. assessed using life events checklist checklist, civilian version (PCL‐C). We...