A5009472773- Neurosurgical Procedures and Complications
- Cerebrospinal fluid and hydrocephalus
- Head and Neck Surgical Oncology
- Spinal Hematomas and Complications
- Cervical and Thoracic Myelopathy
- Spine and Intervertebral Disc Pathology
- Spinal Dysraphism and Malformations
- Spinal Fractures and Fixation Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Medical Imaging and Analysis
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Musculoskeletal pain and rehabilitation
- Aortic Disease and Treatment Approaches
- Glioma Diagnosis and Treatment
- Retinal Imaging and Analysis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cerebral Venous Sinus Thrombosis
- Hemostasis and retained surgical items
- Transcranial Magnetic Stimulation Studies
- Effects of Vibration on Health
- Spinal Cord Injury Research
University of Freiburg
2018-2025
University Medical Center Freiburg
2022-2025
University Hospital Regensburg
2025
Universitätsklinik Balgrist
2013-2018
Knappschaftsklinikum Saar
2016-2017
Berufsgenossenschaftliche Unfallklinik Murnau
2014
University of Zurich
2013
In patients with chronic spinal cord injury, imaging of the and brain above level lesion provides evidence neural degeneration; however, spatial temporal patterns progression their relation to clinical outcomes are uncertain. New interventions targeting acute injury have entered trials but neuroimaging as responsive markers treatment yet be established. We aimed use MRI assess neuronal degeneration after injury.In our prospective longitudinal study, we enrolled traumatic healthy controls....
Type 2 spinal cerebrospinal fluid leaks in patients with spontaneous intracranial hypotension occur after lateral dural tears through which the arachnoid herniates, is visible on MRI scans (ie, “bud-on-branch” sign).
Abstract Background Spinal cord stimulation ( SCS ) is a standard treatment option for chronic neuropathic pain. However, some anatomical pain distributions are known to be difficult cover with traditional ‐induced paresthesias and/or may also induce additional, unwanted stimulation. We present the results from retrospective review of data patients groin various etiologies treated using neuromodulation dorsal root ganglion DRG ). Methods Data 29 were reviewed. Patients underwent trial...
Spontaneous intracranial hypotension (SIH) caused by a spinal CSF leak is multisymptom syndrome, which can dramatically affect physical and mental health. However, systematic data on health-related quality of life (HRQoL) health are scarce. We hypothesized that surgical treatment leads to significant sustained improvements in HRQoL patients with SIH.
The differentiating points between focal nodular hyperplasia (FNH) and malignant hypervascular liver lesions were studied at dynamic gadolinium-enhanced magnetic resonance (MR) imaging. Thirty-six patients with 50 (28 FNH, 12 hepatocellular carcinoma, nine metastases, one cholangiocarcinoma) underwent unenhanced spin-echo (SE) T1- T2-weighted imaging T1-weighted gradient-recalled-echo before repeatedly for 10 minutes after intravenous bolus injection of gadopentetate dimeglumine. On SE...
Abstract Background & purpose Around 5% of dementia patients have a treatable cause. To estimate the prevalence two rare diseases, in which cause is at spinal level. Methods A radiology information system was searched using terms CT myelography and operation classification (OPS) code 3-241. The clinical charts these were reviewed to identify with significant cognitive decline. Results Among 205 spontaneous intracranial hypotension (SIH) proven CSF leaks we identified five so-called...
Cerebrospinal fluid (CSF)-venous fistulas (CVFs) are increasingly identified as a cause of spontaneous intracranial hypotension (SIH). Lateral decubitus digital subtraction myelography (LD-DSM) and CT (LD-CTM) mainly used for detection, but the most sensitive method is yet unknown.
Abstract Design Prospective diagnostic study. Objectives Anatomical evaluation and graduation of the severity spinal stenosis is essential in degenerative cervical spine disease. In clinical practice, this subjectively categorized on MRI lacking an objective reliable classification. We implemented a fully-automated quantification canal compromise through 3D T2-weighted segmentation. Setting Medical Center - University Freiburg, Germany. Methods Evaluation 202 participants receiving spine....
Background Cerebrospinal fluid (CSF) loss in spontaneous intracranial hypotension (SIH) is accompanied by volume shifts between the compartments. This study investigated tricompartimental and longitudinal after closure of a CSF leak. Methods Patients with SIH suitable pre-therapeutic post-therapeutic imaging for volumetric analysis were identified from our tertiary care center 2020 2023. The Bern score was calculated. Pre-interventional post-interventional volumetry encompassed CSF,...
Type 2 CSF leaks are spinal lateral dural tears, causing spontaneous intracranial hypotension (SIH). They may be visualized with digital subtraction myelography (DSM), cone-beam CT (CBCT) myelography, energy-integrating detector or photon-counting myelography. A recently introduced ultrahigh-resolution (UHR-CBCT) has shown beneficial visualization of CSF-venous fistula, another cause SIH. However, the use this technique not yet been reported in imaging type leaks. In technical report, we...
Abstract Background and Importance: Post-dural puncture headache (PDPH) is a well-recognized frequently encountered complaint of Lumbar puncture. It usually resolves spontaneously over two weeks or with an epidural blood patch. Although known for long time, PPDH could be linked to arachnoidal bleb as cause cerebrospinal fluid (CSF) leakage. We report on surgical findings impressive low-flow CSF leakage in the context bleb. Clinical presentation: 42-year-old Neuroscientist 23-month history...
Analysis of B-waves in overnight intracranial pressure (ICP) recordings used to be an important element the diagnosis normal hydrocephalus (NPH). Here, we tested hypothesis that equivalents can detected and quantified a noninvasively measured electric capacitance signal termed W. We ICP W cohort 15 patients with suspected NPH or spontaneous hypotension during infusion testing, identifying both signals by wave-template matching time domain. found very strong correlation between duration (R2 =...
Spinal cerebrospinal fluid (CSF) leaks may cause a myriad of symptoms, most common being orthostatic headache. In addition, ventral spinal CSF are possible etiology superficial siderosis (SS), rare condition characterized by hemosiderin deposits in the central nervous system (CNS). The classical presentation SS involves ataxia, bilateral hearing loss, and myelopathy. Unfortunately, treatment options scarce. This study was undertaken to evaluate whether microsurgical closure can prevent...
Spontaneous intracranial hypotension (SIH) is characterized by loss of CSF volume. We hypothesize that in this situation low volume, a larger flow and spinal cord motion at the upper spine can be measured noninvasive phase contrast MRI.A prospective, age-, sex-, body mass index (BMI)-matched controlled cohort study on patients with SIH presenting longitudinal extradural fluid collection (SLEC) was conducted from October 2021 to February 2022. Cardiac-gated 2D MRI sequences were acquired...
Spontaneous intracranial hypotension due to a spinal cerebrospinal fluid leak causes orthostatic headaches and impacts quality of life. Successful closure rates are often reported, whereas data on long-term outcome still scarce.Between April 2020 December 2022 surgically treated patients completed the Headache Impact Test-6 prior surgery at 14 days, three months, six 12 months postoperatively. In addition score, we extracted related symptoms.Eighty were included. Median score preoperatively...
Abstract Pulsatile spinal cord and CSF velocities related to the cardiac cycle can be depicted by phase‐contrast MRI. Among patients with spontaneous intracranial hypotension, we have recently described relevant differences compared healthy controls in segment C2/C3. The method might a promising tool solve clinical diagnostic ambiguities. Therefore, it is important understand physiological range effects of anatomical parameters volunteers. Within prospective study, 3D T 2 ‐weighted MRI for...
Microsurgical sealing of spinal cerebrospinal fluid (CSF) leaks is a viable treatment option in spontaneous intracranial hypotension (SIH). Several factors may influence the outcome, with symptom duration probably most modifiable variable.
In degenerative cervical myelopathy (DCM), focally increased spinal cord motion has been observed for C5/C6, but whether stenoses at other segments lead to similar pathodynamics and how severity of stenosis, age, gender affect them is still unclear. We report a prospective matched-pair controlled trial on 65 DCM patients. A high-resolution 3D T2 sampling perfection with application-optimized contrasts using different flip angle evolution (SPACE) phase-contrast magnetic resonance imaging...
The underlying pathogenesis of neurological sequelae in post-COVID-19 patients remains unclear. Here, we used multidimensional spatial immune phenotyping and machine learning methods on brains from initial COVID-19 survivors to identify the biological correlate associated with previous SARS-CoV-2 challenge. Compared healthy controls, individuals revealed a high percentage TMEM119
Increased spinal cord motion has been proven to be a relevant finding within canal stenosis disclosed by phase-contrast MRI (PC-MRI). Adapted PC-MRI is suitable and reliable method the well deliberated setting. As decision between conservative operative treatment can challenging in some cases, further diagnostic marker would facilitate process. We hypothesize that increased will correlate clinical course functional impairment contribute as new marker.A monocentric, prospective longitudinal...
Focally increased spinal cord motion at the level of cervical stenosis has been revealed by phase-contrast MRI (PC-MRI). To investigate among patients suffering degenerative myelopathy (DCM) across entire spine applying automated segmentation and standardized PC-MRI post-processing protocols. Prospective, matched-pair controlled trial on 29 with C5/C6. MRI-protocol covering all segments: 3D T2-SPACE, prospectively ECG-triggered sagittal PC-MRI. Segmentation trained hierarchical deep...