A5018482521- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Intracranial Aneurysms: Treatment and Complications
- Heart Rate Variability and Autonomic Control
- Neurological Disorders and Treatments
- Cardiovascular Health and Disease Prevention
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Peripheral Artery Disease Management
- Autoimmune Neurological Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Advanced Chemical Sensor Technologies
- Muscle and Compartmental Disorders
- Eicosanoids and Hypertension Pharmacology
- Advanced Drug Delivery Systems
- Maternal and fetal healthcare
- Genetics and Neurodevelopmental Disorders
- Peripheral Neuropathies and Disorders
- Hospital Admissions and Outcomes
- Pharmaceutical industry and healthcare
- Amyotrophic Lateral Sclerosis Research
- Lipoproteins and Cardiovascular Health
Ljubljana University Medical Centre
2004-2021
Medical University of Warsaw
2012-2015
Institute of Psychiatry and Neurology
2012-2015
University General Hospital Attikon
2015
National and Kapodistrian University of Athens
2015
University Hospital Brno
2015
Masaryk University
2015
University of Debrecen
2014
Universitat de Barcelona
2010
Hospital Universitario Virgen del Rocío
2010
Antibodies to the glutamate receptor 1 (GluR1) and GluR2 subunits of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) (AMPAR-ab) were recently described in 10 patients from a series 109 with limbic encephalitis (LE).1 Besides hippocampus, GluR1/2 AMPAR are also widely expressed cerebral cortex, basal ganglia, cerebellum,2 suggesting that clinical presentation could extend beyond profile LE. In this study, we analyzed presence AMPAR-ab consecutive whose serum or CSF was sent our...
Shortening door-to-needle time (DNT) for the thrombolytic treatment of stroke can improve efficacy by reducing onset-to-treatment time. The goal our study was to explore association between DNT and outcome identify factors influencing better understand why some patients are treated late.Prospectively collected data from Safe Implementation Treatments in Stroke-East registry (SITS-EAST: 9 central eastern European countries) on all with thrombolysis February 2003 2010 were analyzed. Multiple...
Purpose Beyond intravenous thrombolysis, evidence is lacking on acute treatment of minor stroke caused by large artery occlusion. To identify candidates for additional endovascular therapy, we aimed to determine the frequency non-haemorrhagic early neurological deterioration in patients with thrombolysis-treated occlusion proximal and distal cerebral arteries. Secondary aims were establish risk factors report three-month outcomes without deterioration. Method We analysed data from SITS...
Little is known about the effect of thrombolysis in patients with preexisting disability. Our aim was to evaluate impact different levels prestroke disability on patients' profile and outcome after intravenous thrombolysis.We analyzed data all stroke admitted between October 2003 December 2011 that were contributed Safe Implementation Treatments Stroke-Eastern Europe (SITS-EAST) registry. Patients no at (modified Rankin Scale [mRS] score, 0) used as a reference multivariable logistic...
A recent meta-analysis investigating the association between statins and early outcomes in acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) indicated that prestroke statin treatment was associated increased risk of 90-day mortality symptomatic intracranial hemorrhage. We investigated potential pretreatment a large, international registry AIS IVT.We analyzed prospectively collected data from Safe Implementation Treatments Stroke-East (SITS-EAST) on consecutive...
According to the European license, alteplase can be given no sooner than 3 months after previous stroke. However, it is not known whether past history of stroke influences effect treatment. Our aim was evaluate safety and functional outcome intravenous thrombolysis administered in everyday practice patients with stroke≤3 compared those first-ever stroke.We analyzed consecutive cases treated between October 2003 July 2014 contributed Safe Implementation Thrombolysis for Stroke-Eastern Europe...
The insular cortex has been shown experimentally to contain an arrhythmogenic center that may play important role in the genesis of cardiac arrhythmias and electrocardiographic changes patients with intracranial (eg, cerebrovascular) lesions. description our case is intended substantiate this claim a clinical observation. A 37-year-old woman subarachnoid hemorrhage suffered severe reversible arrhythmia after neurosurgical clipping arterial aneurysm removal intracerebral hematoma from region...
While electrocardiographic abnormalities in subarachnoid hemorrhage patients have been known since 1947, the provocative mechanism has not yet satisfactorily explained. The purpose of this study was to evaluate with some tests, role autonomic nervous system provoking 22 hemorrhage. standard tracings and one-channel computer-based for spectral analysis heart rate variability were made. Blood samples plasma norepinephrine concentrations taken. Statistically significant parasympathetic...
In this report, we evaluate the success of immunoadsorption and plasma membrane exchange treatment in patients with severe Guillain-Barré syndrome (GBS), describe one case successfully treated by after failure therapy. Nineteen severely paralyzed GBS patients, aged 14-76 years, who were between 1998 2008, retrospectively studied. They underwent 161 119 procedures. GBS, 4-30 5-31 sessions needed. Among 16 on mechanical ventilation, 11 recovered from disability completely, while patient mild...
Background and purpose Recent cross‐sectional study data suggest that intravenous thrombolysis ( IVT ) in patients with in‐hospital stroke IHS onset is associated unfavorable functional outcomes at hospital discharge mortality compared to out‐of‐hospital OHS treated . We sought compare between ‐treated by analysing propensity‐score‐matched from the Safe Implementation of Treatments Stroke‐East registry. Methods following for all patients: (i) symptomatic intracranial hemorrhage defined safe...
Background and purpose The outcome of thrombolysis for early morning sleep time strokes may be worse because uncertainty stroke onset or differences in logistics. aim the study was to analyze if after intravenous differs depending on day when occurs. Methods data collected Safe Implementation Treatments Stroke − Eastern Europe ( SITS ‐ EAST ) Registry between September 2000 December 2011 were used. Strokes categorized as night‐time 00:00–07:59, day‐time 08:00–15:59 evening‐time 16:00–23:59...
Stroke is a major medical problem and one of the leading causes mortality disability all over in Europe. However, there are significant East–West differences stroke care as well morbidity rates. Central Eastern European countries that formerly had centralized socialist health systems have serious similar problems organizing 20 years after political transition. In Europe, more frequent, rate higher, victims younger than Western High-risk patients live worse environmental conditions,...
CyberKnife offers CT- and MRI-based treatment planning without the need for stereotactically acquired DSA. The literature on of cerebral AVMs is sparse. Here, a large series focusing treated by frameless stereotactic radiosurgery (SRS) system was analyzed.In this retrospective study, patients with SRS between 2005 2019 were included. Planning MRI- CT-based. Conventional DSA not coregistered to MRI CT scans used only as an adjunct. Obliteration dynamics clinical outcome analyzed.215 53.0%...
Objectives. Arterial baroreflex plays a key role in short-term blood pressure balancing. It can also be quantified noninvasively with baroreceptor sensitivity during Valsalva manoeuver. The aim of the study was to evaluate manoeuver as potential marker possible autonomic dysfunction patients after carotid artery angioplasty and stenting.Materials methods. We evaluated dynamic changes (Valsalva ratio, adrenergic sensitivity) 22 (11 male; 63.2 ± 6.7 years) symptomatic, unilateral internal...