A5081907699- Acute Ischemic Stroke Management
- Long-Term Effects of COVID-19
- Advanced Neuroimaging Techniques and Applications
- Atrial Fibrillation Management and Outcomes
- Advanced MRI Techniques and Applications
- COVID-19 and healthcare impacts
- Hormonal Regulation and Hypertension
- Pharmacogenetics and Drug Metabolism
- MRI in cancer diagnosis
- Computational Drug Discovery Methods
- Protease and Inhibitor Mechanisms
- Neurological and metabolic disorders
- Nuclear Receptors and Signaling
- Epilepsy research and treatment
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Syncope and Autonomic Disorders
- Cellular transport and secretion
- Blood Coagulation and Thrombosis Mechanisms
- Pharmacological Effects and Toxicity Studies
- Cerebral Venous Sinus Thrombosis
- Lysosomal Storage Disorders Research
- Trypanosoma species research and implications
- Protein Hydrolysis and Bioactive Peptides
- Functional Brain Connectivity Studies
- Coronary Interventions and Diagnostics
University Hospital in Motol
2020-2025
Charles University
2018-2024
Hospital de Egas Moniz
2022
University of Thessaly
2022
Boston University
2022
Boston Medical Center
2022
Background and aims Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by disease-associated variants in the alpha-galactosidase A gene ( GLA ). FD known cause of stroke younger patients. There are limited data on prevalence risk unselected Methods prospective nationwide study including 35 (78%) all 45 centers consecutive patients admitted during three months. Clinical were collected RES-Q database. was diagnosed using dried blood spots stepwise manner: males—enzymatic...
Disruption of the blood-brain barrier (BBB) is a key feature various brain disorders. To assess its integrity parametrization dynamic magnetic resonance imaging (DCE MRI) with contrast agent (CA) broadly used. Parametrization can be done quantitatively or semi-quantitatively. Quantitative methods directly describe BBB permeability but exhibit several drawbacks such as high computation demands, reproducibility issues, low robustness. Semi-quantitative are fast to compute, simply...
This study aimed to evaluate the ability of selected microRNAs as biomarkers atrial fibrillation (AF) in ischemic stroke patients comparison with other established biochemical biomarkers. A prospective case–control consecutive AF admitted a comprehensive center was conducted. The control group consisted no detected on prolonged (at least 3 weeks) Holter ECG monitoring. As potential AF, we analyzed plasma levels (miR-21, miR-29b, miR-133b, miR-142-5p, miR-150, miR-499, and miR-223-3p) 13 at...
Introduction: Dabigatran is direct thrombin inhibitor approved in the prevention of stroke patients with atrial fibrillation. It was shown RELY trial substudy that genetic variants could contribute to interindividual variability concentrations active metabolite dabigatran and influence safety treatment. Carriage CES1 rs2244613 minor allele associated lower exposure a bleeding risk compared wild-type allele. Aim: To determine gene polymorphism through plasmatic concentration on occurrence...
Embolický iktus z neurčeného zdroje (embolic stroke of undetermined source, ESUS) je nově vymezenou podskupinou kryptogenní cévní mozkové příhody.ESUS definován jako nelakunární mozková ischemie bez proximální arteriální stenózy a významného kardioembolizace indikovaného k antikoagulační léčbě.Optimální léčba ke snížení rizika recidivy podle současných doporučených postupů antiagregační léčba.Riziko po ESUS vysoké, proto zkoušena alternativně novými přímými antikoagulancii (DOAC).Tento...
Abstract Objectives Warfarin use is limited by a low therapeutic index and significant interindividual variability of the daily dose. The most important factor predicting warfarin dose individual genotype, polymorphisms genes CYP2C9 (warfarin metabolism) VKORC1 (sensitivity for warfarin). Algorithms using clinical genetic variables could predict before initiation therapy. aim this study was to develop validate an algorithm prediction in Czech patients. Methods Detailed data patients with...
Despite the rising global burden of stroke and its socio-economic implications, neuroimaging predictors subsequent cognitive impairment are still poorly understood. We address this issue by studying relationship white matter integrity assessed within ten days after patients’ status one year attack. Using diffusion-weighted imaging, we apply Tract-Based Spatial Statistics analysis construct individual structural connectivity matrices employing deterministic tractography. further quantify...
Abstract Objectives Warfarin use is limited by a low therapeutic index and significant interindividual variability of the daily dose. The most important factor predicting warfarin dose individual genotype, polymorphisms genes CYP2C9 (warfarin metabolism) VKORC1 (sensitivity for warfarin). Algorithms using clinical genetic variables could predict before initiation therapy. aim this study was to develop validate an algorithm prediction in Czech patients. Methods Detailed data patients with...