A5025670082- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Brain Tumor Detection and Classification
- Photoacoustic and Ultrasonic Imaging
- Advanced MRI Techniques and Applications
- Optical Imaging and Spectroscopy Techniques
- Advanced X-ray and CT Imaging
- Radiomics and Machine Learning in Medical Imaging
- Stroke Rehabilitation and Recovery
- Medical Imaging and Analysis
- Liver Disease and Transplantation
- Renal function and acid-base balance
- MRI in cancer diagnosis
- Transcranial Magnetic Stimulation Studies
- Advanced Neuroimaging Techniques and Applications
- Heart Rate Variability and Autonomic Control
- Migraine and Headache Studies
- Non-Invasive Vital Sign Monitoring
- Liver Disease Diagnosis and Treatment
University of Calgary
2018-2024
Circle Cardiovascular Imaging
2022-2024
Alberta Children's Hospital
2023
Alberta Children's Hospital Research Institute
2023
Ontario Brain Institute
2018-2019
Foothills Medical Centre
2018
With the rapid increase in new fNIRS users employing commercial software, there is a concern that many studies are biased by suboptimal processing methods. The purpose of this study to provide visual reference showing effects different methods, help inform researchers setting up and evaluating pipeline. We show significant impact pre- post-processing choices stress again how important it combine data from both hemoglobin species order make accurate inferences about activation site.
Concussion, or mild traumatic brain injury (mTBI), accounts for ∼80% of all TBIs across North America. The majority mTBI patients recover within days to weeks; however, 14–36% the time, acute symptoms persist months even years and develop into persistent post-concussion (PPCS). There is a need find biomarkers in with PPCS, improve prognostic ability provide insight pathophysiology underlying chronic symptoms. Recent research has pointed toward impaired network integrity cortical...
Background: Approximately 25% of concussion patients experience persistent post-concussion symptoms (PPCS). Repetitive transcranial magnetic stimulation (rTMS) has been explored as a treatment, and functional near-infrared spectroscopy (fNIRS) may be cost-effective method for assessing response. Objectives: Evaluate rTMS the treatment PPCS introduce fNIRS Methods: Design: Two-patient case study. Setting: Calgary Brain Injury Program. Participants: 47 49 yrs. male, with 1-2 years (headache,...
Background and Aims: Early accurate detection of vessel occlusion is essential for the management acute ischemic stroke (AIS). Current automated tools mostly rely on single-phase CTA (sCTA), which makes it challenging to accurately identify Medium Vessel Occlusions (MeVO). Multiphase (mCTA), consist an additional two low-dose scans traditional workflow, may be able allow precise MeVO occlusions. In this work, we aim validate StrokeSENS mCTA Occlusion Detection in its ability detect LVOs...
Background and Aims Primary biliary cholangitis (PBC) is an autoimmune cholestatic liver disease linked to symptoms including fatigue altered mood/cognition, indicating that chronic inflammation associated with PBC can impact brain function. We employed near‐infrared spectroscopy (NIRS), a noninvasive neuroimaging technique, determine whether patients exhibit reduced cerebral oxygen saturation (StO 2 ) patterns of microvascular blood perfusion these alterations were clinical phenotype. This...
Advanced neuroimaging techniques show promise as a biomarker for mild traumatic brain injury (mTBI). However, little research has evaluated cerebral hemodynamics or its relation to white matter microstructure post-mTBI in children. This novel pilot study examined differences hemodynamics, measured using functional near-infrared spectroscopy (fNIRS), and association with diffusion tensor imaging (DTI) metrics children mTBI orthopedic (OI) address these gaps. Children 8.00-16.99 years of age...
Background We recently developed a novel machine learning‐based algorithm using multiphase computed tomography angiography (mCTA) to generate perfusion maps of the brain, similar (CTP) (ie, CTA [mCTAp]). Here, we aim validate clinical utility mCTAp in detection brain ischemia and its side, extent, location. Methods In this prospective multi‐reader‐multi‐case analysis, included baseline images: ( StrokeSENS ‐algorithm) CTP (4D; GE Healthcare) from 121 randomly selected patients whose scans...
<h3>Objective</h3> Emerging evidence suggests that advanced neuroimaging of cerebral hemodynamics may yield a clinical biomarker mild traumatic brain injury (mTBI). We examined whether (coherence) and novel (absolute phase) functional near-infrared spectroscopy metrics differentiated children with mTBI from orthopedic (OI). <h3>Design</h3> Prospective cohort <h3>Participants</h3> Children between 8.00–16.99 years age were recruited during emergency department visits at Alberta Children's...
Purpose: To validate the performance of a 3D convolutional neural network (CNN) based algorithm i.e. Stroke SENS LVO, in automatically detecting presence large vessel occlusions (LVO) on computed tomography angiography (CTA) images head. Method: A total 400 studies (217 183 non-LVO) were used analysis. The LVO group includes internal carotid artery (ICA) and m1 segment middle cerebral (M1-MCA) occlusions; non-LVO more distal or posterior occlusions, no hemorrhagic stroke cases. Expert...
Background: In acute ischemic stroke (AIS), Computed Tomography Perfusion (CT, CTP) is the most widely used technique for determining extent of tissue likely to die even after successful reperfusion. However, CTP results in higher radiation dose patient, affected by motion, and not available. Multiphase CT Angiography (mCTA), contrast, a low extension ubiquitous workflow. Here, we evaluate StrokeSENS mCTA Perfusion, software tool that uses estimate brain perfusion, compare it its ability...
<h3>Introduction</h3> A recently developed multiphase-computed-tomography-angiography(mCTA) tool generates perfusion maps, similar to CT-perfusion(CTP) (i.e., mCTA-perfusion[mCTAp]). <h3>Aim of Study</h3> To validate the clinical utility mCTAp. <h3>Methods</h3> In this multi-reader-multi-case analysis, we included baseline images: mCTAp(<i>StrokeSENS</i>-algorithm) and CTP(4D; GE-Healthcare) from 121 randomly selected patients whose scans were not part algorithm-development. After excluding...
Introduction: We recently published a Machine Learning-based algorithm using mCTA (mCTAp) that generates perfusion maps of the brain, similar to CTP. Here, we aim validate clinical utility mCTAp in detection ischemia, it’s side, extent and location. Methods: One hundred twenty-one subjects were included test dataset. These had completed (StrokeSENS) CTP (4D; GE Healthcare) at baseline. After excluding 2/121 due poor image quality, multi-reader-multi-case (n=119) study design was conducted...