A5042581015- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Peripheral Artery Disease Management
- Advanced X-ray and CT Imaging
- Brain Tumor Detection and Classification
- Vascular Malformations Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Meningioma and schwannoma management
- Photoacoustic and Ultrasonic Imaging
- Intracerebral and Subarachnoid Hemorrhage Research
- MRI in cancer diagnosis
- Neurosurgical Procedures and Complications
- Cerebral Venous Sinus Thrombosis
- Pituitary Gland Disorders and Treatments
- Neurological Disorders and Treatments
- Coronary Interventions and Diagnostics
- MicroRNA in disease regulation
- Nanoparticle-Based Drug Delivery
- Clinical Reasoning and Diagnostic Skills
University Hospital of Bern
2024-2025
Masaryk University
2015-2024
St. Anne's University Hospital Brno
2015-2024
University Medical Center Freiburg
2024
University Hospital Brno
2015-2024
University of Calgary
2015-2024
University of Bern
2024
Foothills Medical Centre
2020-2024
Allen Institute for Brain Science
2023
University of Hradec Králové
2020-2022
Distal embolization (DE) is a common complication of endovascular treatment (EVT). We investigated the association radiological thrombus characteristics and details with DE. Patients thin-slice (≤2.5 mm) baseline noncontrast computed tomography angiography from ESCAPE-NA1 trial (Efficacy Safety Nerinetide for Treatment Acute Ischemic Stroke) were included. Thrombus annotation was performed manually on coregistered scans by experienced readers. assessed location, distance internal carotid...
The aim of the present European Stroke Organisation (ESO) guideline is to provide evidence-based recommendations on acute management patients with basilar artery occlusion (BAO). These guidelines were prepared following Standard Operational Procedure ESO and according GRADE methodology. Although BAO accounts for only 1%-2% all strokes, it has very poor natural outcome. We identified 10 relevant clinical situations formulated corresponding Population Intervention Comparator Outcomes (PICO)...
To undertake an effectiveness and safety analysis of EVT in patients with LVO NIH Stroke Scale (NIHSS) score ≤6 using datasets multicenter multinational nature.We pooled anterior circulation occlusion from 3 prospective international cohorts. Patients were eligible if presentation occurred within 12 hours last known well baseline NIHSS ≤6. Primary outcome was modified Rankin (mRS) 0-1 at 90 days. Secondary outcomes included neurologic deterioration 24 (change ≥2 points), mRS 0-2 days, 90-day...
Background The effect of infarct pattern on functional outcome in acute ischemic stroke is incompletely understood. Purpose To investigate the association qualitative and quantitative variables at 24-hour follow-up noncontrast CT diffusion-weighted MRI with 90-day clinical outcome. Materials Methods Safety Efficacy Nerinetide Subjects Undergoing Endovascular Thrombectomy for Stroke, or ESCAPE-NA1, randomized controlled trial enrolled patients large-vessel-occlusion undergoing mechanical...
Background Cerebrospinal fluid (CSF) loss in spontaneous intracranial hypotension (SIH) is accompanied by volume shifts between the compartments. This study investigated tricompartimental and longitudinal after closure of a CSF leak. Methods Patients with SIH suitable pre-therapeutic post-therapeutic imaging for volumetric analysis were identified from our tertiary care center 2020 2023. The Bern score was calculated. Pre-interventional post-interventional volumetry encompassed CSF,...
Introduction: Despite improvements in device technology, only one-third of stroke patients undergoing endovascular thrombectomy (EVT) achieve first-pass effect (FPE). We investigated the arterial tortuosity and thrombus characteristics on relationship between first-line EVT strategy angiographic outcomes. Patients methods: with thin-slice baseline CT-angiography from ESCAPE-NA1 trial (Efficacy safety nerinetide for treatment acute ischemic stroke) were included. Tortuosity was estimated...
Background: Infarct in a new territory (INT) is known complication of endovascular stroke therapy. We assessed the incidence INT, outcomes after and impact concurrent treatments with intravenous thrombolysis nerinetide. Methods: Data are from ESCAPE-NA1 trial (Safety Efficacy Nerinetide [NA-1] Subjects Undergoing Endovascular Thrombectomy for Stroke), multicenter, international randomized study that efficacy nerinetide subjects acute ischemic who underwent thrombectomy within 12 hours onset....
Background Indications for flow diversion stent (FDS) treatment are expanding. However, there is still a lack of evidence the long-term outcome in distally located aneurysms M2 segment middle cerebral artery (MCA) and beyond. Methods Consecutive subjects (from June 2013 to August 2020) with MCA or beyond treated FDS were reviewed retrospectively. The primary endpoints clinical safety absence mortality, stroke event, re-rupture aneurysm, worsening symptoms. endpoint efficacy was...
Background and Purpose: The prognosis of medium vessel occlusions (MeVOs), that is, M2/3 middle cerebral artery, A2/3 anterior P2/3 posterior artery occlusions, is generally better compared with large since brain ischemia less extensive. However, in some MeVO patients, infarcts are seen outside the territory occluded (MeVO discrepant infarcts). This study aims to determine prevalence clinical impact infarct patterns acute ischemic stroke due MeVO. Methods: We pooled data patients from...
We aimed to explore the preference of stroke physicians treat patients with primary medium vessel occlusion (MeVO) immediate endovascular treatment (EVT) in an international cross-sectional survey, as there is no clear guideline recommendation for EVT these patients.In survey MeVO-Finding Rationales and Objectifying New Targets IntervEntional Revascularization Stroke (MeVO-FRONTIERS), participants were shown four cases MeVOs (six scenarios per case) asked whether they would those EVT....
Background The optimal treatment and prognosis for stroke patients with tandem cervical carotid occlusion are unclear. We analyzed outcomes strategies of in the ESCAPE-NA1 trial. Methods was a multicenter international randomized trial nerinetide versus placebo 1105 acute ischemic who underwent endovascular treatment. defined occlusions as complete internal artery (ICA) on catheter angiography, addition to proximal ipsilateral intracranial large vessel occlusion. Baseline characteristics...
<h3>BACKGROUND AND PURPOSE:</h3> Identifying the presence and extent of intracranial thrombi is crucial in selecting patients with acute ischemic stroke for treatment. This article aims to develop an automated approach quantify thrombus on NCCT CTA stroke. <h3>MATERIALS METHODS:</h3> A total 499 large-vessel occlusion from Safety Efficacy Nerinetide Subjects Undergoing Endovascular Thrombectomy Stroke (ESCAPE-NA1) trial were included. All had thin-section images. Thrombi contoured manually...
The aim of the present European Stroke Organisation (ESO) guideline is to provide evidence-based recommendations on acute management patients with basilar artery occlusion (BAO). These guidelines were prepared following Standard Operational Procedure ESO and according GRADE methodology. Although BAO accounts for only 1–2% all strokes, it has very poor natural outcome. We identified 10 relevant clinical situations formulated corresponding Population Intervention Comparator Outcomes (PICO)...
Background We evaluated the association of reperfusion quality and different patterns achieved with clinical radiological outcomes in ESCAPE NA1 trial. Methods Data are from ESCAPE-NA1 Good outcome [90-day modified Rankin Scale (mRS) 0–2], excellent (90-day mRS0–1), isolated subarachnoid hemorrhage, symptomatic hemorrhage (sICH) on follow-up imaging, death were compared across levels defined by expanded Treatment Cerebral Infarction (eTICI) Scale. Comparisons also made between patients (a)...